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vif Vif [ Human immunodeficiency virus 1 ]

Gene ID: 155459, updated on 12-Feb-2024

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Summary

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Gene symbol: vif
Gene description: Vif
Locus tag: HIV1gp3
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Human immunodeficiency virus 1
Lineage: Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Lentivirus; Primate lentivirus group
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Genomic context

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Sequence:: NC_001802.1 (4587..5165)

NC_001802.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001802.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Direct inhibition of human APOBEC3 deaminases by HIV-1 Vif independent of the proteolysis pathway.
Title: Direct inhibition of human APOBEC3 deaminases by HIV-1 Vif independent of the proteolysis pathway.
The structural basis for HIV-1 Vif antagonism of human APOBEC3G.
Title: The structural basis for HIV-1 Vif antagonism of human APOBEC3G.
Identification of Clinically Relevant HIV Vif Protein Motif Mutations through Machine Learning and Undersampling.
Title: Identification of Clinically Relevant HIV Vif Protein Motif Mutations through Machine Learning and Undersampling.
Dominant Negative Mutants of Human Immunodeficiency Virus Type 1 Viral Infectivity Factor (Vif) Disrupt Core-Binding Factor Beta-Vif Interaction.
Title: Dominant Negative Mutants of Human Immunodeficiency Virus Type 1 Viral Infectivity Factor (Vif) Disrupt Core-Binding Factor Beta-Vif Interaction.
HIV-1 VIF and human APOBEC3G interaction directly observed through molecular specific labeling using a new dual promotor vector.
Title: HIV-1 VIF and human APOBEC3G interaction directly observed through molecular specific labeling using a new dual promotor vector.
Host AKT-mediated phosphorylation of HIV-1 accessory protein Vif potentiates infectivity via enhanced degradation of the restriction factor APOBEC3G.
Title: Host AKT-mediated phosphorylation of HIV-1 accessory protein Vif potentiates infectivity via enhanced degradation of the restriction factor APOBEC3G.
STUB1/CHIP promotes ubiquitination and degradation of HIV-1 Vif to restore the cellular level of APOBEC3G protein.
Title: STUB1/CHIP promotes ubiquitination and degradation of HIV-1 Vif to restore the cellular level of APOBEC3G protein.
Multifaceted HIV-1 Vif interactions with human E3 ubiquitin ligase and APOBEC3s.
Title: Multifaceted HIV-1 Vif interactions with human E3 ubiquitin ligase and APOBEC3s.
Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest.
Title: Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest.
High-speed atomic force microscopy directly visualizes conformational dynamics of the HIV Vif protein in complex with three host proteins.
Title: High-speed atomic force microscopy directly visualizes conformational dynamics of the HIV Vif protein in complex with three host proteins.

Submit: New GeneRIF Correction See all GeneRIFs (164)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
