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Grade III glioma

MedGen UID:
925529
•Concept ID:
C4287997
•
Neoplastic Process
Synonyms: Anaplastic Glioma; anaplastic glioma; grade III glioma; WHO Grade 3 Glioma; WHO Grade III Glioma; WHO grade III glioma
 
Monarch Initiative: MONDO:0021640

Definition

A group of malignant gliomas that includes anaplastic astrocytoma, anaplastic oligodendroglioma, anaplastic oligoastrocytoma, and anaplastic ependymoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade III glioma

Professional guidelines

PubMed

Tumor Volume Changes During and After Temozolomide Treatment for Newly Diagnosed Higher-Grade Glioma (III and IV).
Wang HC, Lin YT, Lin WC, Ho RW, Lin YJ, Tsai NW, Ho JT, Lu CH
World Neurosurg 2018 Jun;114:e766-e774. Epub 2018 Mar 16 doi: 10.1016/j.wneu.2018.03.078. PMID: 29555610
Input of molecular analysis in medical management of primary brain tumor patients.
Idbaih A, Duran-Peña A, Bonnet C, Ducray F
Rev Neurol (Paris) 2015 Jun-Jul;171(6-7):457-65. Epub 2015 May 27 doi: 10.1016/j.neurol.2015.04.002. PMID: 26026669
Single-agent bevacizumab is an effective treatment in recurrent glioblastoma.
Hacibekiroglu I, Kodaz H, Erdogan B, Turkmen E, Ozcelik M, Esenkaya A, Saygi HM, Uzunoglu S, Cicin I
Med Oncol 2015 Feb;32(2):460. Epub 2015 Jan 9 doi: 10.1007/s12032-014-0460-3. PMID: 25572814

Recent clinical studies

Etiology

Demystifying neuroblastoma malignancy through fractal dimension, entropy, and lacunarity.
Donato I, Velpula KK, Tsung AJ, Tuszynski JA, Sergi CM
Tumori 2023 Aug;109(4):370-378. Epub 2023 Jan 16 doi: 10.1177/03008916221146208. PMID: 36645143
Concurrent and Adjuvant Temozolomide for Newly Diagnosed Grade III Gliomas without 1p/19q Co-deletion: A Randomized, Open-Label, Phase 2 Study (KNOG-1101 Study).
Hwang K, Kim TM, Park CK, Chang JH, Jung TY, Kim JH, Nam DH, Kim SH, Yoo H, Hong YK, Kim EY, Lee DE, Joo J, Kim YJ, Choe G, Choi BS, Kang SG, Kim JH, Kim CY
Cancer Res Treat 2020 Apr;52(2):505-515. Epub 2019 Oct 28 doi: 10.4143/crt.2019.421. PMID: 31671938Free PMC Article
Input of molecular analysis in medical management of primary brain tumor patients.
Idbaih A, Duran-Peña A, Bonnet C, Ducray F
Rev Neurol (Paris) 2015 Jun-Jul;171(6-7):457-65. Epub 2015 May 27 doi: 10.1016/j.neurol.2015.04.002. PMID: 26026669
Chemotherapy in glioma.
Taal W, Bromberg JE, van den Bent MJ
CNS Oncol 2015;4(3):179-92. Epub 2015 Apr 23 doi: 10.2217/cns.15.2. PMID: 25906059Free PMC Article
Temozolomide during and after radiation therapy for WHO grade III gliomas: preliminary report of a prospective multicenter study.
Kim YH, Park CK, Cho WH, Kim IA, Moon S, Choe G, Park SH, Kim IH, Kim DG, Jung HW, Lee MM, Bae SH, Cha SH, Kim CY
J Neurooncol 2011 Jul;103(3):503-12. Epub 2010 Sep 24 doi: 10.1007/s11060-010-0404-5. PMID: 20862518

Diagnosis

Demystifying neuroblastoma malignancy through fractal dimension, entropy, and lacunarity.
Donato I, Velpula KK, Tsung AJ, Tuszynski JA, Sergi CM
Tumori 2023 Aug;109(4):370-378. Epub 2023 Jan 16 doi: 10.1177/03008916221146208. PMID: 36645143
Biomarkers in Recurrent Grade III Glioma Patients Treated with Bevacizumab and Irinotecan.
Toft A, Urup T, Christensen IJ, Michaelsen SR, Lukram B, Grunnet K, Kosteljanetz M, Larsen VA, Lassen U, Broholm H, Poulsen HS
Cancer Invest 2018 Feb 7;36(2):165-174. Epub 2018 Feb 2 doi: 10.1080/07357907.2018.1430818. PMID: 29393706
Anaplastic astrocytoma.
Grimm SA, Chamberlain MC
CNS Oncol 2016 Jul;5(3):145-57. Epub 2016 May 27 doi: 10.2217/cns-2016-0002. PMID: 27230974Free PMC Article
Input of molecular analysis in medical management of primary brain tumor patients.
Idbaih A, Duran-Peña A, Bonnet C, Ducray F
Rev Neurol (Paris) 2015 Jun-Jul;171(6-7):457-65. Epub 2015 May 27 doi: 10.1016/j.neurol.2015.04.002. PMID: 26026669
Chemotherapy in glioma.
Taal W, Bromberg JE, van den Bent MJ
CNS Oncol 2015;4(3):179-92. Epub 2015 Apr 23 doi: 10.2217/cns.15.2. PMID: 25906059Free PMC Article

