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TP53 tumor protein p53 [ Homo sapiens (human) ]

Gene ID: 7157, updated on 18-Nov-2024

Summary

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Official Symbol: TP53provided by HGNC
Official Full Name: tumor protein p53provided by HGNC
Primary source: HGNC:HGNC:11998
See related: Ensembl:ENSG00000141510 MIM:191170; AllianceGenome:HGNC:11998
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: P53; BCC7; LFS1; BMFS5; TRP53
Summary: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
Expression: Ubiquitous expression in spleen (RPKM 13.2), lymph node (RPKM 13.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

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See TP53 in Genome Data Viewer

Location:: 17p13.1

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (7668421..7687490, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (7572544..7591594, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (7571739..7590808, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GRAIL1 Stabilizes Misfolded Mutant p53 through a Ubiquitin Ligase-Independent, Chaperone Regulatory Function.
Title: GRAIL1 Stabilizes Misfolded Mutant p53 through a Ubiquitin Ligase-Independent, Chaperone Regulatory Function.
ZNF8 promotes progression of gastrointestinal cancers via a p53-dependent mechanism.
Title: ZNF8 promotes progression of gastrointestinal cancers via a p53-dependent mechanism.
The role of p53 in male infertility.
Title: The role of p53 in male infertility.
Atox1-cyclin D1 loop activity is critical for survival of tumor cells with inactivated TP53.
Title: Atox1-cyclin D1 loop activity is critical for survival of tumor cells with inactivated TP53.
Temporal regulation of gene expression through integration of p53 dynamics and modifications.
Title: Temporal regulation of gene expression through integration of p53 dynamics and modifications.
Working title: Molecular involvement of p53-MDM2 interactome in gastrointestinal cancers.
Title: Working title: Molecular involvement of p53-MDM2 interactome in gastrointestinal cancers.
Disrupting the interaction between a p53 gain-of-function mutant and the transcriptional co-activator PC4 reverses drug resistance in cancer cells.
Title: Disrupting the interaction between a p53 gain-of-function mutant and the transcriptional co-activator PC4 reverses drug resistance in cancer cells.
The mitochondrial enzyme pyruvate carboxylase restricts pancreatic beta-cell senescence by blocking p53 activation.
Title: The mitochondrial enzyme pyruvate carboxylase restricts pancreatic β-cell senescence by blocking p53 activation.
Entrainment and multi-stability of the p53 oscillator in human cells.
Title: Entrainment and multi-stability of the p53 oscillator in human cells.
Case series of Li-Fraumeni syndrome: carcinogenic mechanisms in breast cancer with TP53 pathogenic variant carriers.
Title: Case series of Li-Fraumeni syndrome: carcinogenic mechanisms in breast cancer with TP53 pathogenic variant carriers.

Submit: New GeneRIF Correction See all GeneRIFs (9578)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Professional guidelines

Description
Professional guideline ACMG 2013 The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in TP53 that are pathogenic or expected to be pathogenic. GuidelinePubMed

Associated conditions

Description	Tests
Adrenocortical carcinoma, hereditary MedGen: C1859972 OMIM: 202300 GeneReviews: Not available	Compare labs
Basal cell carcinoma, susceptibility to, 7 MedGen: C3553606 OMIM: 614740 GeneReviews: Not available	Compare labs
Bone marrow failure syndrome 5 MedGen: C4748488 OMIM: 618165 GeneReviews: Not available	Compare labs
Bone osteosarcoma MedGen: C0585442 OMIM: 259500 GeneReviews: Not available	Compare labs
Carcinoma of pancreas MedGen: C0235974 GeneReviews: Not available	Compare labs
Choroid plexus papilloma MedGen: C0205770 OMIM: 260500 GeneReviews: Not available	Compare labs
Colorectal cancer MedGen: C0346629 OMIM: 114500 GeneReviews: Lynch Syndrome	Compare labs
Familial cancer of breast MedGen: C0346153 OMIM: 114480 GeneReviews: BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer	Compare labs
Glioma susceptibility 1 MedGen: C2750850 OMIM: 137800 GeneReviews: Not available	Compare labs
Hepatocellular carcinoma MedGen: C2239176 OMIM: 114550 GeneReviews: Not available	Compare labs
Li-Fraumeni syndrome MedGen: C0085390 GeneReviews: Li-Fraumeni Syndrome	Compare labs
Li-Fraumeni syndrome 1 MedGen: C1835398 OMIM: 151623 GeneReviews: Wilms Tumor Predisposition, Li-Fraumeni Syndrome	Compare labs
Nasopharyngeal carcinoma MedGen: C2931822 OMIM: 607107 GeneReviews: Not available	Compare labs

