Similar studies for GEO DataSets (Select 200008562) - GEO DataSets

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Items: 20

Select item 2000085621.

XBP1 confers estrogen independence and antiestrogen resistance in breast cancer cell lines

(Submitter supplied) Human X-box binding protein-1 (XBP1) is an alternatively spliced transcription factor that participates in the unfolded protein response (UPR), a stress signaling pathway that allows cells to survive the accumulation of unfolded proteins in the endoplasmic reticulum lumen. We have previously demonstrated that XBP1 expression is increased in antiestrogen-resistant breast cancer cell lines, and is co-expressed with estrogen receptor alpha (ER) in breast tumors. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2861
Platform:: GPL96
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE8562

ID:: 200008562

Select item 28612.

X-Box binding protein overexpression effect on breast cancer cell line

Analysis of MCF7 breast cancer (BC) cells overexpressing spliced X-box binding protein-1 (XBP1), a transcription factor that participates in the unfolded protein response (UPR). Results provide insight into the role of XBP1 and the UPR in estrogen and antiestrogen responsiveness in breast cancer.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 protocol sets

Platform:: GPL96
Series:: GSE8562
6 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS2861

ID:: 2861

Select item 2001016913.

BRCA1-mimetic compound NSC35446.HCl inhits IKKB expression by reducing estrogen receptor alpha occupancy in the IKKB promoter and inhibts NF-κB activity in anti-estrogen resitant human breast cells

(Submitter supplied) We previously identified small molecules that fit into a BRCA1-binding pocket within estrogen receptor-alpha (ER), mimic the ability of BRCA1 to inhibit ER activity (“BRCA1-mimetics”), and overcome antiestrogen resistance. One such compound, the hydrochloride salt of NSC35446 (“NSC35446.HCl”), also inhibited growth of antiestrogen-resistant LCC9 tumor xenografts. The purpose of this study was to investigate the down-stream effects of NSC35446.HCl and its mechanism of action. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
4 Samples

Download data: TXT

Series

Accession:: GSE101691

ID:: 200101691

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000149864.

Antiestrogen-resistant subclones of MCF-7 human breast cancer cells are derived from a common clonal drug-resistant progenitor

(Submitter supplied) Emergence of antiestrogen-resistant cells in MCF-7 cells during suppression of estrogen signaling is a widely accepted model of acquired breast cancer resistance to endocrine therapy. To obtain insight into the genomic basis of endocrine therapy resistance, we characterized MCF-7 monoclonal sublines that survived 21-day exposure to tamoxifen (T-series sublines) or fulvestrant (F-series sublines) and sublines unselected by drugs (U-series). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
30 Samples

Download data: CEL

Series

Accession:: GSE14986

ID:: 200014986

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000073785.

Expression data from age-dichotomized ER+, N0 breast tumors

(Submitter supplied) Signaling pathways that converge on two different transcription factor complexes, NFκB and AP-1, have been identified in estrogen receptor (ER)-positive breast cancers resistant to the antiestrogen, tamoxifen. In this study, biomarkers co-ordinately up-regulated by NFKB and AP-1 with prognositic significance are identified in a largely TAM-treated set of ER+ node negative breast cancers. The prognostic value with respect to age is also investigated. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4685
54 Samples

Download data: CEL

Series

Accession:: GSE7378

ID:: 200007378

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000499556.

Genome-wide maps of XBP1 binding sites in different breast cancer cell lines.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11154 GPL570
19 Samples

Download data: BED, BW, CEL

Series

Accession:: GSE49955

ID:: 200049955

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000499537.

Expression data from two breast cancer cell lines

(Submitter supplied) During cancer progression, carcinoma cells encounter a variety of cytotoxic stresses such as hypoxia, nutrient deprivation, and low pH as a result of inadequate vascularization. To maintain survival and growth in the face of these physiologic stressors, a set of adaptive response pathways are induced. One adaptive pathway well studied in other contexts is the unfolded protein response (UPR), of which XBP1 is an important component. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
8 Samples

Download data: CEL

Series

Accession:: GSE49953

ID:: 200049953

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000499528.

