GEO DataSets

(Submitter supplied) RNAseq data profiling the artemisinin-sensitive P. falciparum piggyBac mutant of the KIC5 gene (PF3D7_1138700, Kelch13 Interacting Candidate 5).

Organism:

Plasmodium falciparum; Plasmodium falciparum NF54

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL23997 GPL21298

20 Samples

Download data: XLSX

(Submitter supplied) We identified wew chromodomain containing protein that binds to H3K9me3 mark in P. falciparum. To identify its global positioning on the genome of P. falciparum, we perfromed ChIP sequencing using inhouse generated anti-PfCDP antibody. The sheared chromatin was prepared from the P. falciparum culture and subjected for ChIP followed by library preparation from the ChIP DNA and were subjected to sequencing using the HiSeqIllumina platform. more...

Organism:

Plasmodium falciparum NF54

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL30427

3 Samples

Download data: XLSX

(Submitter supplied) Clonally variant genes (CVGs) play fundamental roles in the adaptation of Plasmodium falciparum parasites to the fluctuating conditions of the human host, but their expression patterns under the natural conditions of the blood circulation have been characterized in detail only for a few specific gene families. Here we provide a detailed characterization of the full P. falciparum transcriptome across the full intraerythrocytic development cycle (IDC) at the onset of a blood infection in non-immune human volunteers. more...

Organism:

Plasmodium falciparum; Plasmodium falciparum NF54

Type:

Expression profiling by array

Platform:

GPL26985

24 Samples

Download data: TXT, XLSX

(Submitter supplied) The Plasmodium sexual gametocyte stages are the only transmissible form of the malaria parasite and are thus responsible for the continued transmission of the disease. Gametocytes undergo extensive functional and morphological changes from commitment to maturity, directed by an equally extensive control program. Several interconnected mechanisms governing sexual commitment have been described. However, the processes that drive the subsequent differentiation and development of the gametocyte remain largely unexplored. more...

Organism:

Plasmodium falciparum NF54

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL29510

17 Samples

Download data: BIGWIG, TXT

(Submitter supplied) Global transcriptomic profiling of JIB-04 treated and untreated control early gametocytes to determine the downstream effects of Jumonji histone demethylase inhibition on development

Organism:

Plasmodium falciparum; Plasmodium falciparum NF54

Type:

Expression profiling by array

Platform:

GPL15130

4 Samples

Download data: TXT

(Submitter supplied) The objective of this study is to characterize the overall transcriptome of P. falciparum NF54 derived from a controlled-human malaria infection (CHMI) study. Healthy, immunologically naïve human volunteers were infected intradermally or intravenously with different dosages of Plasmodium falciparum sporozoites (Sanaria® PfSPZ Challenge). Parasites were isolated from these volunteers and subjected to a range of in vitro culture generation prior to RNA collection.

Organism:

Plasmodium falciparum; Plasmodium falciparum 3D7; Plasmodium falciparum NF54

Type:

Expression profiling by array

Platform:

GPL18893

55 Samples

Download data: GPR

(Submitter supplied) Malaria parasites go through major transitions during their complex life cycle, yet the underlying differentiation pathways remain obscure. Here we apply single cell transcriptomics to unravel events that initiate sexual development in preparation for transmission of the parasite from human to mosquito. This proof-of-concept study provides a template to capture transcriptional diversity in heterogeneous parasite populations, with major implications for our understanding of parasite biology and the ongoing malaria elimination campaign.

Organism:

Plasmodium falciparum NF54

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23997

1155 Samples

Download data: TSV

(Submitter supplied) Antigenic variation in Plasmodium falciparum is achieved by transcriptional switching amongst polymorphic var genes, enforced by epigenetic modification of chromatin. Histone-modifying ‘sirtuin’ enzymes PfSir2a and PfSir2b have been implicated in this process. We examined the effect of genetic disruption of sirtuins on var gene expression. Comparative Genomic Hybridization profile indicate that loss of PfSir2a in 3D7 resulted in strikingly rearranged chromosomes.

Organism:

Plasmodium falciparum; Plasmodium falciparum 3D7; Plasmodium falciparum NF54

Type:

Genome variation profiling by genome tiling array

Platform:

GPL19254

2 Samples

Download data: PAIR, TXT

(Submitter supplied) Transcriptomic Analysis of Cultured Sporozoites of P. falciparum

Organism:

Plasmodium falciparum NF54

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18008

6 Samples

Download data: TXT