|
| Status |
Public on Mar 01, 2017 |
| Title |
Acquired resistance to BRAF-inhibitors restores melanoma tumor immune suppression |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The acquisition of resistance to BRAF-inhibitors results in MAPK-driven, CCL2-mediated repopulation of intratumoral myeloid-derived suppressor cells (MDSCs) in a mouse model of melanoma, and the depletion of MDSCs allows for effective immunotherapy against drug-resistant tumors.
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| |
|
| Overall design |
Gene expression and intrinsic subset assignment were measured in 16 mouse biopsies
|
| |
|
| Contributor(s) |
Steinberg SM, Martyanov V, Boni A, Turk MJ, Shabaneh TB, Li Z, Malik BT, Zhang P, Wood TA, Whitfield ML |
| Citation(s) |
28202513 |
| |
| Submission date |
Mar 14, 2016 |
| Last update date |
Feb 02, 2018 |
| Contact name |
Tammara Wood |
| E-mail(s) |
tammara.a.wood@dartmouth.edu
|
| Organization name |
Dartmouth Medical School
|
| Department |
Biomedical Data Science
|
| Lab |
Whitfield Lab
|
| Street address |
WTRB 674
|
| City |
Lebanon |
| State/province |
NH |
| ZIP/Postal code |
03756 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL10787 |
Agilent-028005 SurePrint G3 Mouse GE 8x60K Microarray (Probe Name version) |
|
| Samples (16)
|
|
| Relations |
| BioProject |
PRJNA315156 |
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