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Brain infarction

MedGen UID:
148426
Concept ID:
C0751955
Disease or Syndrome
Synonyms: Brain Infarct; Brain Infarction; Brain Infarctions; Brain Infarcts; Infarct, Brain; Infarction, Brain; Infarctions, Brain; Infarcts, Brain
 
Monarch Initiative: MONDO:0005394

Definition

Tissue necrosis in any area of the brain, including the cerebral hemispheres, the cerebellum, and the brain stem. Brain infarction is the result of a cascade of events initiated by inadequate blood flow through the brain that is followed by hypoxia and hypoglycemia in brain tissue. Damage may be temporary, permanent, selective or pan-necrosis. [from MONDO]

Professional guidelines

PubMed

Meinel TR, Triulzi CB, Kaesmacher J, Mujanovic A, Pasi M, Leung LY, Kent DM, Sui Y, Seiffge D, Bücke P, Umarova R, Arnold M, Roten L, Nguyen TN, Wardlaw J, Fischer U
Eur Stroke J 2023 Dec;8(4):1079-1088. Epub 2023 Jul 10 doi: 10.1177/23969873231187444. PMID: 37427426Free PMC Article
Thimukonda Jegadeesan J, Baldia M, Basu B
Acta Biomater 2022 Dec;154:63-82. Epub 2022 Oct 19 doi: 10.1016/j.actbio.2022.10.030. PMID: 36272686
O'Shea TM
Clin Obstet Gynecol 2008 Dec;51(4):816-28. doi: 10.1097/GRF.0b013e3181870ba7. PMID: 18981805Free PMC Article

Recent clinical studies

Etiology

Gerstenecker A, Norling AM, Jacob A, Lazar RM
Neuropsychol Rev 2023 Jun;33(2):474-491. Epub 2022 Jul 8 doi: 10.1007/s11065-022-09548-1. PMID: 35804216
Gonçalves B, Turon R, Mendes A, Melo N, Lacerda P, Brasil P, Bozza FA, Kurtz P, Righy C
World Neurosurg 2018 Jul;115:e292-e298. Epub 2018 Apr 13 doi: 10.1016/j.wneu.2018.04.037. PMID: 29660554
Moroni F, Ammirati E, Magnoni M, D'Ascenzo F, Anselmino M, Anzalone N, Rocca MA, Falini A, Filippi M, Camici PG
Int J Cardiol 2016 Nov 15;223:681-687. Epub 2016 Aug 13 doi: 10.1016/j.ijcard.2016.08.234. PMID: 27568989
Gupta A, Giambrone AE, Gialdini G, Finn C, Delgado D, Gutierrez J, Wright C, Beiser AS, Seshadri S, Pandya A, Kamel H
Stroke 2016 Mar;47(3):719-25. doi: 10.1161/STROKEAHA.115.011889. PMID: 26888534Free PMC Article
Lastilla M
Clin Exp Hypertens 2006 Apr-May;28(3-4):205-15. doi: 10.1080/10641960600549082. PMID: 16833026

Diagnosis

Welgampola MS, Young AS, Pogson JM, Bradshaw AP, Halmagyi GM
Pract Neurol 2019 Dec;19(6):492-501. Epub 2019 Jul 20 doi: 10.1136/practneurol-2019-002199. PMID: 31326945
Scharf EL, Cloft HJ, Wijdicks E
Neurocrit Care 2016 Apr;24(2):268-72. doi: 10.1007/s12028-015-0186-x. PMID: 26227632
Mangla R, Kolar B, Almast J, Ekholm SE
Radiographics 2011 Sep-Oct;31(5):1201-14. doi: 10.1148/rg.315105014. PMID: 21918038
Lastilla M
Clin Exp Hypertens 2006 Apr-May;28(3-4):205-15. doi: 10.1080/10641960600549082. PMID: 16833026
MILLIKAN C, KETY SS, FISHER CM, PAGE IH, SAHS A, ROSE AS
Neurology 1956 Aug;6(8):580-93. doi: 10.1212/wnl.6.8.580. PMID: 13348821

Therapy

Mistry EA, Hart KW, Davis LT, Gao Y, Prestigiacomo CJ, Mittal S, Mehta T, LaFever H, Harker P, Wilson-Perez HE, Beasley KA, Krothapalli N, Lippincott E, Stefek H, Froehler M, Chitale R, Fusco M, Grossman A, Shirani P, Smith M, Jaffa MN, Yeatts SD, Albers GW, Wanderer JP, Tolles J, Lindsell CJ, Lewis RJ, Bernard GR, Khatri P
JAMA 2023 Sep 5;330(9):821-831. doi: 10.1001/jama.2023.14330. PMID: 37668620Free PMC Article
Søndergaard L, Kasner SE, Rhodes JF, Andersen G, Iversen HK, Nielsen-Kudsk JE, Settergren M, Sjöstrand C, Roine RO, Hildick-Smith D, Spence JD, Thomassen L; Gore REDUCE Clinical Study Investigators
N Engl J Med 2017 Sep 14;377(11):1033-1042. doi: 10.1056/NEJMoa1707404. PMID: 28902580
Nidorf SM, Eikelboom JW, Budgeon CA, Thompson PL
J Am Coll Cardiol 2013 Jan 29;61(4):404-410. Epub 2012 Dec 19 doi: 10.1016/j.jacc.2012.10.027. PMID: 23265346
Chabriat H, Joutel A, Dichgans M, Tournier-Lasserve E, Bousser MG
Lancet Neurol 2009 Jul;8(7):643-53. doi: 10.1016/S1474-4422(09)70127-9. PMID: 19539236
Tabrizchi R
Curr Opin Investig Drugs 2000 Nov;1(3):347-54. PMID: 11249718