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2021-11-10) ClinGen Genome Curation Page Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2021-11-10) ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation. EBI GWAS Catalog EBI GWAS CatalogPubMed
A germline variant in the TP53 polyadenylation signal confers cancer susceptibility. EBI GWAS Catalog EBI GWAS CatalogPubMed
Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma. EBI GWAS Catalog EBI GWAS CatalogPubMed
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Latent HIV infection increases TP53 (p53) expression and phosphorylation	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 Env gp120 induces TP53 (p53) via binding to the CXCR4 co-receptor	PubMed
	env	HIV-1 Env gp120 treatment activates TP53 (p53) which contributes to the upregulation of the mitochondrial redox enzyme PRODH (POX)	PubMed
	env	HIV-1 gp120 is potentially cytotoxic to human cells through the induction of p53, which may eventually lead to induction of apoptosis	PubMed
	env	Caspase 8 proteolytic target protein Bid is cleaved and undergoes mitochondrial translocation in gp120-treated p53 expression neurons	PubMed
	env	HIV-1 gp120-mediated activation of caspase 8 occurs in a p53 independent manner, while HIV-1 gp120-mediated activation of caspase 3 requires p53	PubMed
	env	Tumor suppressor protein PML is required for the activating phosphorylation of ATM, p38 MAPK, and p53 in HIV-1 Env-elicited syncytia	PubMed
	env	p38 MAPK-mediated p53 phosphorylation on serine 46 contributes to apoptosis induced by the HIV-1 envelope glycoprotein complex (gp120/gp41)	PubMed
	env	Syncytial apoptosis mediated by the fusion of cells expressing HIV-1 gp120 with cells expressing the CD4/CXCR4 receptor/coreceptor complex causes phosphorylation of p53 on serine 15 and Bax upregulation	PubMed
Nef	nef	Assays with phage-displayed Nef from HIV-1 NL4-3 have been used to identify a series of guanidine alkaloid-based inhibitors of Nef interactions with p53, actin, and p56(lck)	PubMed
	nef	HIV-1 Nef binds directly to tumor suppressor protein p53; an N-terminal 57-residue fragment of Nef (Nef 1-57) contains the p53-binding domain	PubMed
Pr55(Gag)	gag	HIV-1 infection upregulates the expression of p53 in CD4+ T cells and PBMCs in terms of increased cellular HIV-1 Gag/p24 levels	PubMed
Rev	rev	HIV-1 Tat reactivates latent HIV-1 proviruses in J1.1 and ACH-2 cell lines and promotes p53-induced apoptosis in the presence of Rev	PubMed
Tat	tat	Expression of p53 inhibits HIV-1 Tat activity in a dose-dependent manner and PKR plays a crucial role in p53-mediated Tat suppression in p53-/- cells	PubMed
	tat	Wild-type p53 is a potent inhibitor of HIV-1 Tat transactivation of the HIV-1 LTR promoter in Jurkat T cells and Hep3B cells	PubMed
	tat	HIV-1 Tat downregulates the expression of p53, suggesting a mechanism for HIV-1-mediated transformation of infected cells	PubMed
	tat	Treatment with HIV-Tat and morphine activates extracellular signal-regulated kinase-1/2 (ERK1/2), upregulates p53 and p21 levels, and downregulates cyclin D1 and Akt levels in human fetal brain-derived neural precursor cells	PubMed
	tat	HIV-1 Tat activates the p53 transcription factor pathway leading to the induction of endogenous p53 and p73 in neuronal cells	PubMed
	tat	HIV-1 Tat inhibits SIRT1 and increases acetylation of p53, which leads to activation of p21 and BAX in HeLa-CD4+ cells	PubMed
	tat	When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA	PubMed
	tat	HIV-1 Tat reactivates latent HIV-1 proviruses in J1.1 and ACH-2 cell lines and promotes p53-induced apoptosis in the presence of Rev	PubMed
