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Adult Acute Myeloid Leukemia

MedGen UID:
113092
•Concept ID:
C0220615
•
Neoplastic Process
Synonyms: Adult Acute Myeloblastic Leukemia; Adult Acute Myelogenous Leukemia; Adult Acute Non-Lymphoblastic Leukemia; Adult Acute NonLymphoblastic Leukemia; Adult AML; Adult ANLL

Definition

An acute myeloid leukemia occurring in adults. [from NCI]

Professional guidelines

PubMed

Clinical profile, cytogenetics and treatment outcomes of adult acute myeloid leukemia.
Namratha Udupa MS, Babu KG, Suresh Babu MC, Lakshmaiah KC, Lokanatha D, Jacob AL, Lokesh KN, Rajeev LK, Rudresh AH, Devi L
J Cancer Res Ther 2020 Jan-Mar;16(1):18-22. doi: 10.4103/jcrt.JCRT_1162_16. PMID: 32362604
Treatment of adult acute myeloid leukemia.
Järvenpää J, Itälä-Remes M, Kauko T, Salmenniemi U, Kauppila M, Putkonen M, Salmi T, Remes K
Duodecim 2016;132(16):1465-73. PMID: 29188934
Exploitation of natural killer cells for the treatment of acute leukemia.
Handgretinger R, Lang P, André MC
Blood 2016 Jun 30;127(26):3341-9. Epub 2016 May 20 doi: 10.1182/blood-2015-12-629055. PMID: 27207791

Recent clinical studies

Etiology

Acute myeloid leukemias with UBTF tandem duplications are sensitive to menin inhibitors.
Barajas JM, Rasouli M, Umeda M, Hiltenbrand R, Abdelhamed S, Mohnani R, Arthur B, Westover T, Thomas ME 3rd, Ashtiani M, Janke LJ, Xu B, Chang TC, Rosikiewicz W, Xiong E, Rolle C, Low J, Krishan R, Song G, Walsh MP, Ma J, Rubnitz JE, Iacobucci I, Chen T, Krippner-Heidenreich A, Zwaan CM, Heidenreich O, Klco JM
Blood 2024 Feb 15;143(7):619-630. doi: 10.1182/blood.2023021359. PMID: 37890156Free PMC Article
How I diagnose and treat NPM1-mutated AML.
Falini B, Brunetti L, Martelli MP
Blood 2021 Feb 4;137(5):589-599. doi: 10.1182/blood.2020008211. PMID: 33171486
NPM1-mutated acute myeloid leukemia: from bench to bedside.
Falini B, Brunetti L, Sportoletti P, Martelli MP
Blood 2020 Oct 8;136(15):1707-1721. doi: 10.1182/blood.2019004226. PMID: 32609823
Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia.
Metzeler KH, Herold T, Rothenberg-Thurley M, Amler S, Sauerland MC, Görlich D, Schneider S, Konstandin NP, Dufour A, Bräundl K, Ksienzyk B, Zellmeier E, Hartmann L, Greif PA, Fiegl M, Subklewe M, Bohlander SK, Krug U, Faldum A, Berdel WE, Wörmann B, Büchner T, Hiddemann W, Braess J, Spiekermann K; AMLCG Study Group
Blood 2016 Aug 4;128(5):686-98. Epub 2016 Jun 10 doi: 10.1182/blood-2016-01-693879. PMID: 27288520
Randomized study of induction therapy comparing standard-dose idarubicin with high-dose daunorubicin in adult patients with previously untreated acute myeloid leukemia: the JALSG AML201 Study.
Ohtake S, Miyawaki S, Fujita H, Kiyoi H, Shinagawa K, Usui N, Okumura H, Miyamura K, Nakaseko C, Miyazaki Y, Fujieda A, Nagai T, Yamane T, Taniwaki M, Takahashi M, Yagasaki F, Kimura Y, Asou N, Sakamaki H, Handa H, Honda S, Ohnishi K, Naoe T, Ohno R
Blood 2011 Feb 24;117(8):2358-65. Epub 2010 Aug 6 doi: 10.1182/blood-2010-03-273243. PMID: 20693429