Prognosis

Schattner A
Am J Med 2022 Jan;135(1):12-14. Epub 2021 Sep 8 doi: 10.1016/j.amjmed.2021.07.044. PMID: 34508701
Gonçalves B, Turon R, Mendes A, Melo N, Lacerda P, Brasil P, Bozza FA, Kurtz P, Righy C
World Neurosurg 2018 Jul;115:e292-e298. Epub 2018 Apr 13 doi: 10.1016/j.wneu.2018.04.037. PMID: 29660554
Nidorf SM, Eikelboom JW, Budgeon CA, Thompson PL
J Am Coll Cardiol 2013 Jan 29;61(4):404-410. Epub 2012 Dec 19 doi: 10.1016/j.jacc.2012.10.027. PMID: 23265346
Jović-Stosić J, Babić G, Todorović V
Vojnosanit Pregl 2009 Jun;66(6):477-81. doi: 10.2298/vsp0906477j. PMID: 19583147
Lastilla M
Clin Exp Hypertens 2006 Apr-May;28(3-4):205-15. doi: 10.1080/10641960600549082. PMID: 16833026

Clinical prediction guides

Andel PM, Aamodt AH, Gleditsch J, Melin E, Rootwelt-Revheim ME, Steine K, Atar D
Cardiology 2024;149(6):571-579. Epub 2024 Aug 1 doi: 10.1159/000540007. PMID: 39025051Free PMC Article
Costalat V, Jovin TG, Albucher JF, Cognard C, Henon H, Nouri N, Gory B, Richard S, Marnat G, Sibon I, Di Maria F, Annan M, Boulouis G, Cardona P, Obadia M, Piotin M, Bourcier R, Guillon B, Godard S, Pasco-Papon A, Eker OF, Cho TH, Turc G, Naggara O, Velasco S, Lamy M, Clarençon F, Alamowitch S, Renu A, Suissa L, Brunel H, Gentric JC, Timsit S, Lamy C, Chivot C, Macian-Montoro F, Mounayer C, Ozkul-Wermester O, Papagiannaki C, Wolff V, Pop R, Ferrier A, Chabert E, Ricolfi F, Béjot Y, Lopez-Cancio E, Vega P, Spelle L, Denier C, Millán M, Arenillas JF, Mazighi M, Houdart E, Del Mar Freijo M, Duhamel A, Sanossian N, Liebeskind DS, Labreuche J, Lapergue B, Arquizan C; LASTE Trial Investigators
N Engl J Med 2024 May 9;390(18):1677-1689. doi: 10.1056/NEJMoa2314063. PMID: 38718358
Mistry EA, Hart KW, Davis LT, Gao Y, Prestigiacomo CJ, Mittal S, Mehta T, LaFever H, Harker P, Wilson-Perez HE, Beasley KA, Krothapalli N, Lippincott E, Stefek H, Froehler M, Chitale R, Fusco M, Grossman A, Shirani P, Smith M, Jaffa MN, Yeatts SD, Albers GW, Wanderer JP, Tolles J, Lindsell CJ, Lewis RJ, Bernard GR, Khatri P
JAMA 2023 Sep 5;330(9):821-831. doi: 10.1001/jama.2023.14330. PMID: 37668620Free PMC Article
Chaturvedi S, Yu J, Brown J, Wei A, Selvakumar S, Gerber GF, Moliterno AR, Streiff MB, Kraus P, Logue CM, Yui JC, Naik RP, Latif H, Lanzkron SM, Braunstein EM, Brodsky RA, Gottesman RF, Lin DD
Blood 2023 Jul 27;142(4):325-335. doi: 10.1182/blood.2023019663. PMID: 37216688Free PMC Article
Hahne K, Mönnig G, Samol A
Vasc Health Risk Manag 2016;12:65-74. Epub 2016 Mar 7 doi: 10.2147/VHRM.S81807. PMID: 27022272Free PMC Article

Recent systematic reviews

Gerstenecker A, Norling AM, Jacob A, Lazar RM
Neuropsychol Rev 2023 Jun;33(2):474-491. Epub 2022 Jul 8 doi: 10.1007/s11065-022-09548-1. PMID: 35804216
Debette S, Schilling S, Duperron MG, Larsson SC, Markus HS
JAMA Neurol 2019 Jan 1;76(1):81-94. doi: 10.1001/jamaneurol.2018.3122. PMID: 30422209Free PMC Article
Gonçalves B, Turon R, Mendes A, Melo N, Lacerda P, Brasil P, Bozza FA, Kurtz P, Righy C
World Neurosurg 2018 Jul;115:e292-e298. Epub 2018 Apr 13 doi: 10.1016/j.wneu.2018.04.037. PMID: 29660554
Gupta A, Giambrone AE, Gialdini G, Finn C, Delgado D, Gutierrez J, Wright C, Beiser AS, Seshadri S, Pandya A, Kamel H
Stroke 2016 Mar;47(3):719-25. doi: 10.1161/STROKEAHA.115.011889. PMID: 26888534Free PMC Article
Prabhakaran S, Ruff I, Bernstein RA
JAMA 2015 Apr 14;313(14):1451-62. doi: 10.1001/jama.2015.3058. PMID: 25871671

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