ATP-binding cassette sub-family E member 1	ABCE1	associates with	PubMed
ankyrin repeat and BTB/POZ domain-containing protein 2	ABTB2	upregulates	PubMed
A disintegrin and metalloproteinase with thrombospondin motifs 19	ADAMTS19	downregulates	PubMed
A disintegrin and metalloproteinase with thrombospondin motifs 3 preproprotein	ADAMTS3	upregulates	PubMed
gamma-adducin isoform b	ADD3	downregulates	PubMed
aryl hydrocarbon receptor	AHR	interacts with	PubMed
alpha-hemoglobin-stabilizing protein	AHSP	upregulates	PubMed
single-stranded DNA cytosine deaminase isoform 1	AICDA	inhibits	PubMed
apoptosis-inducing factor 1, mitochondrial isoform AIF precursor	AIFM1	interacts with	PubMed
A-kinase anchor protein 8-like isoform 1	AKAP8L	interacts with	PubMed
activating molecule in BECN1-regulated autophagy protein 1 isoform 2	AMBRA1	interacts with	PubMed
DNA dC->dU-editing enzyme APOBEC-3A isoform a	APOBEC3A	relocalizes	PubMed
	APOBEC3A	downregulates	PubMed
	APOBEC3A	co-localizes with	PubMed
DNA dC->dU-editing enzyme APOBEC-3B isoform a	APOBEC3B	degrades	PubMed
	APOBEC3B	induces ubiquitination of	PubMed
	APOBEC3B	inhibited by	PubMed
	APOBEC3B	relocalizes	PubMed
	APOBEC3B	co-localizes with	PubMed
DNA dC->dU-editing enzyme APOBEC-3C	APOBEC3C	degrades	PubMed
	APOBEC3C	degrades	PubMed
	APOBEC3C	mediates	PubMed
	APOBEC3C	binds	PubMed
	APOBEC3C	interacts with	PubMed
	APOBEC3C	interacts with	PubMed
	APOBEC3C	downregulates	PubMed
	APOBEC3C	degrades	PubMed
	APOBEC3C	co-localizes with	PubMed
	APOBEC3C	relocalizes	PubMed
	APOBEC3C	interacts with	PubMed
	APOBEC3C	regulates	PubMed
	APOBEC3C	degrades	PubMed
	APOBEC3C	degrades	PubMed
	APOBEC3C	degrades	PubMed
DNA dC->dU-editing enzyme APOBEC-3D isoform 1	APOBEC3D	interacts with	PubMed
	APOBEC3D	downregulates	PubMed
	APOBEC3D	inhibits	PubMed
	APOBEC3D	inhibited by	PubMed
	APOBEC3D	degrades	PubMed
	APOBEC3D	interacts with	PubMed
	APOBEC3D	degrades	PubMed
	APOBEC3D	inhibits	PubMed
	APOBEC3D	degrades	PubMed
DNA dC->dU-editing enzyme APOBEC-3F isoform a	APOBEC3F	binds	PubMed
	APOBEC3F	degrades	PubMed
	APOBEC3F	degrades	PubMed
	APOBEC3F	binds	PubMed
	APOBEC3F	degrades	PubMed
	APOBEC3F	degrades	PubMed
	APOBEC3F	mediates	PubMed
	APOBEC3F	binds	PubMed
	APOBEC3F	interacts with	PubMed
	APOBEC3F	inhibits	PubMed
	APOBEC3F	inhibits	PubMed
	APOBEC3F	interacts with	PubMed
	APOBEC3F	degrades	PubMed
	APOBEC3F	disrupts	PubMed
	APOBEC3F	binds	PubMed
	APOBEC3F	downregulates	PubMed
	APOBEC3F	inhibited by	PubMed
	APOBEC3F	binds	PubMed
	APOBEC3F	downregulates	PubMed
	APOBEC3F	degrades	PubMed
	APOBEC3F	binds	PubMed
	APOBEC3F	inhibits	PubMed
	APOBEC3F	interacts with	PubMed
	APOBEC3F	degrades	PubMed
	APOBEC3F	binds	PubMed
	APOBEC3F	degrades	PubMed
	APOBEC3F	degrades	PubMed
	APOBEC3F	degrades	PubMed
	APOBEC3F	interacts with	PubMed
	APOBEC3F	interacts with	PubMed
	APOBEC3F	interacts with	PubMed
	APOBEC3F	inhibits	PubMed
	APOBEC3F	inhibits	PubMed
	APOBEC3F	interacts with	PubMed
	APOBEC3F	co-localizes with	PubMed
	APOBEC3F	inhibits	PubMed
	APOBEC3F	interacts with	PubMed
	APOBEC3F	binds	PubMed
	APOBEC3F	degrades	PubMed
	APOBEC3F	binds	PubMed
	APOBEC3F	inhibits	PubMed
