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Vulvar disease

MedGen UID:
53055
•Concept ID:
C0042994
•
Disease or Syndrome
Synonyms: Disease, Vulvar; Diseases, Vulvar; Vulvar Disease; Vulvar Diseases
SNOMED CT: Disorder of vulva (5089007); Vulvar disorder (5089007); Vulval disorder (5089007)
 
Monarch Initiative: MONDO:0002187

Definition

A non-neoplastic or neoplastic disorder that affects the vulva. Representative examples include infection, Bartholin gland adenoma, and vulvar carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVulvar disease

Professional guidelines

PubMed

European Society of Gynaecological Oncology Guidelines for the Management of Patients with Vulvar Cancer - Update 2023.
Oonk MHM, Planchamp F, Baldwin P, Mahner S, Mirza MR, Fischerová D, Creutzberg CL, Guillot E, Garganese G, Lax S, Redondo A, Sturdza A, Taylor A, Ulrikh E, Vandecaveye V, van der Zee A, Wölber L, Zach D, Zannoni GF, Zapardiel I
Int J Gynecol Cancer 2023 Jul 3;33(7):1023-1043. doi: 10.1136/ijgc-2023-004486. PMID: 37369376Free PMC Article
Evaluation and Management of Vulvar Disease.
Venkatesan A
Obstet Gynecol Clin North Am 2017 Sep;44(3):xiii-xiv. doi: 10.1016/j.ogc.2017.06.001. PMID: 28778648
Diagnosis and management of vulvar ulcers.
Bandow GD
Dermatol Clin 2010 Oct;28(4):753-63. doi: 10.1016/j.det.2010.08.008. PMID: 20883918

Recent clinical studies

Etiology

Inflammatory Vulvar Dermatoses (Part I).
Sanchez I, Raffi J, Kraus CN
Urology 2022 Jul;165:23-30. Epub 2022 Apr 10 doi: 10.1016/j.urology.2022.03.025. PMID: 35413374
Vulvar Neoplasms (Part II).
Sanchez I, Raffi J, Kraus CN
Urology 2022 Jul;165:31-35. Epub 2022 Feb 23 doi: 10.1016/j.urology.2022.02.007. PMID: 35218865
Final efficacy, immunogenicity, and safety analyses of a nine-valent human papillomavirus vaccine in women aged 16-26 years: a randomised, double-blind trial.
Huh WK, Joura EA, Giuliano AR, Iversen OE, de Andrade RP, Ault KA, Bartholomew D, Cestero RM, Fedrizzi EN, Hirschberg AL, Mayrand MH, Ruiz-Sternberg AM, Stapleton JT, Wiley DJ, Ferenczy A, Kurman R, Ronnett BM, Stoler MH, Cuzick J, Garland SM, Kjaer SK, Bautista OM, Haupt R, Moeller E, Ritter M, Roberts CC, Shields C, Luxembourg A
Lancet 2017 Nov 11;390(10108):2143-2159. Epub 2017 Sep 5 doi: 10.1016/S0140-6736(17)31821-4. PMID: 28886907
Effect of the human papillomavirus (HPV) quadrivalent vaccine in a subgroup of women with cervical and vulvar disease: retrospective pooled analysis of trial data.
Joura EA, Garland SM, Paavonen J, Ferris DG, Perez G, Ault KA, Huh WK, Sings HL, James MK, Haupt RM; FUTURE I and II Study Group
BMJ 2012 Mar 27;344:e1401. doi: 10.1136/bmj.e1401. PMID: 22454089Free PMC Article
Vulvar disease.
Foster DC
Obstet Gynecol 2002 Jul;100(1):145-63. doi: 10.1016/s0029-7844(02)02080-x. PMID: 12100817