Therapy

Concurrent and Adjuvant Temozolomide for Newly Diagnosed Grade III Gliomas without 1p/19q Co-deletion: A Randomized, Open-Label, Phase 2 Study (KNOG-1101 Study).
Hwang K, Kim TM, Park CK, Chang JH, Jung TY, Kim JH, Nam DH, Kim SH, Yoo H, Hong YK, Kim EY, Lee DE, Joo J, Kim YJ, Choe G, Choi BS, Kang SG, Kim JH, Kim CY
Cancer Res Treat 2020 Apr;52(2):505-515. Epub 2019 Oct 28 doi: 10.4143/crt.2019.421. PMID: 31671938Free PMC Article
Biomarkers in Recurrent Grade III Glioma Patients Treated with Bevacizumab and Irinotecan.
Toft A, Urup T, Christensen IJ, Michaelsen SR, Lukram B, Grunnet K, Kosteljanetz M, Larsen VA, Lassen U, Broholm H, Poulsen HS
Cancer Invest 2018 Feb 7;36(2):165-174. Epub 2018 Feb 2 doi: 10.1080/07357907.2018.1430818. PMID: 29393706
Anaplastic astrocytoma.
Grimm SA, Chamberlain MC
CNS Oncol 2016 Jul;5(3):145-57. Epub 2016 May 27 doi: 10.2217/cns-2016-0002. PMID: 27230974Free PMC Article
Chemotherapy in glioma.
Taal W, Bromberg JE, van den Bent MJ
CNS Oncol 2015;4(3):179-92. Epub 2015 Apr 23 doi: 10.2217/cns.15.2. PMID: 25906059Free PMC Article
Single-agent bevacizumab is an effective treatment in recurrent glioblastoma.
Hacibekiroglu I, Kodaz H, Erdogan B, Turkmen E, Ozcelik M, Esenkaya A, Saygi HM, Uzunoglu S, Cicin I
Med Oncol 2015 Feb;32(2):460. Epub 2015 Jan 9 doi: 10.1007/s12032-014-0460-3. PMID: 25572814

Prognosis

Demystifying neuroblastoma malignancy through fractal dimension, entropy, and lacunarity.
Donato I, Velpula KK, Tsung AJ, Tuszynski JA, Sergi CM
Tumori 2023 Aug;109(4):370-378. Epub 2023 Jan 16 doi: 10.1177/03008916221146208. PMID: 36645143
Biomarkers in Recurrent Grade III Glioma Patients Treated with Bevacizumab and Irinotecan.
Toft A, Urup T, Christensen IJ, Michaelsen SR, Lukram B, Grunnet K, Kosteljanetz M, Larsen VA, Lassen U, Broholm H, Poulsen HS
Cancer Invest 2018 Feb 7;36(2):165-174. Epub 2018 Feb 2 doi: 10.1080/07357907.2018.1430818. PMID: 29393706
Anaplastic astrocytoma.
Grimm SA, Chamberlain MC
CNS Oncol 2016 Jul;5(3):145-57. Epub 2016 May 27 doi: 10.2217/cns-2016-0002. PMID: 27230974Free PMC Article
Input of molecular analysis in medical management of primary brain tumor patients.
Idbaih A, Duran-Peña A, Bonnet C, Ducray F
Rev Neurol (Paris) 2015 Jun-Jul;171(6-7):457-65. Epub 2015 May 27 doi: 10.1016/j.neurol.2015.04.002. PMID: 26026669
Temozolomide during and after radiation therapy for WHO grade III gliomas: preliminary report of a prospective multicenter study.
Kim YH, Park CK, Cho WH, Kim IA, Moon S, Choe G, Park SH, Kim IH, Kim DG, Jung HW, Lee MM, Bae SH, Cha SH, Kim CY
J Neurooncol 2011 Jul;103(3):503-12. Epub 2010 Sep 24 doi: 10.1007/s11060-010-0404-5. PMID: 20862518

Clinical prediction guides

Demystifying neuroblastoma malignancy through fractal dimension, entropy, and lacunarity.
Donato I, Velpula KK, Tsung AJ, Tuszynski JA, Sergi CM
Tumori 2023 Aug;109(4):370-378. Epub 2023 Jan 16 doi: 10.1177/03008916221146208. PMID: 36645143
Biomarkers in Recurrent Grade III Glioma Patients Treated with Bevacizumab and Irinotecan.
Toft A, Urup T, Christensen IJ, Michaelsen SR, Lukram B, Grunnet K, Kosteljanetz M, Larsen VA, Lassen U, Broholm H, Poulsen HS
Cancer Invest 2018 Feb 7;36(2):165-174. Epub 2018 Feb 2 doi: 10.1080/07357907.2018.1430818. PMID: 29393706
Single-agent bevacizumab is an effective treatment in recurrent glioblastoma.
Hacibekiroglu I, Kodaz H, Erdogan B, Turkmen E, Ozcelik M, Esenkaya A, Saygi HM, Uzunoglu S, Cicin I
Med Oncol 2015 Feb;32(2):460. Epub 2015 Jan 9 doi: 10.1007/s12032-014-0460-3. PMID: 25572814
Survival and prognostic factors of anaplastic gliomas.
Nuño M, Birch K, Mukherjee D, Sarmiento JM, Black KL, Patil CG
Neurosurgery 2013 Sep;73(3):458-65; quiz 465. doi: 10.1227/01.neu.0000431477.02408.5e. PMID: 23719055
Temozolomide during and after radiation therapy for WHO grade III gliomas: preliminary report of a prospective multicenter study.
Kim YH, Park CK, Cho WH, Kim IA, Moon S, Choe G, Park SH, Kim IH, Kim DG, Jung HW, Lee MM, Bae SH, Cha SH, Kim CY
J Neurooncol 2011 Jul;103(3):503-12. Epub 2010 Sep 24 doi: 10.1007/s11060-010-0404-5. PMID: 20862518

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