	tat	The p53 tetramerization domain (residues 326-355) binds directly to residues 1-35 and 47-57 in HIV-1 Tat as evidenced by using peptide mapping, fluorescence anisotropy, and NMR spectroscopy	PubMed
	tat	In the absence of either p53 or p73, Tat fails to induce dendritic retraction or to activate the proapoptotic proteins, such as Bax	PubMed
	tat	Activation of p38 MAPK in HIV-infected cells mediated by Tat leads to the phosphorylation of p53 which subsequently upregulates CAV-1 expression	PubMed
	tat	HIV-1 Tat binds to p53, an interaction mediated by the basic region of Tat (amino acids 49-57) and the acidic O2 domain of p53 (amino acids 341-354	PubMed
	tat	Supernatants from HIV-1 Tat-transfected monocytoid cells induces p53 expression in neurons, indicating a role for Tat in the neuropathogenesis of HIV-1	PubMed
	tat	HIV-1 Tat inhibits p53-responsive transcription by binding to histone acetyltransferases and repressing the acetylation of p53 on residue Lys-320, alluding to a mechanism whereby Tat may impair p53 functions, thus favoring the establishment of neoplasia	PubMed
	tat	HIV-1 Tat and p53 cooperate in the activation of HIV-1 gene expression in SaOS2 cells	PubMed
Vif	vif	HIV-1 Vif stabilizes TP53 by blocking MDM2-induced ubiquitination and inhibits MDM2-mediated nuclear export of TP53, leading to support viral replication through inducing G2 cell cycle arrest	PubMed
	vif	The N-terminal region (residues 1-50) of HIV-1 Vif is important for binding to TP53	PubMed
Vpr	vpr	HIV-1 Vpr interacts with p53 in a complex with the transcription factor Sp1 that modulates viral gene transcription from the HIV-1 LTR promoter	PubMed
	vpr	HIV-1 Vpr downregulates proliferation-associated protein 2G4 (PA2G4) and upregulates p53 in glioblastoma U87MG cells	PubMed
	vpr	Exposure of cultured human primary astrocytes to HIV-1 Vpr induces p53 up-regulation, loss of mitochondrial membrane potential, and caspase-6 activation followed by cell injury	PubMed
	vpr	Soluble HIV-1 Vpr causes neuronal apoptosis, involving cytochrome c extravasation, p53 induction, and activation of caspase-9	PubMed
	vpr	HIV-1 Vpr inhibits the interaction of p53 and Rad51 in chromatin fractions, as observed under irradiation-induced DNA double-strand breaks	PubMed
	vpr	Results from GST pull-down assays show the association of Vpr with p53 in extracts containing Sp1, suggesting the physical interaction of Vpr with Sp1 and p53 could modulate transcriptional activity of p21	PubMed
	vpr	Activation of p21/Waf1/Cip1 by HIV-1 Vpr appears to be regulated by p53	PubMed
	vpr	HIV-1 Vpr can neutralize inhibitory effects of the human homologue of yeast Rad23 protein A (hHR23A) on p53, thereby activating p53 transcriptional activity	PubMed
	vpr	Overexpression of p53 decreases the level of activation of the viral LTR promoter by HIV-1 Vpr	PubMed
Vpu	vpu	HIV-1 Vpu expression results in significant upregulation of phosphorylated p53. Vpu contributes to p53-dependent apoptosis in HIV-1-infected cells	PubMed
	vpu	HIV-1 Vpu expression leads to stabilization and upregulation of p53 via inhibiting association of p53 with beta-TrCP and its subsequent ubiquitination	PubMed
integrase	gag-pol	HIV-1 IN-mediated proviral DNA integration triggers cell death during HIV-1 infection. The mechanism of killing during viral integration involves activation of DNA-PK, which causes phosphorylation of p53 and histone gammaH2AX	PubMed
reverse transcriptase	gag-pol	Tumor suppressor protein p53 displays 3' --> 5' exonuclease activity, and interaction of p53 with HIV-1 reverse transcriptase (RT) can provide a proofreading function for HIV-1 RT	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:604633 (e-PCR)
- UniSTS:158212

