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LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-.
LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet].
Show detailsOVERVIEW
The term "antirheumatic drugs" refers to agents used in the therapy of inflammatory arthritis, predominantly rheumatoid arthritis, but also idiopathic juvenile arthritis, psoriatic arthritis, ankylosing spondylitis and others. Aspirin, the nonsteroidal antiinflammatory agents and corticosteroids are used commonly in these conditions, but have little effect in altering the natural history and outcomes of inflammatory arthritis, which can lead to cartilage and joint destruction and severe disability. More important and diverse are the "Disease-Modifying Anti-Rheumatic Drugs" (DMARDs) which are the mainstay of therapy in rheumatoid arthritis and have dramatically altered the outcome of these conditions, and improved the quality of life of patients with rheumatoid arthritis.
The initial DMARDs were the gold preparations which were first used in the 1930s. More potent and better tolerated agents followed in the 1950s and 1960s, including methotrexate, hydroxychloroquine, sulfasalazine, penicillamine, azathioprine and the thiopurines. More modern DMARDs have included potent, small molecule immunosuppressive agents such as leflunomide, cyclosporine, tacrolimus and mycophenolate. More recently, monoclonal antibodies and biologics have been developed that act on the primary cytokines and inflammatory pathways that are active and play a major role in rheumatoid arthritis. These important agents include the tumor necrosis factor antagonists, anticytokines (such as anakinra) and other major immunosuppressive agents (rituximab, abatacept, and tocilizumab). Agents used predominantly as antirheumatic drugs are listed below with specific links to the individual drugs. Medications for gout are given under "Antigout Agents" and nonsteroid antiinflammatory agents under "NSAIDs".
- Thiopurines
- Tyrosine (Janus) Kinase Inhibitors
- Miscellaneous
- Review Infection risk in patients undergoing treatment for inflammatory arthritis: non-biologics versus biologics.[Expert Rev Clin Immunol. 2020]Review Infection risk in patients undergoing treatment for inflammatory arthritis: non-biologics versus biologics.Chiu YM, Chen DY. Expert Rev Clin Immunol. 2020 Feb; 16(2):207-228. Epub 2020 Jan 11.
- Review Methotrexate monotherapy and methotrexate combination therapy with traditional and biologic disease modifying anti-rheumatic drugs for rheumatoid arthritis: A network meta-analysis.[Cochrane Database Syst Rev. 2016]Review Methotrexate monotherapy and methotrexate combination therapy with traditional and biologic disease modifying anti-rheumatic drugs for rheumatoid arthritis: A network meta-analysis.Hazlewood GS, Barnabe C, Tomlinson G, Marshall D, Devoe DJ, Bombardier C. Cochrane Database Syst Rev. 2016 Aug 29; 2016(8):CD010227. Epub 2016 Aug 29.
- Review Review of eight pharmacoeconomic studies of the value of biologic DMARDs (adalimumab, etanercept, and infliximab) in the management of rheumatoid arthritis.[J Manag Care Pharm. 2006]Review Review of eight pharmacoeconomic studies of the value of biologic DMARDs (adalimumab, etanercept, and infliximab) in the management of rheumatoid arthritis.Doan QV, Chiou CF, Dubois RW. J Manag Care Pharm. 2006 Sep; 12(7):555-69.
- Review Renal toxicity associated with disease-modifying antirheumatic drugs used for the treatment of rheumatoid arthritis.[Semin Arthritis Rheum. 2000]Review Renal toxicity associated with disease-modifying antirheumatic drugs used for the treatment of rheumatoid arthritis.Schiff MH, Whelton A. Semin Arthritis Rheum. 2000 Dec; 30(3):196-208.
- Review The use of biological agents in the treatment of rheumatoid arthritis.[Ann Acad Med Singap. 2007]Review The use of biological agents in the treatment of rheumatoid arthritis.Fan PT, Leong KH. Ann Acad Med Singap. 2007 Feb; 36(2):128-34.
- Antirheumatic Agents - LiverToxAntirheumatic Agents - LiverTox
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