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Optc opticin [ Mus musculus (house mouse) ]

Gene ID: 269120, updated on 6-Jun-2024

Summary

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Official Symbol
Optcprovided by MGI
Official Full Name
opticinprovided by MGI
Primary source
MGI:MGI:2151113
See related
Ensembl:ENSMUSG00000010311 AllianceGenome:MGI:2151113
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Involved in collagen fibril organization. Acts upstream of or within negative regulation of angiogenesis. Located in extracellular matrix. Is expressed in ciliary body; ciliary epithelium; and retina. Orthologous to human OPTC (opticin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 16.2), stomach adult (RPKM 3.6) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Optc in Genome Data Viewer
Location:
1 E4; 1 58.02 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (133824937..133837344, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (133897193..133909688, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41954 Neighboring gene predicted gene 28441 Neighboring gene STARR-seq mESC enhancer starr_02307 Neighboring gene predicted gene, 31515 Neighboring gene proline arginine-rich end leucine-rich repeat Neighboring gene predicted gene 1627

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Analysis of opticin binding to collagen fibrils identifies a single binding site in the gap region and a high specificity towards thin heterotypic fibrils containing collagens II, and XI or V/XI. Hansen U, et al. PLoS One, 2020. PMID 32764753, Free PMC Article
  2. In vivo effect of opticin deficiency in cartilage in a surgically induced mouse model of osteoarthritis. Farrán A, et al. Sci Rep, 2018 Jan 11. PMID 29323130, Free PMC Article
  3. Opticin exerts its anti-angiogenic activity by regulating extracellular matrix adhesiveness. Le Goff MM, et al. J Biol Chem, 2012 Aug 10. PMID 22669977, Free PMC Article
  4. The vitreous glycoprotein opticin inhibits preretinal neovascularization. Le Goff MM, et al. Invest Ophthalmol Vis Sci, 2012 Jan 25. PMID 22159013, Free PMC Article
  5. Protein localization in the human eye and genetic screen of opticin. Friedman JS, et al. Hum Mol Genet, 2002 May 15. PMID 12019215

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Analysis of opticin binding to collagen fibrils identifies a single binding site in the gap region and a high specificity towards thin heterotypic fibrils containing collagens II, and XI or V/XI.
    Title: Analysis of opticin binding to collagen fibrils identifies a single binding site in the gap region and a high specificity towards thin heterotypic fibrils containing collagens II, and XI or V/XI.
  2. opticin binds to collagen and thereby competitively inhibits endothelial cell interactions with collagen via alpha(1)beta(1) and alpha(2)beta(1) integrins, thereby preventing the strong adhesion that is required for proangiogenic signaling via these integrins.
    Title: Opticin exerts its anti-angiogenic activity by regulating extracellular matrix adhesiveness.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC117622

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in articular cartilage development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in bone development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in collagen fibril organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in collagen fibril organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
opticin
Names
oculoglycan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160420.3 → NP_001153892.2  opticin isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC131998, AC157924, FQ976559
    Consensus CDS
    CCDS48366.1
    UniProtKB/TrEMBL
    Q14BF5, Q3U5A9
    Related
    ENSMUSP00000123262.4, ENSMUST00000153617.10

  2. NM_001160421.3 → NP_001153893.2  opticin isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC131998, AC157924, FQ976559
    Consensus CDS
    CCDS48366.1
    UniProtKB/TrEMBL
    Q14BF5, Q3U5A9
    Related
    ENSMUSP00000115661.3, ENSMUST00000149380.9

  3. NM_001160422.2 → NP_001153894.2  opticin isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC131998
    UniProtKB/TrEMBL
    F6Z4X6, Q4KL49
    Related
    ENSMUSP00000117086.3, ENSMUST00000126123.3

  4. NM_001395557.3 → NP_001382486.2  opticin isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC131998
    UniProtKB/TrEMBL
    F6Z4X6, Q4KL49

  5. NM_001395558.3 → NP_001382487.2  opticin isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC131998, AC157924, FQ976559
    UniProtKB/Swiss-Prot
    Q8K3K2, Q91ZZ9, Q920A0
    UniProtKB/TrEMBL
    Q14BF5

  6. NM_001423441.1 → NP_001410370.1  opticin isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC131998, AC157924, FQ976559
    UniProtKB/Swiss-Prot
    Q8K3K2, Q91ZZ9, Q920A0
    UniProtKB/TrEMBL
    Q14BF5

  7. NM_001423442.1 → NP_001410371.1  opticin isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC131998, AC157924, FQ976559
    UniProtKB/TrEMBL
    F6Z4X6

  8. NM_001423443.1 → NP_001410372.1  opticin isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC131998, AC157924, FQ976559
    UniProtKB/TrEMBL
    F6Z4X6

  9. NM_001423444.1 → NP_001410373.1  opticin isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC131998
    UniProtKB/TrEMBL
    F6Z4X6, Q4KL49

  10. NM_001423445.1 → NP_001410374.1  opticin isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AC131998, AC157924, FQ976559

  11. NM_001423446.1 → NP_001410375.1  opticin isoform 8 precursor

    Status: VALIDATED

    Source sequence(s)
    AC131998

  12. NM_054076.4 → NP_473417.3  opticin isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC131998, AC157924, FQ976559
    Consensus CDS
    CCDS15299.2
    UniProtKB/Swiss-Prot
    Q8K3K2, Q91ZZ9, Q920A0
    UniProtKB/TrEMBL
    Q14BF5
    Related
    ENSMUSP00000120568.4, ENSMUST00000124051.10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    133824937..133837344 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254589.2 → XP_030110449.1  opticin isoform X4

    Conserved Domains (3) summary
    PRK15387
    Location:131 → 310
    PRK15387; type III secretion system effector E3 ubiquitin transferase SspH2
    sd00031
    Location:208 → 231
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:207 → 288
    LRR_8; Leucine rich repeat

  2. XM_011248028.4 → XP_011246330.1  opticin isoform X3

    UniProtKB/TrEMBL
    F6Z4X6
    Conserved Domains (3) summary
    COG4886
    Location:164 → 355
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:237 → 260
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:238 → 295
    LRR_8; Leucine rich repeat

  3. XM_036165400.1 → XP_036021293.1  opticin isoform X1

    Conserved Domains (3) summary
    sd00031
    Location:237 → 260
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:238 → 295
    LRR_8; Leucine rich repeat
    cd21340
    Location:221 → 373
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  4. XM_030254587.1 → XP_030110447.1  opticin isoform X2

    UniProtKB/TrEMBL
    E9PUR1, G3UVW2
    Conserved Domains (2) summary
    sd00033
    Location:204 → 227
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:188 → 360
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  5. XM_036165406.1 → XP_036021299.1  opticin isoform X5

    UniProtKB/TrEMBL
    F6Z4X6
    Conserved Domains (3) summary
    sd00031
    Location:204 → 227
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:205 → 262
    LRR_8; Leucine rich repeat
    cd21340
    Location:188 → 325
    PPP1R42; protein phosphatase 1 regulatory subunit 42

RNA

  1. XR_878322.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q920A0.2 GenPept UniProtKB/Swiss-Prot:Q920A0

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