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Skin Fibroblastic Neoplasm

MedGen UID:
138097
•Concept ID:
C0349527
•
Neoplastic Process
Synonyms: Cutaneous Fibroblastic Neoplasm; Cutaneous Fibroblastic Tumor; Cutaneous Fibrocytic Neoplasm; Cutaneous Fibrocytic Tumor; Cutaneous Fibrous Tissue Neoplasm; Cutaneous fibrous tissue tumor; Cutaneous Fibrous Tissue Tumor; Fibrous tissue neoplasm of skin; Fibrous tissue tumor of skin; Skin Fibrous Tissue Neoplasm; Skin Fibrous Tissue Tumor
SNOMED CT: Fibrous tissue neoplasm of skin (254736006); Fibrous tissue tumor of skin (254736006); Cutaneous fibrous tissue tumor (254736006)

Definition

A neoplasm arising from the dermis. It is characterized by the presence of neoplastic fibroblasts. [from NCI]

Professional guidelines

PubMed

Surgical management of dermatofibrosarcoma protuberans.
Rust DJ, Kwinta BD, Geskin LJ, Samie FH, Remotti F, Yoon SS
J Surg Oncol 2023 Jul;128(1):87-96. Epub 2023 Mar 31 doi: 10.1002/jso.27258. PMID: 36999599
Dupuytren's Disease-Etiology and Treatment.
Ruettermann M, Hermann RM, Khatib-Chahidi K, Werker PMN
Dtsch Arztebl Int 2021 Nov 19;118(46):781-788. doi: 10.3238/arztebl.m2021.0325. PMID: 34702442Free PMC Article
Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma: Updates on Classification and Management.
Soleymani T, Aasi SZ, Novoa R, Hollmig ST
Dermatol Clin 2019 Jul;37(3):253-259. Epub 2019 Apr 16 doi: 10.1016/j.det.2019.02.001. PMID: 31084719

Recent clinical studies

Etiology

Myxoinflammatory Fibroblastic Sarcoma.
Wu H, Laskin WB
Surg Pathol Clin 2024 Mar;17(1):83-96. Epub 2023 Aug 8 doi: 10.1016/j.path.2023.07.003. PMID: 38278610
Dupuytren's Disease-Etiology and Treatment.
Ruettermann M, Hermann RM, Khatib-Chahidi K, Werker PMN
Dtsch Arztebl Int 2021 Nov 19;118(46):781-788. doi: 10.3238/arztebl.m2021.0325. PMID: 34702442Free PMC Article
Dermatofibrosarcoma Protuberans.
Allen A, Ahn C, Sangüeza OP
Dermatol Clin 2019 Oct;37(4):483-488. doi: 10.1016/j.det.2019.05.006. PMID: 31466588
Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma: Updates on Classification and Management.
Soleymani T, Aasi SZ, Novoa R, Hollmig ST
Dermatol Clin 2019 Jul;37(3):253-259. Epub 2019 Apr 16 doi: 10.1016/j.det.2019.02.001. PMID: 31084719
Fibrohistiocytic Tumors.
Romano RC, Fritchie KJ
Clin Lab Med 2017 Sep;37(3):603-631. Epub 2017 Jun 15 doi: 10.1016/j.cll.2017.05.007. PMID: 28802503

Diagnosis

Atypical Fibroxanthoma.
Chapman LW, Yu SS, Arron ST
Semin Cutan Med Surg 2019 Mar 1;38(1):E65-E66. doi: 10.12788/j.sder.2019.008. PMID: 31051027
Histologic Mimics of Basal Cell Carcinoma.
Stanoszek LM, Wang GY, Harms PW
Arch Pathol Lab Med 2017 Nov;141(11):1490-1502. doi: 10.5858/arpa.2017-0222-RA. PMID: 29072946
Dermatomyofibroma.
Campagnolo OA, Morais CF, Ughini MO, Aoki CM, Menegazzo M
An Bras Dermatol 2017 Jan-Feb;92(1):101-103. doi: 10.1590/abd1806-4841.20175189. PMID: 28225965Free PMC Article
Case for diagnosis.
Sampaio FM, Gualberto GV, Cerqueira FG, Cerqueira AM, Treu CM, Vargas TJ
An Bras Dermatol 2014 May-Jun;89(3):519-20. doi: 10.1590/abd1806-4841.20142507. PMID: 24937835Free PMC Article
Dermatofibrosarcoma protuberans.
Serra-Guillén C, Llombart B, Sanmartín O
Actas Dermosifiliogr 2012 Nov;103(9):762-77. Epub 2012 Jan 28 doi: 10.1016/j.ad.2011.10.007. PMID: 22285046