Diagnosis

Vulvar Neoplasms (Part II).
Sanchez I, Raffi J, Kraus CN
Urology 2022 Jul;165:31-35. Epub 2022 Feb 23 doi: 10.1016/j.urology.2022.02.007. PMID: 35218865
Evaluation and Management of Vulvar Disease.
Venkatesan A
Obstet Gynecol Clin North Am 2017 Sep;44(3):xiii-xiv. doi: 10.1016/j.ogc.2017.06.001. PMID: 28778648
Paediatric vulvar disease.
Simpson RC, Murphy R
Best Pract Res Clin Obstet Gynaecol 2014 Oct;28(7):1028-41. Epub 2014 Jul 17 doi: 10.1016/j.bpobgyn.2014.07.004. PMID: 25134451
Effect of the human papillomavirus (HPV) quadrivalent vaccine in a subgroup of women with cervical and vulvar disease: retrospective pooled analysis of trial data.
Joura EA, Garland SM, Paavonen J, Ferris DG, Perez G, Ault KA, Huh WK, Sings HL, James MK, Haupt RM; FUTURE I and II Study Group
BMJ 2012 Mar 27;344:e1401. doi: 10.1136/bmj.e1401. PMID: 22454089Free PMC Article
Vulvar disease.
Foster DC
Obstet Gynecol 2002 Jul;100(1):145-63. doi: 10.1016/s0029-7844(02)02080-x. PMID: 12100817

Therapy

A successful management algorithm for vulvar abscess: A tertiary hospital experience.
Aksakal SE, Altınbas SK, Ozkan MA, Kayikcioglu F, Tapisiz OL
J Obstet Gynaecol Res 2022 Nov;48(11):2935-2945. Epub 2022 Jul 30 doi: 10.1111/jog.15373. PMID: 35908182
Efficacy and tolerance of photodynamic therapy for vulvar Paget's disease: a multicentric retrospective study.
Rioli DI, Samimi M, Beneton N, Hainaut E, Martin L, Misery L, Quereux G
Eur J Dermatol 2018 Jun 1;28(3):351-355. doi: 10.1684/ejd.2018.3289. PMID: 29976540
Final efficacy, immunogenicity, and safety analyses of a nine-valent human papillomavirus vaccine in women aged 16-26 years: a randomised, double-blind trial.
Huh WK, Joura EA, Giuliano AR, Iversen OE, de Andrade RP, Ault KA, Bartholomew D, Cestero RM, Fedrizzi EN, Hirschberg AL, Mayrand MH, Ruiz-Sternberg AM, Stapleton JT, Wiley DJ, Ferenczy A, Kurman R, Ronnett BM, Stoler MH, Cuzick J, Garland SM, Kjaer SK, Bautista OM, Haupt R, Moeller E, Ritter M, Roberts CC, Shields C, Luxembourg A
Lancet 2017 Nov 11;390(10108):2143-2159. Epub 2017 Sep 5 doi: 10.1016/S0140-6736(17)31821-4. PMID: 28886907
Effect of the human papillomavirus (HPV) quadrivalent vaccine in a subgroup of women with cervical and vulvar disease: retrospective pooled analysis of trial data.
Joura EA, Garland SM, Paavonen J, Ferris DG, Perez G, Ault KA, Huh WK, Sings HL, James MK, Haupt RM; FUTURE I and II Study Group
BMJ 2012 Mar 27;344:e1401. doi: 10.1136/bmj.e1401. PMID: 22454089Free PMC Article
Sentinel node dissection is safe in the treatment of early-stage vulvar cancer.
Van der Zee AG, Oonk MH, De Hullu JA, Ansink AC, Vergote I, Verheijen RH, Maggioni A, Gaarenstroom KN, Baldwin PJ, Van Dorst EB, Van der Velden J, Hermans RH, van der Putten H, Drouin P, Schneider A, Sluiter WJ
J Clin Oncol 2008 Feb 20;26(6):884-9. doi: 10.1200/JCO.2007.14.0566. PMID: 18281661