Genome-wide maps of XBP1 binding sites in different breast cancer cell lines [ChIP-Seq]

(Submitter supplied) We report the application of ChIP-seq, which combines chromatin immunoprecipitation (ChIP) with massively parallel DNA sequencing, to map genome-wide XBP1 binding sites in different breast cancer cell lines. We showed that HIF1α motif was enriched in XBP1 binding sites in triple negative breast cancer (TNBC) cell lines, but not enriched in ER positive breast cancer cell line. We also demonstrated that different breast cancer cell lines of the same sub-type had similar XBP1 binding sites, whereas different breast cancer sub-types had majorly different XBP1 binding sites. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
11 Samples

Download data: BED, BW

Series

Accession:: GSE49952

ID:: 200049952

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001453259.

RNA sequencing of ER+ breast tumor treated with letrozole

(Submitter supplied) Transcriptome of ER+ breast tumors treated with letrozole were profiled by RNA-seq

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21290
58 Samples

Download data: CSV

Series

Accession:: GSE145325

ID:: 200145325

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20003795510.

ERa-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL9115 GPL570
14 Samples

Download data: CEL, CHP, TXT

Series

Accession:: GSE37955

ID:: 200037955

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002730011.

Estrogen-independent genomic ER binding analysis

(Submitter supplied) Hormone-independent breast cancer cells (MCF-7/LTED and HCC-1428/LTED) were analyzed by ChIP-seq for estrogen receptor a to identify ER-DNA binding events that occur in the absence of estrogens.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9115
2 Samples

Download data: TXT

Series

Accession:: GSE27300

ID:: 200027300

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20002253312.

Breast cancer cells resistant to hormone deprivation maintain an estrogen receptor alpha-dependent, E2F-directed transcriptional program

(Submitter supplied) A significant fraction of breast cancers exhibit de novo or acquired resistance to estrogen deprivation. To model resistance to aromatase inhibitor (AI) therapy, long-term estrogen-deprived (LTED) derivatives of MCF-7 and HCC-1428 cells were generated through culture for 3 and 7 months under hormone-depleted conditions, respectively. These LTED cells showed sensitivity to the ER downregulator fulvestrant under hormone-depleted conditions, suggesting continued dependence upon ER signaling for hormone-independent growth. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
12 Samples

Download data: CEL, CHP

Series

Accession:: GSE22533

ID:: 200022533

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003121613.

The ets transcription factor ELF5 suppresses the estrogen sensitive phenotype and contributes to antiestrogen resistance in luminal breast cancer. [human ChIP-Seq]

(Submitter supplied) The ets transcription factor ELF5 specifies the differentiation of mammary progenitor cells to establish the milk-secreting lineage. ER- and poor prognosis basal breast cancers arise from this progenitor cell and these cancers express high levels of Elf5. Knockdown of ELF5 expression in basal breast cancer cell lines, or forced expression in luminal breast cancer cell lines, resulted in reduced cell proliferation. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL10999
4 Samples

Download data: BED, WIG

Series

Accession:: GSE31216

ID:: 200031216

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20003040714.

The ets transcription factor ELF5 suppresses the estrogen sensitive phenotype and contributes to antiestrogen resistance in luminal breast cancer.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL10999 GPL6244
18 Samples

Download data: BED, CEL, WIG

Series

Accession:: GSE30407

ID:: 200030407

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003040515.

The ets transcription factor ELF5 suppresses the estrogen sensitive phenotype and contributes to antiestrogen resistance in luminal breast cancer. [human]

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
14 Samples

Download data: CEL

Series

Accession:: GSE30405

ID:: 200030405

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002551916.

Promoter methylation data: OHT/ICI-sensitive vs. -resistant cell lines

(Submitter supplied) MCF7 breast cancer cell lines: drug-resistant (OHT and ICI) cell lines vs. drug-sensitive (wild type) cell lines. Assessment of association between gene expression and methylation.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL14671
2 Samples

Download data: TXT

Series

Accession:: GSE25519

ID:: 200025519

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20015328517.

FGFR1 associates with gene promoters and regulates gene transcription: Implications for endocrine resistance in ER+/FGFR1-amplified breast cancer [CAMA1_ChIP-Seq]

(Submitter supplied) Using ChIP-Seq analysis of ER+/FGFR1-amplified breast cancer cells and PDXs, we found FGFR1 occupancy at transcription start sites with high overlap with histone modifications associated with active gene transcription. Mass spectrometry analysis of the nuclear and chromatin-bound FGFR1 interactome identified RNA-Polymerase II (Pol II) and FOXA1, with FOXA1 silencing impairing FGFR1 recruitment to chromatin. more...