	APOBEC3F	interacts with	PubMed
	APOBEC3F	inhibits	PubMed
	APOBEC3F	inhibits	PubMed
	APOBEC3F	disrupts	PubMed
	APOBEC3F	disrupts	PubMed
	APOBEC3F	binds	PubMed
	APOBEC3F	inhibits	PubMed
	APOBEC3F	inhibits	PubMed
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	APOBEC3G	interacts with	PubMed
	APOBEC3G	binds	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	antagonizes	PubMed
	APOBEC3G	induces polyubiquitination of	PubMed
	APOBEC3G	counteracts	PubMed
	APOBEC3G	inhibits	PubMed
	APOBEC3G	binds	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	complexes with	PubMed
	APOBEC3G	binds	PubMed
	APOBEC3G	inhibits	PubMed
	APOBEC3G	binds	PubMed
	APOBEC3G	packages	PubMed
	APOBEC3G	antagonizes	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	induces ubiquitination of	PubMed
	APOBEC3G	inhibits	PubMed
	APOBEC3G	inhibits	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	downregulates	PubMed
	APOBEC3G	inhibits	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	inhibits	PubMed
	APOBEC3G	disrupts	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	inhibited by	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	disrupts	PubMed
	APOBEC3G	induces ubiquitination of	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	inhibits	PubMed
	APOBEC3G	downregulates	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	binds	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	downregulates	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	binds	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	binds	PubMed
	APOBEC3G	inhibits	PubMed
	APOBEC3G	binds	PubMed
	APOBEC3G	binds	PubMed
	APOBEC3G	inhibits	PubMed
	APOBEC3G	inhibits	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	inhibits	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	downregulates	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	downregulates	PubMed
	APOBEC3G	binds	PubMed
	APOBEC3G	inhibits	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	inhibited by	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	binds	PubMed
	APOBEC3G	binds	PubMed
	APOBEC3G	binds	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	binds	PubMed
	APOBEC3G	inhibited by	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	inhibits	PubMed
	APOBEC3G	inhibits	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	disrupts	PubMed
	APOBEC3G	inhibits	PubMed
	APOBEC3G	inhibits	PubMed
	APOBEC3G	inhibits	PubMed
	APOBEC3G	inhibits	PubMed
	APOBEC3G	degrades	PubMed
	APOBEC3G	downregulates	PubMed
	APOBEC3G	interacts with	PubMed
	APOBEC3G	inhibits	PubMed
	APOBEC3G	binds	PubMed
	APOBEC3G	binds	PubMed
	APOBEC3G	degrades	PubMed
DNA dC->dU-editing enzyme APOBEC-3H isoform SV-183	APOBEC3H	inhibits	PubMed
	APOBEC3H	degrades	PubMed
	APOBEC3H	degrades	PubMed
	APOBEC3H	interacts with	PubMed
	APOBEC3H	inhibits	PubMed
	APOBEC3H	interacts with	PubMed
	APOBEC3H	downregulates	PubMed
	APOBEC3H	inhibited by	PubMed
	APOBEC3H	interacts with	PubMed
	APOBEC3H	induces ubiquitination of	PubMed
	APOBEC3H	inhibits	PubMed
	APOBEC3H	inhibits	PubMed
	APOBEC3H	inhibits	PubMed
	APOBEC3H	inhibits	PubMed
	APOBEC3H	degrades	PubMed
apolipoprotein L1 isoform a precursor	APOL1	downregulated by	PubMed