GDB:605513 (e-PCR)
- UniSTS:158213

PMC340938P3 (e-PCR)
- UniSTS:273171

GDB:606441 (e-PCR)
- UniSTS:158229

PMC105081P1 (e-PCR)
- UniSTS:270116

D17S1678 (e-PCR)
- UniSTS:82485

PMC122799P1 (e-PCR)
- UniSTS:270407

PMC122799P2 (e-PCR)
- UniSTS:270408

GDB:177724 (e-PCR)
- UniSTS:154952

PMC122799P3 (e-PCR)
- UniSTS:270409

TP53_278 (e-PCR)
- UniSTS:277840

GDB:177797 (e-PCR)
- UniSTS:154963

GDB:177814 (e-PCR)
- UniSTS:154969

GDB:227151 (e-PCR)
- UniSTS:156250

WI-20715 (e-PCR)
- UniSTS:59997

GDB:181271 (e-PCR)
- UniSTS:155232

GDB:181272 (e-PCR)
- UniSTS:155233

GDB:186560 (e-PCR)
- UniSTS:155496

GDB:363686 (e-PCR)
- UniSTS:156783

GDB:363689 (e-PCR)
- UniSTS:156784

GDB:363692 (e-PCR)
- UniSTS:156785

D1S1423 (e-PCR)
- UniSTS:149619

GDB:363698 (e-PCR)
- UniSTS:156787

GDB:363701 (e-PCR)
- UniSTS:156788

GDB:363704 (e-PCR)
- UniSTS:156789

GDB:363724 (e-PCR)
- UniSTS:156790

GDB:363795 (e-PCR)
- UniSTS:156792

GDB:186921 (e-PCR)
- UniSTS:155522

GDB:186984 (e-PCR)
- UniSTS:155527

GDB:178567 (e-PCR)
- UniSTS:155019

D11S3114 (e-PCR)
- UniSTS:152207

D17S1506E (e-PCR)
- UniSTS:151711

GDB:316876 (e-PCR)
- UniSTS:156580

GDB:181608 (e-PCR)
- UniSTS:155314

PMC135765P1 (e-PCR)
- UniSTS:270771

PMC135765P2 (e-PCR)
- UniSTS:270772

GDB:188738 (e-PCR)
- UniSTS:155578

PMC22021P1 (e-PCR)
- UniSTS:272087

PMC22021P2 (e-PCR)
- UniSTS:272088

PMC22021P3 (e-PCR)
- UniSTS:272089

PMC22021P4 (e-PCR)
- UniSTS:272090

GDB:190076 (e-PCR)
- UniSTS:155620

PMC310707P2 (e-PCR)
- UniSTS:272633

PMC60253P1 (e-PCR)
- UniSTS:273402

PMC156059P1 (e-PCR)
- UniSTS:271356

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	EXP Inferred from Experiment more info	PubMed
enables ATP-dependent DNA/DNA annealing activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables MDM2/MDM4 family protein binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables TFIID-class transcription factor complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables copper ion binding	IDA Inferred from Direct Assay more info	PubMed
enables core promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables disordered domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables general transcription initiation factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone deacetylase regulator activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular condensate scaffold activity	IDA Inferred from Direct Assay more info	PubMed
enables molecular function activator activity	EXP Inferred from Experiment more info	PubMed
enables molecular function activator activity	IPI Inferred from Physical Interaction more info	PubMed
enables p53 binding	IPI Inferred from Physical Interaction more info	PubMed
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 2A binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase binding	EXP Inferred from Experiment more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell lineage commitment	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA damage response, signal transduction by p53 class mediator	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA damage response, signal transduction by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ER overload response	IDA Inferred from Direct Assay more info	PubMed
involved_in Ras protein signal transduction	IEP Inferred from Expression Pattern more info	PubMed
involved_in T cell differentiation in thymus	IEA Inferred from Electronic Annotation more info
involved_in T cell lineage commitment	IEA Inferred from Electronic Annotation more info
involved_in T cell proliferation involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bone marrow development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cardiac septum morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to UV-C	IEA Inferred from Electronic Annotation more info
involved_in cellular response to actinomycin D	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to gamma radiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to glucose starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to glucose starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to ionizing radiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular senescence	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cerebellum development	IEA Inferred from Electronic Annotation more info
involved_in chromosome organization	IEA Inferred from Electronic Annotation more info
involved_in circadian behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in determination of adult lifespan	ISS Inferred from Sequence or Structural Similarity more info
involved_in double-strand break repair	IEA Inferred from Electronic Annotation more info
involved_in embryonic organ development	IEA Inferred from Electronic Annotation more info
involved_in entrainment of circadian clock by photoperiod	ISS Inferred from Sequence or Structural Similarity more info
involved_in fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in gastrulation	IEA Inferred from Electronic Annotation more info
involved_in glial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in glucose catabolic process to lactate via pyruvate	IEA Inferred from Electronic Annotation more info
involved_in hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IDA Inferred from Direct Assay more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IDA Inferred from Direct Assay more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in mRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial DNA repair	IEA Inferred from Electronic Annotation more info
involved_in mitophagy	IEA Inferred from Electronic Annotation more info
involved_in mitotic G1 DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism growth	IEA Inferred from Electronic Annotation more info
