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Links from GEO DataSets

Items: 19

1.

Genes regulated by miR-181c

(Submitter supplied) We found frequently down-regulation of microRNA-181c in human gastric cancer cases. To identify the potential target of miR-181c, we introduced miR-181c into a gastric cancer cell line KATO-III and analyzed significant changes of gene expression which was induced after introducing miR-181c. Keywords: dose response
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
1 Sample
Download data: TXT
Series
Accession:
GSE16239
ID:
200016239
2.

MicroRNAs regulated by DAC

(Submitter supplied) Aberrant expression of microRNA (miRNA) has been reported in various cancers. To clarify the role of miRNA in gastric carcinogenesis, we performed miRNA microarray analysis and investigated expressional changes of miRNAs in a 5-aza-2'-deoxycytidine (DAC)-treated gastric cancer cell line, KATO-ІІІ.
Organism:
Mus musculus; Rattus norvegicus; Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL5106
2 Samples
Download data: TIFF, TXT
Series
Accession:
GSE16006
ID:
200016006
3.

Genes regulated by miR-34b/c and DAC

(Submitter supplied) We found frequent epigenetic silencing of microRNA-34b/c in human colorectal cancer. Introduction of miR-34b/c into a colorectal cancer cell line induced significant changes in gene expression profile. We also found overlap between the genes downregulated by miR-34b/c and those downregulated by DAC. Keywords: dose response
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
5 Samples
Download data: TXT
Series
Accession:
GSE10455
ID:
200010455
4.

Gene expression signatures in GIST-T1 cells transfected with miR-34a and miR-335 mimic molecules

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16699
8 Samples
Download data: TXT
Series
Accession:
GSE68743
ID:
200068743
5.

Gene expression signatures in GIST-T1 cells transfected with a miR-335 mimic molecule

(Submitter supplied) To clarify the effect of miRNAs, we carried out a gene expression microarray analysis using GIST-T1 cells transfected with a miR-335 mimic or a negative control. We found that 1,095 probe sets (853 unique genes) were downregulated (>1.5-fold) by ectopic miR-335 expression.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16699
4 Samples
Download data: TXT
Series
Accession:
GSE68742
ID:
200068742
6.

Gene expression signatures in GIST-T1 cells transfected with a miR-34a mimic molecule

(Submitter supplied) To clarify the effect of miRNAs, we carried out a gene expression microarray analysis using GIST-T1 cells transfected with a miR-34a mimic or a negative control. We found that 2,621 probe sets (1,933 unique genes) were downregulated (>1.5-fold) by ectopic miR-34a expression, including PDGFRA gene which was previously reported as a miR-34a target gene.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16699
4 Samples
Download data: TXT
Series
Accession:
GSE68740
ID:
200068740
7.

Gene expression signatures in a human bladder cancer cell line SW780 transfected with miR-137 precursor molecule

(Submitter supplied) To clarify the effect of miRNAs, we carried out a gene expression microarray analysis of SW780 cells transfected with a miR-137 precursor or a negative control. We found that 1,326 probe sets (1,016 unique genes) were downregulated (>2-fold) by ectopic miR-137 expression, including the previously reported miR-137 target genes CDK6, CDC42 and AURKA. Moreover, Gene Ontology analysis revealed that genes related to the cell cycle were significantly enriched among the affected genes.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13607
2 Samples
Download data: TXT
Series
Accession:
GSE41760
ID:
200041760
8.

Epigenome signatures during gastric carcinogenesis based on next generation sequencing

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome variation profiling by SNP array; SNP genotyping by SNP array; Methylation profiling by high throughput sequencing
Platforms:
GPL6801 GPL9115
12 Samples
Download data: BED, CEL, CHP
Series
Accession:
GSE55160
ID:
200055160
9.

Epigenome signatures during gastric carcinogenesis based on next generation sequencing analysis [Bisulfite-Seq]

(Submitter supplied) Because gastric cancer cells already had genetic and epigenetic alterations which can affect the gastric carcinogenesis, we tried to characterize genetic and epigenetic changes during gastric carcinogenesis. To do this, we performed MBD sequencing and RRBS sequencing.
Organism:
Homo sapiens
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL9115
3 Samples
Download data: BED
Series
Accession:
GSE55159
ID:
200055159
10.

Epigenome signatures during gastric carcinogenesis based on next generation sequencing analysis [MBD-Seq]

(Submitter supplied) Because gastric cancer cells already had genetic and epigenetic alterations which can affect the gastric carcinogenesis, we tried to characterize genetic and epigenetic changes during gastric carcinogenesis. To do this, we performed MBD sequencing and RRBS sequencing.
Organism:
Homo sapiens
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL9115
3 Samples
Download data: BED
Series
Accession:
GSE55157
ID:
200055157
11.