Prognosis

Final efficacy, immunogenicity, and safety analyses of a nine-valent human papillomavirus vaccine in women aged 16-26 years: a randomised, double-blind trial.
Huh WK, Joura EA, Giuliano AR, Iversen OE, de Andrade RP, Ault KA, Bartholomew D, Cestero RM, Fedrizzi EN, Hirschberg AL, Mayrand MH, Ruiz-Sternberg AM, Stapleton JT, Wiley DJ, Ferenczy A, Kurman R, Ronnett BM, Stoler MH, Cuzick J, Garland SM, Kjaer SK, Bautista OM, Haupt R, Moeller E, Ritter M, Roberts CC, Shields C, Luxembourg A
Lancet 2017 Nov 11;390(10108):2143-2159. Epub 2017 Sep 5 doi: 10.1016/S0140-6736(17)31821-4. PMID: 28886907
Vulvar cancer: a review for dermatologists.
Chokoeva AA, Tchernev G, Castelli E, Orlando E, Verma SB, Grebe M, Wollina U
Wien Med Wochenschr 2015 Apr;165(7-8):164-77. Epub 2015 May 1 doi: 10.1007/s10354-015-0354-9. PMID: 25930015
Effect of the human papillomavirus (HPV) quadrivalent vaccine in a subgroup of women with cervical and vulvar disease: retrospective pooled analysis of trial data.
Joura EA, Garland SM, Paavonen J, Ferris DG, Perez G, Ault KA, Huh WK, Sings HL, James MK, Haupt RM; FUTURE I and II Study Group
BMJ 2012 Mar 27;344:e1401. doi: 10.1136/bmj.e1401. PMID: 22454089Free PMC Article
Sentinel node dissection is safe in the treatment of early-stage vulvar cancer.
Van der Zee AG, Oonk MH, De Hullu JA, Ansink AC, Vergote I, Verheijen RH, Maggioni A, Gaarenstroom KN, Baldwin PJ, Van Dorst EB, Van der Velden J, Hermans RH, van der Putten H, Drouin P, Schneider A, Sluiter WJ
J Clin Oncol 2008 Feb 20;26(6):884-9. doi: 10.1200/JCO.2007.14.0566. PMID: 18281661
Vulvar disease.
Foster DC
Obstet Gynecol 2002 Jul;100(1):145-63. doi: 10.1016/s0029-7844(02)02080-x. PMID: 12100817

Clinical prediction guides

Outcomes and prognostic factors of surgically treated extramammary Paget's disease of the vulva.
Cho A, Kim DY, Suh DS, Kim JH, Kim YM, Kim YT, Park JY
J Gynecol Oncol 2023 Nov;34(6):e76. Epub 2023 Jul 5 doi: 10.3802/jgo.2023.34.e76. PMID: 37477099Free PMC Article
High-Yield Vulvar Histopathology for the Clinician.
Reutter JC
Obstet Gynecol Clin North Am 2017 Sep;44(3):329-338. doi: 10.1016/j.ogc.2017.05.001. PMID: 28778634
Vulvar psoriasis in adults and children: a clinical audit of 194 cases and review of the literature.
Kapila S, Bradford J, Fischer G
J Low Genit Tract Dis 2012 Oct;16(4):364-71. doi: 10.1097/LGT.0b013e31824b9e5e. PMID: 22968059
Considerations for disease impact and outcome measures in vulvar disease.
Simpson RC, Murphy R
J Low Genit Tract Dis 2012 Oct;16(4):460-3. doi: 10.1097/LGT.0b013e3182449bc1. PMID: 22659774
Sentinel node dissection is safe in the treatment of early-stage vulvar cancer.
Van der Zee AG, Oonk MH, De Hullu JA, Ansink AC, Vergote I, Verheijen RH, Maggioni A, Gaarenstroom KN, Baldwin PJ, Van Dorst EB, Van der Velden J, Hermans RH, van der Putten H, Drouin P, Schneider A, Sluiter WJ
J Clin Oncol 2008 Feb 20;26(6):884-9. doi: 10.1200/JCO.2007.14.0566. PMID: 18281661

Recent systematic reviews

A systematic review of laser therapy for vulvar skin conditions.
Kim K, Desai M, Elsensohn A, Kraus CN
J Am Acad Dermatol 2023 May;88(5):1200-1201. Epub 2023 Jan 11 doi: 10.1016/j.jaad.2023.01.003. PMID: 36639033
Sex differences in initial treatment for genital extramammary Paget disease in the United States: A systematic review.
Rastogi S, Thiede R, Sadowsky LM, Hua T, Rastogi A, Miller C, Schlosser BJ
J Am Acad Dermatol 2023 Mar;88(3):577-586. Epub 2019 Apr 20 doi: 10.1016/j.jaad.2019.04.046. PMID: 31015011
Basal cell carcinoma of the vulva: a case report and systematic review of the literature.
Renati S, Henderson C, Aluko A, Burgin S
Int J Dermatol 2019 Aug;58(8):892-902. Epub 2018 Dec 2 doi: 10.1111/ijd.14307. PMID: 30506682
Vulvar involvement in pediatric Crohn's disease: a systematic review.
Granese R, Calagna G, Morabito G, Carriero C, Perino A, Tonni G, Romano C
Arch Gynecol Obstet 2018 Jan;297(1):3-11. Epub 2017 Sep 25 doi: 10.1007/s00404-017-4539-x. PMID: 28948431

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