Therapy

Chronic Oral Lesions.
Bukhari AF, Farag AM, Treister NS
Dermatol Clin 2020 Oct;38(4):451-466. Epub 2020 Aug 11 doi: 10.1016/j.det.2020.05.006. PMID: 32892854
Dermatofibrosarcoma Protuberans.
Allen A, Ahn C, Sangüeza OP
Dermatol Clin 2019 Oct;37(4):483-488. doi: 10.1016/j.det.2019.05.006. PMID: 31466588
Complications of Treatment for Dupuytren Disease.
Eberlin KR, Mudgal CS
Hand Clin 2018 Aug;34(3):387-394. Epub 2018 Jun 8 doi: 10.1016/j.hcl.2018.03.007. PMID: 30012298
Infantile myofibromatosis.
Larralde M, Ferrari B, Martinez JP, Barbieri MAF, Méndez JH, Casas J
An Bras Dermatol 2017 Nov-Dec;92(6):854-857. doi: 10.1590/abd1806-4841.20175001. PMID: 29364448Free PMC Article
Rare skin cancers.
Kanitakis J
Cancer Treat Res 2009;146:323-8. doi: 10.1007/978-0-387-78574-5_26. PMID: 19415213

Prognosis

Pleomorphic Dermal Sarcoma.
Saleh JS, Whittington CP, Bresler SC, Patel RM
Surg Pathol Clin 2024 Mar;17(1):153-158. Epub 2023 Aug 5 doi: 10.1016/j.path.2023.06.007. PMID: 38278604
Dupuytren's Disease-Etiology and Treatment.
Ruettermann M, Hermann RM, Khatib-Chahidi K, Werker PMN
Dtsch Arztebl Int 2021 Nov 19;118(46):781-788. doi: 10.3238/arztebl.m2021.0325. PMID: 34702442Free PMC Article
Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma: Updates on Classification and Management.
Soleymani T, Aasi SZ, Novoa R, Hollmig ST
Dermatol Clin 2019 Jul;37(3):253-259. Epub 2019 Apr 16 doi: 10.1016/j.det.2019.02.001. PMID: 31084719
Cutaneous mesenchymal tumours: an update.
Mentzel T
Pathology 2014 Feb;46(2):149-59. doi: 10.1097/PAT.0000000000000046. PMID: 24378387
Dermatofibrosarcoma protuberans.
Mendenhall WM, Zlotecki RA, Scarborough MT
Cancer 2004 Dec 1;101(11):2503-8. doi: 10.1002/cncr.20678. PMID: 15503305

Clinical prediction guides

Dupuytren's Disease-Etiology and Treatment.
Ruettermann M, Hermann RM, Khatib-Chahidi K, Werker PMN
Dtsch Arztebl Int 2021 Nov 19;118(46):781-788. doi: 10.3238/arztebl.m2021.0325. PMID: 34702442Free PMC Article
Scanning electron microscopy of dermatofibroma.
Quintana FSL, Almeida HL Jr, Ruas CP, Jorge VM
An Bras Dermatol 2019 Jul 29;94(3):358-360. doi: 10.1590/abd1806-4841.20197906. PMID: 31365670Free PMC Article
Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma: Updates on Classification and Management.
Soleymani T, Aasi SZ, Novoa R, Hollmig ST
Dermatol Clin 2019 Jul;37(3):253-259. Epub 2019 Apr 16 doi: 10.1016/j.det.2019.02.001. PMID: 31084719
Atrophic dermatofibroma.
Ohnishi T, Sasaki M, Nakai K, Watanabe S
J Eur Acad Dermatol Venereol 2004 Sep;18(5):580-3. doi: 10.1111/j.1468-3083.2004.00975.x. PMID: 15324399
Granular cell dermatofibroma.
Soyer HP, Metze D, Kerl H
Am J Dermatopathol 1997 Apr;19(2):168-73. doi: 10.1097/00000372-199704000-00011. PMID: 9129702

Recent systematic reviews

Full-thickness skin grafting in preventing recurrence of Dupuytren's disease: A systematic review.
De Ketele A, Degreef I
Hand Surg Rehabil 2023 Sep;42(4):273-283. Epub 2023 Jun 17 doi: 10.1016/j.hansur.2023.06.002. PMID: 37336491
Dermatofibrosarcoma Protuberans Recurrence After Wide Local Excision Versus Mohs Micrographic Surgery: A Systematic Review and Meta-Analysis.
Martin ECS, Vyas KS, Batbold S, Erwin PJ, Brewer JD
Dermatol Surg 2022 May 1;48(5):479-485. Epub 2022 Mar 30 doi: 10.1097/DSS.0000000000003411. PMID: 35353755
Surgical excision margins for fibrohistiocytic tumors, including atypical fibroxanthoma and undifferentiated pleomorphic sarcoma: A probability model based on a systematic review.
Jibbe A, Worley B, Miller CH, Alam M
J Am Acad Dermatol 2022 Oct;87(4):833-840. Epub 2021 Sep 26 doi: 10.1016/j.jaad.2021.09.036. PMID: 34587553
Ophthalmologic aspects of Dermatofibrosarcoma Protuberans: A systematic review in the context of a rare case of primary orbital involvement.
Eshraghi B, Jahanbani-Ardakani HR, Abtahi SM, Abtahi SH
J Fr Ophtalmol 2019 Oct;42(8):913-924. Epub 2019 Apr 10 doi: 10.1016/j.jfo.2018.11.012. PMID: 30981544
Efficacy of Mohs micrographic surgery for the treatment of dermatofibrosarcoma protuberans: systematic review.
Foroozan M, Sei JF, Amini M, Beauchet A, Saiag P
Arch Dermatol 2012 Sep;148(9):1055-63. doi: 10.1001/archdermatol.2012.1440. PMID: 22986859

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