involved_in necroptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA replication	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of G1 to G0 transition	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of G1 to G0 transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of glucose catabolic process to lactate via pyruvate	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of helicase activity	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of miRNA processing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mitophagy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of pentose-phosphate shunt	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of proteolysis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of stem cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of telomere maintenance via telomerase	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in nucleotide-excision repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oligodendrocyte apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in oxidative stress-induced premature senescence	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cardiac muscle cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cellular senescence	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cellular senescence	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of execution phase of apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of miRNA transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of miRNA transcription	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of miRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of miRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitochondrial membrane permeability	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of programmed necrotic cell death	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of release of cytochrome c from mitochondria	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of thymocyte apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
involved_in protein tetramerization	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in rRNA transcription	IEA Inferred from Electronic Annotation more info
involved_in reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA damage response, signal transduction by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_negative_effect regulation of cell cycle G2/M phase transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of fibroblast apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of intrinsic apoptotic signaling pathway by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitochondrial membrane permeability involved in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of tissue remodeling	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in release of cytochrome c from mitochondria	IEA Inferred from Electronic Annotation more info
involved_in replicative senescence	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to X-ray	IEA Inferred from Electronic Annotation more info
involved_in response to antibiotic	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to gamma radiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ischemia	IEA Inferred from Electronic Annotation more info
involved_in response to salt stress	IEA Inferred from Electronic Annotation more info
involved_in signal transduction by p53 class mediator	IDA Inferred from Direct Assay more info	PubMed
involved_in somitogenesis	IEA Inferred from Electronic Annotation more info
involved_in stem cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in thymocyte apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation-coupled chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in tumor necrosis factor-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in type II interferon-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in viral process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in PML body	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IMP Inferred from Mutant Phenotype more info	PubMed
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in germ cell nucleus	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with nuclear body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IMP Inferred from Mutant Phenotype more info	PubMed
located_in replication fork	IEA Inferred from Electronic Annotation more info
located_in site of double-strand break	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IGI Inferred from Genetic Interaction more info	PubMed
part_of transcription repressor complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: cellular tumor antigen p53

Names: antigen NY-CO-13; mutant tumor protein 53; phosphoprotein p53; transformation-related protein 53; tumor protein 53; tumor supressor p53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_017013.2 RefSeqGene

Range

5001..24149

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_321

mRNA and Protein(s)

NM_000546.6 → NP_000537.3 cellular tumor antigen p53 isoform a

See identical proteins and their annotated locations for NP_000537.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (a, also known as p53alpha) results from translation initiation at the upstream start codon. Both variants 1 and 2 encode isoform a, which is the longest isoform.

Source sequence(s)

AK223026, DA453049, X02469

Consensus CDS

CCDS11118.1

UniProtKB/Swiss-Prot

P04637, Q15086, Q15087, Q15088, Q16535, Q16807, Q16808, Q16809, Q16810, Q16811, Q16848, Q2XN98, Q3LRW1, Q3LRW2, Q3LRW3, Q3LRW4, Q3LRW5, Q86UG1, Q8J016, Q99659, Q9BTM4, Q9HAQ8, Q9NP68, Q9NPJ2, Q9NZD0, Q9UBI2, Q9UQ61

UniProtKB/TrEMBL

A0A386NC20, A0A386NC22, A0A386NC55, A0A386NC62, A0A386NCA6, A0A386NCB1, A0A386NCU2, A0A386NCW8, A0A386NCX4, A0A386NDA8, A0A386NDB3, A0A386NFX3, A0A386NFY2, A0A386NG45, K7PPA8, K7PPU4

Related

ENSP00000269305.4, ENST00000269305.9

Conserved Domains (4) summary

cd08367
Location:109 → 288

P53; P53 DNA-binding domain

pfam18521
Location:35 → 59

TAD2; Transactivation domain 2

pfam07710
Location:319 → 355

P53_tetramer; P53 tetramerisation motif

pfam08563
Location:6 → 30

P53_TAD; P53 transactivation motif
NM_001126112.3 → NP_001119584.1 cellular tumor antigen p53 isoform a

See identical proteins and their annotated locations for NP_001119584.1

Status: REVIEWED

Source sequence(s)