	APOL1	downregulated by	PubMed
amphiregulin preproprotein	AREG	upregulates	PubMed
cysteine protease ATG4A isoform a	ATG4A	interacts with	PubMed
cysteine protease ATG4B isoform a	ATG4B	interacts with	PubMed
cysteine protease ATG4C	ATG4C	interacts with	PubMed
cysteine protease ATG4D isoform 1 precursor	ATG4D	interacts with	PubMed
serine-protein kinase ATM isoform a	ATM	downregulates	PubMed
protein ATP1B4 isoform B	ATP1B4	upregulates	PubMed
ataxin-1 isoform ATXN1	ATXN1	upregulates	PubMed
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 isoform 1	B3GAT1	upregulates	PubMed
large proline-rich protein BAG6 isoform a	BAG6	interacts with	PubMed
	BAG6	interacts with	PubMed
bromodomain adjacent to zinc finger domain protein 2A isoform 1	BAZ2A	downregulates	PubMed
nuclear nucleic acid-binding protein C1D	C1D	modulates	PubMed
complement C5 isoform 1 preproprotein	C5	downregulates	PubMed
CDK5 and ABL1 enzyme substrate 1 isoform 1	CABLES1	upregulates	PubMed
multifunctional protein CAD isoform 1	CAD	interacts with	PubMed
calcium homeostasis modulator protein 6 isoform 1	CALHM6	downregulates	PubMed
calcyphosin-2 isoform 1	CAPS2	downregulates	PubMed
capping protein, Arp2/3 and myosin-I linker protein 2 isoform 1	CARMIL2	interacts with	PubMed
cation channel sperm-associated protein 3	CATSPER3	downregulates	PubMed
core-binding factor subunit beta isoform 2	CBFB	requires	PubMed
	CBFB	interacts	PubMed
	CBFB	binds	PubMed
	CBFB	stabilized by	PubMed
	CBFB	interacts with	PubMed
	CBFB	requires	PubMed
	CBFB	interacts with	PubMed
	CBFB	complexes with	PubMed
	CBFB	stabilized by	PubMed
	CBFB	interacts with	PubMed
	CBFB	binds	PubMed
	CBFB	complexes with	PubMed
	CBFB	interacts with	PubMed
	CBFB	stabilized by	PubMed
	CBFB	disrupted by	PubMed
	CBFB	enhanced by	PubMed
	CBFB	binds	PubMed
	CBFB	complexes with	PubMed
	CBFB	binds	PubMed
	CBFB	complexes with	PubMed
	CBFB	interacts with	PubMed
	CBFB	complexes with	PubMed
	CBFB	interacts with	PubMed
	CBFB	complexes with	PubMed
	CBFB	binds	PubMed
	CBFB	enhanced by	PubMed
	CBFB	cooperates with	PubMed
	CBFB	interacts with	PubMed
	CBFB	complexes with	PubMed
	CBFB	interacts with	PubMed
	CBFB	induces ubiquitination of	PubMed
	CBFB	binds	PubMed
	CBFB	complexes with	PubMed
	CBFB	complexes with	PubMed
	CBFB	interacts with	PubMed
	CBFB	interacts with	PubMed
	CBFB	interacts with	PubMed
	CBFB	interacts with	PubMed
	CBFB	interacts with	PubMed
	CBFB	stabilized by	PubMed
	CBFB	interacts with	PubMed
	CBFB	interacts with	PubMed
	CBFB	binds	PubMed
	CBFB	interacts with	PubMed
cell cycle and apoptosis regulator protein 2 isoform 1	CCAR2	interacts with	PubMed
C-C motif chemokine 1 precursor	CCL1	downregulates	PubMed
cyclin-A1 isoform a	CCNA1	upregulates	PubMed
G2/mitotic-specific cyclin-B1 isoform 1	CCNB1	inhibits	PubMed
C-C chemokine receptor type 4	CCR4	upregulates	PubMed
C-C chemokine receptor type 7 isoform a precursor	CCR7	upregulates	PubMed
C-C chemokine receptor type 9 isoform B	CCR9	downregulates	PubMed
T-complex protein 1 subunit beta isoform 1	CCT2	interacts with	PubMed
T-complex protein 1 subunit gamma isoform a	CCT3	interacts with	PubMed