Diagnosis

Acute myeloid leukemias with UBTF tandem duplications are sensitive to menin inhibitors.
Barajas JM, Rasouli M, Umeda M, Hiltenbrand R, Abdelhamed S, Mohnani R, Arthur B, Westover T, Thomas ME 3rd, Ashtiani M, Janke LJ, Xu B, Chang TC, Rosikiewicz W, Xiong E, Rolle C, Low J, Krishan R, Song G, Walsh MP, Ma J, Rubnitz JE, Iacobucci I, Chen T, Krippner-Heidenreich A, Zwaan CM, Heidenreich O, Klco JM
Blood 2024 Feb 15;143(7):619-630. doi: 10.1182/blood.2023021359. PMID: 37890156Free PMC Article
How I diagnose and treat NPM1-mutated AML.
Falini B, Brunetti L, Martelli MP
Blood 2021 Feb 4;137(5):589-599. doi: 10.1182/blood.2020008211. PMID: 33171486
NPM1-mutated acute myeloid leukemia: from bench to bedside.
Falini B, Brunetti L, Sportoletti P, Martelli MP
Blood 2020 Oct 8;136(15):1707-1721. doi: 10.1182/blood.2019004226. PMID: 32609823
Venetoclax-based therapies for acute myeloid leukemia.
Guerra VA, DiNardo C, Konopleva M
Best Pract Res Clin Haematol 2019 Jun;32(2):145-153. Epub 2019 May 24 doi: 10.1016/j.beha.2019.05.008. PMID: 31203996Free PMC Article
Randomized study of induction therapy comparing standard-dose idarubicin with high-dose daunorubicin in adult patients with previously untreated acute myeloid leukemia: the JALSG AML201 Study.
Ohtake S, Miyawaki S, Fujita H, Kiyoi H, Shinagawa K, Usui N, Okumura H, Miyamura K, Nakaseko C, Miyazaki Y, Fujieda A, Nagai T, Yamane T, Taniwaki M, Takahashi M, Yagasaki F, Kimura Y, Asou N, Sakamaki H, Handa H, Honda S, Ohnishi K, Naoe T, Ohno R
Blood 2011 Feb 24;117(8):2358-65. Epub 2010 Aug 6 doi: 10.1182/blood-2010-03-273243. PMID: 20693429

Therapy

Venetoclax in adult acute myeloid leukemia.
Hu M, Li W, Zhang Y, Liang C, Tan J, Wang Y
Biomed Pharmacother 2023 Dec;168:115820. Epub 2023 Nov 6 doi: 10.1016/j.biopha.2023.115820. PMID: 37925935
How I diagnose and treat NPM1-mutated AML.
Falini B, Brunetti L, Martelli MP
Blood 2021 Feb 4;137(5):589-599. doi: 10.1182/blood.2020008211. PMID: 33171486
Venetoclax-based therapies for acute myeloid leukemia.
Guerra VA, DiNardo C, Konopleva M
Best Pract Res Clin Haematol 2019 Jun;32(2):145-153. Epub 2019 May 24 doi: 10.1016/j.beha.2019.05.008. PMID: 31203996Free PMC Article
Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia.
Metzeler KH, Herold T, Rothenberg-Thurley M, Amler S, Sauerland MC, Görlich D, Schneider S, Konstandin NP, Dufour A, Bräundl K, Ksienzyk B, Zellmeier E, Hartmann L, Greif PA, Fiegl M, Subklewe M, Bohlander SK, Krug U, Faldum A, Berdel WE, Wörmann B, Büchner T, Hiddemann W, Braess J, Spiekermann K; AMLCG Study Group
Blood 2016 Aug 4;128(5):686-98. Epub 2016 Jun 10 doi: 10.1182/blood-2016-01-693879. PMID: 27288520
Randomized study of induction therapy comparing standard-dose idarubicin with high-dose daunorubicin in adult patients with previously untreated acute myeloid leukemia: the JALSG AML201 Study.
Ohtake S, Miyawaki S, Fujita H, Kiyoi H, Shinagawa K, Usui N, Okumura H, Miyamura K, Nakaseko C, Miyazaki Y, Fujieda A, Nagai T, Yamane T, Taniwaki M, Takahashi M, Yagasaki F, Kimura Y, Asou N, Sakamaki H, Handa H, Honda S, Ohnishi K, Naoe T, Ohno R
Blood 2011 Feb 24;117(8):2358-65. Epub 2010 Aug 6 doi: 10.1182/blood-2010-03-273243. PMID: 20693429

Prognosis

Venetoclax in adult acute myeloid leukemia.
Hu M, Li W, Zhang Y, Liang C, Tan J, Wang Y
Biomed Pharmacother 2023 Dec;168:115820. Epub 2023 Nov 6 doi: 10.1016/j.biopha.2023.115820. PMID: 37925935
Therapeutic implications of menin inhibition in acute leukemias.
Issa GC, Ravandi F, DiNardo CD, Jabbour E, Kantarjian HM, Andreeff M
Leukemia 2021 Sep;35(9):2482-2495. Epub 2021 Jun 15 doi: 10.1038/s41375-021-01309-y. PMID: 34131281
NPM1-mutated acute myeloid leukemia: from bench to bedside.
Falini B, Brunetti L, Sportoletti P, Martelli MP
Blood 2020 Oct 8;136(15):1707-1721. doi: 10.1182/blood.2019004226. PMID: 32609823
Venetoclax-based therapies for acute myeloid leukemia.
Guerra VA, DiNardo C, Konopleva M
Best Pract Res Clin Haematol 2019 Jun;32(2):145-153. Epub 2019 May 24 doi: 10.1016/j.beha.2019.05.008. PMID: 31203996Free PMC Article
Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia.
Metzeler KH, Herold T, Rothenberg-Thurley M, Amler S, Sauerland MC, Görlich D, Schneider S, Konstandin NP, Dufour A, Bräundl K, Ksienzyk B, Zellmeier E, Hartmann L, Greif PA, Fiegl M, Subklewe M, Bohlander SK, Krug U, Faldum A, Berdel WE, Wörmann B, Büchner T, Hiddemann W, Braess J, Spiekermann K; AMLCG Study Group
Blood 2016 Aug 4;128(5):686-98. Epub 2016 Jun 10 doi: 10.1182/blood-2016-01-693879. PMID: 27288520