AC007421, AC087388

Consensus CDS

CCDS11118.1

UniProtKB/Swiss-Prot

P04637, Q15086, Q15087, Q15088, Q16535, Q16807, Q16808, Q16809, Q16810, Q16811, Q16848, Q2XN98, Q3LRW1, Q3LRW2, Q3LRW3, Q3LRW4, Q3LRW5, Q86UG1, Q8J016, Q99659, Q9BTM4, Q9HAQ8, Q9NP68, Q9NPJ2, Q9NZD0, Q9UBI2, Q9UQ61

UniProtKB/TrEMBL

A0A386NC20, A0A386NC22, A0A386NC55, A0A386NC62, A0A386NCA6, A0A386NCB1, A0A386NCU2, A0A386NCW8, A0A386NCX4, A0A386NDA8, A0A386NDB3, A0A386NFX3, A0A386NFY2, A0A386NG45, K7PPA8, K7PPU4

Related

ENSP00000391478.2, ENST00000445888.6

Conserved Domains (4) summary

cd08367
Location:109 → 288

P53; P53 DNA-binding domain

pfam18521
Location:35 → 59

TAD2; Transactivation domain 2

pfam07710
Location:319 → 355

P53_tetramer; P53 tetramerisation motif

pfam08563
Location:6 → 30

P53_TAD; P53 transactivation motif
NM_001126113.3 → NP_001119585.1 cellular tumor antigen p53 isoform c

See identical proteins and their annotated locations for NP_001119585.1

Status: REVIEWED

Source sequence(s)

AC007421, AC087388

Consensus CDS

CCDS45605.1

UniProtKB/TrEMBL

A0A223PQI5

Related

ENSP00000398846.2, ENST00000455263.6

Conserved Domains (2) summary

pfam00870
Location:95 → 289

P53; P53 DNA-binding domain

pfam08563
Location:5 → 28

P53_TAD; P53 transactivation motif
NM_001126114.3 → NP_001119586.1 cellular tumor antigen p53 isoform b

See identical proteins and their annotated locations for NP_001119586.1

Status: REVIEWED

Source sequence(s)

AC007421, AC087388

Consensus CDS

CCDS45606.1

UniProtKB/TrEMBL

J3KP33

Related

ENSP00000391127.2, ENST00000420246.6

Conserved Domains (2) summary

pfam00870
Location:95 → 289

P53; P53 DNA-binding domain

pfam08563
Location:5 → 28

P53_TAD; P53 transactivation motif
NM_001126115.2 → NP_001119587.1 cellular tumor antigen p53 isoform d

See identical proteins and their annotated locations for NP_001119587.1

Status: REVIEWED

Source sequence(s)

AC007421, AC087388

Consensus CDS

CCDS73966.1

UniProtKB/TrEMBL

E9PFT5

Related

ENSP00000481179.1, ENST00000504937.5

Conserved Domains (2) summary

pfam07710
Location:187 → 226

P53_tetramer; P53 tetramerization motif

cl14608
Location:1 → 157

P53; P53 DNA-binding domain
NM_001126116.2 → NP_001119588.1 cellular tumor antigen p53 isoform e

See identical proteins and their annotated locations for NP_001119588.1

Status: REVIEWED

Source sequence(s)

AC007421, AC087388

Consensus CDS

CCDS73968.1

UniProtKB/TrEMBL

E7ESS1

Related

ENSP00000478499.1, ENST00000510385.5

Conserved Domains (1) summary

cl14608
Location:1 → 157

P53; P53 DNA-binding domain
NM_001126117.2 → NP_001119589.1 cellular tumor antigen p53 isoform f

See identical proteins and their annotated locations for NP_001119589.1

Status: REVIEWED

Source sequence(s)

AC007421, AC087388

Consensus CDS

CCDS73967.1

UniProtKB/TrEMBL

E7ESS1

Related

ENSP00000484409.1, ENST00000504290.5

Conserved Domains (1) summary

cl14608
Location:1 → 157

P53; P53 DNA-binding domain
NM_001126118.2 → NP_001119590.1 cellular tumor antigen p53 isoform g

See identical proteins and their annotated locations for NP_001119590.1

Status: REVIEWED

Source sequence(s)

AC007421, AC087388

Consensus CDS

CCDS73969.1

UniProtKB/TrEMBL

H2EHT1, K7PPU4

Related

ENSP00000478219.1, ENST00000610292.4

Conserved Domains (2) summary

pfam00870
Location:56 → 250

P53; P53 DNA-binding domain

pfam07710
Location:280 → 319

P53_tetramer; P53 tetramerisation motif
NM_001276695.3 → NP_001263624.1 cellular tumor antigen p53 isoform h

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains an additional exon in the 3' coding region, resulting in an alternate 3' coding region and 3' UTR, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (h, also known as delta40p53gamma) results from translation initiation at the downstream start codon. It has a shorter N-terminus and a distinct C-terminus, compared to isoform a.