T-complex protein 1 subunit delta isoform a	CCT4	interacts with	PubMed
T-complex protein 1 subunit epsilon isoform a	CCT5	interacts with	PubMed
T-complex protein 1 subunit zeta isoform a	CCT6A	interacts with	PubMed
T-complex protein 1 subunit eta isoform a	CCT7	interacts with	PubMed
T-complex protein 1 subunit theta isoform 1	CCT8	interacts with	PubMed
vacuolar fusion protein CCZ1 homolog B	CCZ1B	downregulates	PubMed
CD226 antigen isoform a precursor	CD226	downregulates	PubMed
CMRF35-like molecule 8 isoform 1 precursor	CD300A	downregulates	PubMed
T-cell surface glycoprotein CD4 isoform 1 precursor	CD4	interacts with	PubMed
CD44 antigen isoform 1 precursor	CD44	upregulates	PubMed
ubiquitin-conjugating enzyme E2 R1	CDC34	cooperates with	PubMed
cyclin-dependent kinase 1 isoform 1	CDK1	inhibits	PubMed
	CDK1	inhibits	PubMed
cyclin-dependent kinase 9	CDK9	interacts with	PubMed
threonylcarbamoyladenosine tRNA methylthiotransferase	CDKAL1	interacts with	PubMed
cyclin-dependent kinase inhibitor 1 isoform 1	CDKN1A	upregulates	PubMed
CCAAT/enhancer-binding protein beta isoform a	CEBPB	enhanced by	PubMed
CCAAT/enhancer-binding protein epsilon	CEBPE	upregulates	PubMed
centrosomal protein of 170 kDa isoform alpha	CEP170	interacts with	PubMed
C-type lectin domain family 2 member D isoform 1	CLEC2D	downregulates	PubMed
collectin-12	COLEC12	downregulates	PubMed
complement receptor type 2 isoform 2 precursor	CR2	downregulates	PubMed
macrophage colony-stimulating factor 1 isoform a precursor	CSF1	upregulates	PubMed
granulocyte-macrophage colony-stimulating factor precursor	CSF2	upregulates	PubMed
cullin-2 isoform c	CUL2	interacts with	PubMed
cullin-4A isoform 2	CUL4A	interacts with	PubMed
cullin-5	CUL5	interacts with	PubMed
	CUL5	interacts with	PubMed
	CUL5	complexes with	PubMed
	CUL5	complexes with	PubMed
	CUL5	complexes with	PubMed
	CUL5	interacts with	PubMed
	CUL5	complexes with	PubMed
	CUL5	binds	PubMed
	CUL5	complexes with	PubMed
	CUL5	interacts with	PubMed
	CUL5	complexes with	PubMed
	CUL5	complexes with	PubMed
	CUL5	complexes with	PubMed
	CUL5	interacts with	PubMed
	CUL5	binds	PubMed
	CUL5	interacts with	PubMed
	CUL5	interacts with	PubMed
	CUL5	interacts with	PubMed
	CUL5	complexes with	PubMed
	CUL5	interacts with	PubMed
	CUL5	interacts with	PubMed
	CUL5	requires	PubMed
	CUL5	interacts with	PubMed
	CUL5	interacts with	PubMed
	CUL5	inhibited by	PubMed
	CUL5	regulated by	PubMed
	CUL5	interacts with	PubMed
	CUL5	interacts with	PubMed
C-X-C chemokine receptor type 3 isoform 1	CXCR3	upregulates	PubMed
cytochrome P450 3A7	CYP3A7	downregulates	PubMed
CYFIP-related Rac1 interactor A	CYRIA	upregulates	PubMed
DDB1- and CUL4-associated factor 11 isoform 1	DCAF11	interacts with	PubMed
DNA damage-binding protein 1	DDB1	interacts with	PubMed
7-dehydrocholesterol reductase isoform 1	DHCR7	upregulates	PubMed
ATP-dependent RNA helicase A	DHX9	regulated by	PubMed
dnaJ homolog subfamily A member 1 isoform 1	DNAJA1	interacts with	PubMed
dnaJ homolog subfamily A member 2	DNAJA2	interacts with	PubMed
dnaJ homolog subfamily B member 2 isoform b	DNAJB2	interacts with	PubMed
dnaJ homolog subfamily C member 7 isoform 1	DNAJC7	interacts with	PubMed
