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| Status |
Public on Apr 04, 2020 |
| Title |
BAP1 loss triggers DNA methylomic repatterning in highly aggressive Class 2 uveal melanomas [BeadChip 450K] |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
|
| Summary |
The strong association between BAP1 mutations and highly aggressive Class 2 uveal melanoma (UM) suggests that epigenetic alterations may play a significant role in tumor progression. Thus, we characterized the impact of BAP1 loss on the DNA methylome in UM.
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| Overall design |
Global DNA methylation was analyzed in 8 Class 1 and 4 Class 2 primary UMs and in 2 different UM cells (92.1, Mel202) engineered to inducibly deplete BAP1 with dox treatment. For the engineered cell lines, both uninduced and induced cell were analyzed with two replicates of all conditions.
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| |
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| Contributor(s) |
Harbour JW |
| Citation(s) |
31285370 |
| |
| Submission date |
Apr 26, 2019 |
| Last update date |
Apr 10, 2020 |
| Contact name |
Matthew G. Field |
| Organization name |
University of Miami
|
| Street address |
1501 NW 10th Avenue
|
| City |
Miami |
| State/province |
FL |
| ZIP/Postal code |
33136 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL13534 |
Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482) |
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| Samples (12)
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| This SubSeries is part of SuperSeries: |
| GSE130357 |
BAP1 loss triggers DNA methylomic repatterning in highly aggressive Class 2 uveal melanomas |
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| Relations |
| BioProject |
PRJNA539870 |
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