Source sequence(s)

AK223026, DA453049, DQ186649

Consensus CDS

CCDS73970.1

UniProtKB/TrEMBL

A0A223PQI5

Related

ENSP00000480868.1, ENST00000610538.4

Conserved Domains (1) summary

pfam00870
Location:56 → 250

P53; P53 DNA-binding domain
NM_001276696.3 → NP_001263625.1 cellular tumor antigen p53 isoform i

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an additional exon in the 3' region, resulting in an alternate 3' coding region and 3' UTR, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (i, also known as delta40p53beta) results from translation initiation at the downstream start codon. It has a shorter N-terminus and a distinct C-terminus, compared to isoform a.

Source sequence(s)

AK223026, DA453049, DQ186648, DQ186649

Consensus CDS

CCDS73971.1

UniProtKB/TrEMBL

J3KP33

Related

ENSP00000482222.1, ENST00000622645.4

Conserved Domains (1) summary

pfam00870
Location:56 → 250

P53; P53 DNA-binding domain
NM_001276697.3 → NP_001263626.1 cellular tumor antigen p53 isoform j

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate promoter and lacks multiple 5' exons, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (j, also known as delta160p53alpha) results from translation initiation at the downstream start codon. It has a shorter N-terminus, compared to isoform a. This variant is supported by data in PMID:16131611.

Source sequence(s)

AK223026, DQ186650

Consensus CDS

CCDS73963.1

UniProtKB/TrEMBL

A0A087X1Q1

Related

ENSP00000484375.1, ENST00000619186.4

Conserved Domains (2) summary

pfam07710
Location:160 → 199

P53_tetramer; P53 tetramerisation motif

cl14608
Location:1 → 130

P53; P53 DNA-binding domain
NM_001276698.3 → NP_001263627.1 cellular tumor antigen p53 isoform k

Status: REVIEWED

Description

Transcript Variant: This variant (6) uses an alternate promoter and lacks multiple 5' exons, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (k, also known as delta160p53beta) results from translation initiation at the downstream start codon. It has a shorter N-terminus and a distinct C-terminus, compared to isoform a. This variant is supported by data in PMID:16131611.

Source sequence(s)

AK223026, DQ186651

Consensus CDS

CCDS73965.1

UniProtKB/TrEMBL

A0A087WXZ1, E7ESS1

Related

ENSP00000481401.1, ENST00000618944.4

Conserved Domains (1) summary

cl14608
Location:1 → 130

P53; P53 DNA-binding domain
NM_001276699.3 → NP_001263628.1 cellular tumor antigen p53 isoform l

Status: REVIEWED

Description

Transcript Variant: This variant (7) uses an alternate promoter and lacks multiple 5' exons, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (l, also known as delta160p53gamma) results from translation initiation at the downstream start codon. It has a shorter N-terminus and a distinct C-terminus, compared to isoform a. This variant is supported by data in PMID:16131611.

Source sequence(s)

AK223026, DQ186652

Consensus CDS

CCDS73964.1

UniProtKB/TrEMBL

A0A087WT22, E7ESS1

Related

ENSP00000477531.1, ENST00000610623.4

Conserved Domains (1) summary

cl14608
Location:1 → 130

P53; P53 DNA-binding domain
NM_001276760.3 → NP_001263689.1 cellular tumor antigen p53 isoform g

See identical proteins and their annotated locations for NP_001263689.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (g, also known as delta40p53alpha or deltaNp53) results from translation initiation at the downstream start codon. It has a shorter N-terminus, compared to isoform a. Variants 1, 2, and 8 encode isoform g.