Clinical prediction guides

DELE1 haploinsufficiency causes resistance to mitochondrial stress-induced apoptosis in monosomy 5/del(5q) AML.
Spinella JF, Chagraoui J, Moison C, Lavallée VP, Boivin I, Gracias D, Lavallée S, Carpentier GR, Beliveau F, Hébert J, Sauvageau G
Leukemia 2024 Mar;38(3):530-537. Epub 2023 Dec 15 doi: 10.1038/s41375-023-02107-4. PMID: 38102204Free PMC Article
Venetoclax in adult acute myeloid leukemia.
Hu M, Li W, Zhang Y, Liang C, Tan J, Wang Y
Biomed Pharmacother 2023 Dec;168:115820. Epub 2023 Nov 6 doi: 10.1016/j.biopha.2023.115820. PMID: 37925935
Therapeutic implications of menin inhibition in acute leukemias.
Issa GC, Ravandi F, DiNardo CD, Jabbour E, Kantarjian HM, Andreeff M
Leukemia 2021 Sep;35(9):2482-2495. Epub 2021 Jun 15 doi: 10.1038/s41375-021-01309-y. PMID: 34131281
TBC1D16 predicts chemosensitivity and prognosis in adult acute myeloid leukemia (AML) patients.
Liu H, Chen P, Yang YL, Zhu KW, Wang T, Tang L, Liu YL, Cao S, Zhou G, Zeng H, Zhao XL, Zhang W, Chen XP
Eur J Pharmacol 2021 Mar 15;895:173894. Epub 2021 Jan 19 doi: 10.1016/j.ejphar.2021.173894. PMID: 33476656
Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia.
Metzeler KH, Herold T, Rothenberg-Thurley M, Amler S, Sauerland MC, Görlich D, Schneider S, Konstandin NP, Dufour A, Bräundl K, Ksienzyk B, Zellmeier E, Hartmann L, Greif PA, Fiegl M, Subklewe M, Bohlander SK, Krug U, Faldum A, Berdel WE, Wörmann B, Büchner T, Hiddemann W, Braess J, Spiekermann K; AMLCG Study Group
Blood 2016 Aug 4;128(5):686-98. Epub 2016 Jun 10 doi: 10.1182/blood-2016-01-693879. PMID: 27288520

Recent systematic reviews

Systematic review and meta-analysis evaluating clinical outcomes in adult acute myeloid leukemia patients with central nervous system involvement.
Goulart H, Sastow D, Moshier E, Martin L, Mascarenhas J, Tremblay D
Leuk Res 2024 Feb;137:107452. Epub 2024 Feb 6 doi: 10.1016/j.leukres.2024.107452. PMID: 38335816
Comparison of early mortality between leukapheresis and non-leukapheresis in adult acute myeloid leukemia patients with hyperleukocytosis: a systematic review and meta-analysis.
Rinaldi I, Sutandyo N, Winston K
Hematology 2022 Dec;27(1):141-149. doi: 10.1080/16078454.2021.2024939. PMID: 35068391
Efficacy and safety of adding gemtuzumab ozogamicin to conventional chemotherapy for adult acute myeloid leukemia: a systematic review and meta-analysis.
Guo Y, Deng L, Qiao Y, Liu B
Hematology 2022 Dec;27(1):53-64. doi: 10.1080/16078454.2021.2013410. PMID: 34957930
Hematopoietic Cell Transplantation in the Treatment of Newly Diagnosed Adult Acute Myeloid Leukemia: An Evidence-Based Review from the American Society of Transplantation and Cellular Therapy.
Dholaria B, Savani BN, Hamilton BK, Oran B, Liu HD, Tallman MS, Ciurea SO, Holtzman NG, Ii GLP, Devine SM, Mannis G, Grunwald MR, Appelbaum F, Rodriguez C, El Chaer F, Shah N, Hashmi SK, Kharfan-Dabaja MA, DeFilipp Z, Aljurf M, AlShaibani A, Inamoto Y, Jain T, Majhail N, Perales MA, Mohty M, Hamadani M, Carpenter PA, Nagler A
Transplant Cell Ther 2021 Jan;27(1):6-20. Epub 2020 Sep 20 doi: 10.1016/j.bbmt.2020.09.020. PMID: 32966881
Efficacy and Toxicity of Idarubicin Versus High-dose Daunorubicin for Induction Chemotherapy in Adult Acute Myeloid Leukemia: A Systematic Review and Meta-analysis.
Owattanapanich W, Owattanapanich N, Kungwankiattichai S, Ungprasert P, Ruchutrakool T
Clin Lymphoma Myeloma Leuk 2018 Dec;18(12):814-821.e3. Epub 2018 Aug 22 doi: 10.1016/j.clml.2018.08.008. PMID: 30241991

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