Epigenome signatures during gastric carcinogenesis based on next generation sequencing [Affymetrix]

(Submitter supplied) Because gastric cancer cells already had genetic and epigenetic alterations which can affect the gastric carcinogenesis, we tried to characterize genetic and epigenetic changes during gastric carcinogenesis. To do this, we performed SNP array.
Organism:
Homo sapiens
Type:
SNP genotyping by SNP array; Genome variation profiling by SNP array
Platform:
GPL6801
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE55153
ID:
200055153
12.

Genes regulated by SOX2 overexpression in gastric cancer cells

(Submitter supplied) To identify candidate downstream target genes of SOX2 in gastric cancer cells, we transiently expressed exogenous SOX2 in a gastric cancer cell line NUGC3 and analyzed significant changes of gene expression.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
1 Sample
Download data: TIFF, TXT
Series
Accession:
GSE23589
ID:
200023589
13.

Modulation of the osteosarcoma expression phenotype by miRNAs

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array; Expression profiling by array
Platforms:
GPL8227 GPL13376
46 Samples
Download data: TXT
Series
Accession:
GSE28425
ID:
200028425
14.

Modulation of the osteosarcoma expression phenotype by miRNAs [Illumina]

(Submitter supplied) Background: Osteosarcomas are the most common primary malignant tumors of bone and show multiple and complex genomic aberrations. miRNAs are non-coding RNAs capable of regulating gene expression at the post transcriptional level, and miRNAs and their target genes may represent novel therapeutic targets or biomarkers for osteosarcoma. In order to investigate the involvement of miRNAs in osteosarcoma development, global microarray analyses of a panel of 19 human osteosarcoma cell lines was performed. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13376
23 Samples
Download data: TXT
Series
Accession:
GSE28424
ID:
200028424
15.

Modulation of the osteosarcoma expression phenotype by miRNAs [Agilent]

(Submitter supplied) Background: Osteosarcomas are the most common primary malignant tumors of bone and show multiple and complex genomic aberrations. miRNAs are non-coding RNAs capable of regulating gene expression at the post transcriptional level, and miRNAs and their target genes may represent novel therapeutic targets or biomarkers for osteosarcoma. In order to investigate the involvement of miRNAs in osteosarcoma development, global microarray analyses of a panel of 19 human osteosarcoma cell lines was performed. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL8227
23 Samples
Download data: TXT
Series
Accession:
GSE28423
ID:
200028423
16.

Identification and functional analysis of epigenetically silenced microRNAs in colorectal cancer cells

(Submitter supplied) Abnormal miRNA expression has been linked to the development and progression of human cancers, and such dysregulation can result from aberrant DNA methylation. We combined the analysis of miRNA expression data deposited with empirical DNA methylation data in HCT116 and DKO colon cancer cells (SRA accession# SRP001414) to identify novel DNA methylation regulated miRNAs. ABSTRACT: Abnormal microRNA (miRNA) expression has been linked to the development and progression of several human cancers, and such dysregulation can result from aberrant DNA methylation. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL8179
6 Samples
Download data: TXT
Series
Accession:
GSE26819
ID:
200026819
17.

miR-181c is up-regulated in monoMAC cells related to increased cell death

(Submitter supplied) Somatic and germline mutations in GATA2 were recently identified in patients diagnosed with monoMAC, the hallmarks of which include monocytopenia, B-cell and NK-cell lymphopenia, susceptibility to opportunistic infections (e.g. MAC), and a strong propensity to develop hypocellular MDS/AML or CMML. GATA2 mutations are thought to result in loss of function or haploinsufficiency, but the precise mechanism for the development of cytopenias, immunodeficiency, and susceptibility to MDS remains to be elucidated. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL10656
21 Samples
Download data: TXT
Series
Accession:
GSE51132
ID:
200051132
18.

Evaluation of gene expression profile in postmortem brain with Alzheimer´s disease-type neuropathological changes

(Submitter supplied) Unravel the mechanisms underlying brain aging and Alzheimer´s disease (AD) has been difficult because of complexity of the networks that drive these aging-related changes. Analysis of the gene expression in the brain is a valuable tool to study the function of the brain under normal and pathological conditions. Gene microarray technology allows massively parallel analysis of most genes expressed in a tissue, and therefore is an important research tool that potentially can provide the investigative power needed to address the complexity of brain aging and neurodegenerative processes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL1930
128 Samples
Download data
Series
Accession:
GSE13214
ID:
200013214
19.

nc886, a noncoding RNA of anti-proliferative role, is suppressed by CpG DNA methylation in human gastric cancer

(Submitter supplied) nc886 is a 101 nucleotides long non-coding RNA that is also known as a precursor microRNA or a vault RNA. nc886 has been suggested to be a tumor suppressor, mainly inferred by its expression pattern as well as its genomic location at human chromosome 5q31, a locus for a tumor suppressor gene(s). In order to understand potential roles of nc886 in gastric cancer, we performed the knockdown of nc886 in nonmalignant HFE-145 cells and identified and analyzed genes whose expression is activated by nc886 knockdown in gastric cancer.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
6 Samples
Download data: TXT
Series
Accession:
GSE51067
ID:
200051067
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