Source sequence(s)

AK223026, DA453049, X02469

Consensus CDS

CCDS73969.1

UniProtKB/TrEMBL

H2EHT1, K7PPU4

Related

ENSP00000481638.1, ENST00000620739.4

Conserved Domains (2) summary

pfam00870
Location:56 → 250

P53; P53 DNA-binding domain

pfam07710
Location:280 → 319

P53_tetramer; P53 tetramerisation motif
NM_001276761.3 → NP_001263690.1 cellular tumor antigen p53 isoform g

See identical proteins and their annotated locations for NP_001263690.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (g, also known as delta40p53alpha or deltaNp53) results from translation initiation at the downstream start codon. It has a shorter N-terminus, compared to isoform a. Variants 1, 2, and 8 encode isoform g.

Source sequence(s)

AB082923, AK223026, DA453049, X02469

Consensus CDS

CCDS73969.1

UniProtKB/TrEMBL

H2EHT1, K7PPU4

Related

ENSP00000482537.1, ENST00000619485.4

Conserved Domains (2) summary

pfam00870
Location:56 → 250

P53; P53 DNA-binding domain

pfam07710
Location:280 → 319

P53_tetramer; P53 tetramerisation motif
NM_001407262.1 → NP_001394191.1 cellular tumor antigen p53 isoform a

Status: REVIEWED

Source sequence(s)

AC007421, AC087388

UniProtKB/Swiss-Prot

P04637, Q15086, Q15087, Q15088, Q16535, Q16807, Q16808, Q16809, Q16810, Q16811, Q16848, Q2XN98, Q3LRW1, Q3LRW2, Q3LRW3, Q3LRW4, Q3LRW5, Q86UG1, Q8J016, Q99659, Q9BTM4, Q9HAQ8, Q9NP68, Q9NPJ2, Q9NZD0, Q9UBI2, Q9UQ61

UniProtKB/TrEMBL

K7PPA8

Related

ENSP00000426252.2, ENST00000503591.2
NM_001407263.1 → NP_001394192.1 cellular tumor antigen p53 isoform g

Status: REVIEWED

Source sequence(s)

AC007421, AC087388

UniProtKB/TrEMBL

H2EHT1
NM_001407264.1 → NP_001394193.1 cellular tumor antigen p53 isoform a

Status: REVIEWED

Source sequence(s)

AC007421, AC087388

UniProtKB/Swiss-Prot

P04637, Q15086, Q15087, Q15088, Q16535, Q16807, Q16808, Q16809, Q16810, Q16811, Q16848, Q2XN98, Q3LRW1, Q3LRW2, Q3LRW3, Q3LRW4, Q3LRW5, Q86UG1, Q8J016, Q99659, Q9BTM4, Q9HAQ8, Q9NP68, Q9NPJ2, Q9NZD0, Q9UBI2, Q9UQ61

UniProtKB/TrEMBL

K7PPA8
NM_001407265.1 → NP_001394194.1 cellular tumor antigen p53 isoform g

Status: REVIEWED

Source sequence(s)

AC007421, AC087388

UniProtKB/TrEMBL

H2EHT1
NM_001407266.1 → NP_001394195.1 cellular tumor antigen p53 isoform a

Status: REVIEWED

Source sequence(s)

AC007421, AC087388

UniProtKB/Swiss-Prot

P04637, Q15086, Q15087, Q15088, Q16535, Q16807, Q16808, Q16809, Q16810, Q16811, Q16848, Q2XN98, Q3LRW1, Q3LRW2, Q3LRW3, Q3LRW4, Q3LRW5, Q86UG1, Q8J016, Q99659, Q9BTM4, Q9HAQ8, Q9NP68, Q9NPJ2, Q9NZD0, Q9UBI2, Q9UQ61

UniProtKB/TrEMBL

K7PPA8

Related

ENSP00000424104.2, ENST00000508793.6
NM_001407267.1 → NP_001394196.1 cellular tumor antigen p53 isoform g

Status: REVIEWED

Source sequence(s)

AC007421, AC087388

UniProtKB/TrEMBL

H2EHT1
NM_001407268.1 → NP_001394197.1 cellular tumor antigen p53 isoform b

Status: REVIEWED

Source sequence(s)

AC007421, AC087388

Related

ENSP00000352610.4, ENST00000359597.8
NM_001407269.1 → NP_001394198.1 cellular tumor antigen p53 isoform i

Status: REVIEWED

Source sequence(s)

AC007421, AC087388
NM_001407270.1 → NP_001394199.1 cellular tumor antigen p53 isoform b

Status: REVIEWED

Source sequence(s)

AC007421, AC087388
NM_001407271.1 → NP_001394200.1 cellular tumor antigen p53 isoform i

Status: REVIEWED

Source sequence(s)

AC007421, AC087388