dual specificity protein phosphatase 1	DUSP1	upregulates	PubMed
egl nine homolog 1 isoform 1	EGLN1	downregulates	PubMed
interferon-induced, double-stranded RNA-activated protein kinase isoform a	EIF2AK2	regulated by	PubMed
eukaryotic translation initiation factor 4E type 3 isoform b	EIF4E3	upregulates	PubMed
elongin-B isoform a	ELOB	complexes with	PubMed
	ELOB	interacts with	PubMed
	ELOB	complexes with	PubMed
	ELOB	complexes with	PubMed
	ELOB	complexes with	PubMed
	ELOB	complexes with	PubMed
	ELOB	interacts with	PubMed
	ELOB	complexes with	PubMed
	ELOB	complexes with	PubMed
	ELOB	binds	PubMed
	ELOB	stabilized by	PubMed
	ELOB	interacts with	PubMed
	ELOB	interacts with	PubMed
	ELOB	enhanced by	PubMed
	ELOB	complexes with	PubMed
	ELOB	binds	PubMed
elongin-C isoform a	ELOC	complexes with	PubMed
	ELOC	interacts with	PubMed
	ELOC	interacts with	PubMed
	ELOC	interacts with	PubMed
	ELOC	complexes with	PubMed
	ELOC	complexes with	PubMed
	ELOC	interacts with	PubMed
	ELOC	complexes with	PubMed
	ELOC	interacts with	PubMed
	ELOC	interacts with	PubMed
	ELOC	complexes with	PubMed
	ELOC	complexes with	PubMed
	ELOC	binds	PubMed
	ELOC	enhanced by	PubMed
	ELOC	complexes with	PubMed
	ELOC	interacts with	PubMed
	ELOC	interacts with	PubMed
	ELOC	complexes with	PubMed
	ELOC	binds	PubMed
GTPase Era, mitochondrial isoform 1	ERAL1	interacts with	PubMed
ERBB receptor feedback inhibitor 1	ERRFI1	downregulates	PubMed
proteinase-activated receptor 3 isoform 1 precursor	F2RL2	downregulates	PubMed
tissue factor isoform 1 precursor	F3	upregulates	PubMed
fatty acid synthase	FASN	interacts with	PubMed
fibroblast growth factor-binding protein 2 precursor	FGFBP2	downregulates	PubMed
fibroleukin precursor	FGL2	downregulates	PubMed
fascin	FSCN1	upregulates	PubMed
trifunctional purine biosynthetic protein adenosine-3 isoform 1	GART	interacts with	PubMed
endothelial transcription factor GATA-2 isoform 1	GATA2	upregulates	PubMed
guanylate-binding protein 4	GBP4	upregulates	PubMed
guanylate-binding protein 5 isoform 1	GBP5	downregulates	PubMed
GDNF family receptor alpha-1 isoform a preproprotein	GFRA1	downregulates	PubMed
GTPase IMAP family member 6 isoform 1	GIMAP6	downregulates	PubMed
GLIPR1-like protein 1 isoform 2 precursor	GLIPR1L1	downregulates	PubMed
glycine receptor subunit beta isoform A precursor	GLRB	downregulates	PubMed
G-protein coupled receptor 183	GPR183	upregulates	PubMed
G-protein coupled receptor 52	GPR52	downregulates	PubMed
G-protein coupled receptor 55	GPR55	upregulates	PubMed
G protein pathway suppressor 2	GPS2	interacts with	PubMed
GRB2-related adapter protein isoform 1	GRAP	downregulates	PubMed
glutathione S-transferase A4	GSTA4	downregulates	PubMed
granzyme B isoform 1 preproprotein	GZMB	upregulates	PubMed
GDH/6PGL endoplasmic bifunctional protein isoform 2 precursor	H6PD	downregulates	PubMed
trifunctional enzyme subunit alpha, mitochondrial precursor	HADHA	interacts with	PubMed
tyrosine-protein kinase HCK isoform a	HCK	interacts with	PubMed
	HCK	inhibits	PubMed
histone deacetylase 3 isoform 2	HDAC3	interacts with	PubMed
histone deacetylase 6 isoform a	HDAC6	interacts with	PubMed
	HDAC6	degradation is mediated by	PubMed
	HDAC6	inhibited by	PubMed
	HDAC6	complexes with	PubMed
	HDAC6	binds	PubMed
	HDAC6	decreased by	PubMed
HLA class II histocompatibility antigen, DQ beta 1 chain isoform 1 precursor	HLA-DQB1	downregulates	PubMed
major histocompatibility complex, class II, DR beta 1 precursor	HLA-DRB1	interacts with	PubMed
heterogeneous nuclear ribonucleoproteins A2/B1 isoform A2	HNRNPA2B1	regulated by	PubMed
	HNRNPA2B1	regulated by	PubMed
heterogeneous nuclear ribonucleoprotein F	HNRNPF	regulated by	PubMed
	HNRNPF	regulated by	PubMed
heterogeneous nuclear ribonucleoprotein H isoform a	HNRNPH1	regulated by	PubMed
	HNRNPH1	regulated by	PubMed
BLOC-2 complex member HPS6	HPS6	interacts with	PubMed
heat shock protein HSP 90-alpha isoform 1	HSP90AA1	interacts with	PubMed
heat shock 70 kDa protein 1A	HSPA1A	interacts with	PubMed
heat shock 70 kDa protein 4	HSPA4	interacts with	PubMed
heat shock cognate 71 kDa protein isoform 1	HSPA8	interacts with	PubMed
heat shock protein beta-1	HSPB1	interacts with	PubMed
60 kDa heat shock protein, mitochondrial	HSPD1	interacts with	PubMed
E3 ubiquitin-protein ligase HUWE1	HUWE1	interacts with	PubMed
isoleucine--tRNA ligase, mitochondrial precursor	IARS2	interacts with	PubMed
islet cell autoantigen 1 isoform a	ICA1	downregulates	PubMed
interferon-induced protein with tetratricopeptide repeats 3 isoform a	IFIT3	downregulates	PubMed
interferon-induced transmembrane protein 1	IFITM1	downregulated by	PubMed
interferon-induced transmembrane protein 2	IFITM2	downregulated by	PubMed
interferon-induced transmembrane protein 3	IFITM3	downregulated by	PubMed
	IFITM3	downregulated by	PubMed
interferon alpha-1/13 precursor	IFNA1	inhibited by	PubMed
interferon alpha-10 precursor	IFNA10	inhibited by	PubMed
	IFNA13	inhibited by	PubMed
interferon alpha-14 precursor	IFNA14	inhibited by	PubMed
interferon alpha-16 precursor	IFNA16	inhibited by	PubMed
interferon alpha-17 precursor	IFNA17	inhibited by	PubMed
interferon alpha-2 precursor	IFNA2	inhibited by	PubMed
interferon alpha-21 precursor	IFNA21	inhibited by	PubMed
interferon alpha-4 precursor	IFNA4	inhibited by	PubMed
interferon alpha-5 precursor	IFNA5	inhibited by	PubMed
interferon alpha-6 precursor	IFNA6	inhibited by	PubMed
interferon alpha-7 precursor	IFNA7	inhibited by	PubMed
interferon alpha-8 precursor	IFNA8	inhibited by	PubMed
interferon beta precursor	IFNB1	inhibits	PubMed
interferon gamma precursor	IFNG	downregulates	PubMed
intraflagellar transport protein 70A	IFT70A	downregulates	PubMed
zinc finger protein Aiolos isoform 1	IKZF3	interacts with	PubMed
	IKZF3	downregulates	PubMed
interleukin-10 isoform 1 precursor	IL10	upregulates	PubMed
interleukin-23 receptor precursor	IL23R	upregulates	PubMed
interleukin-31 receptor subunit alpha isoform 1	IL31RA	modulates	PubMed
interleukin-4 isoform 1 precursor	IL4	upregulates	PubMed
interleukin-7 receptor subunit alpha isoform 1 precursor	IL7R	upregulates	PubMed
interleukin-9 receptor isoform 1 precursor	IL9R	interacts with	PubMed
insulin-induced gene 1 protein isoform 1	INSIG1	upregulates	PubMed
interferon regulatory factor 1 isoform 1	IRF1	downregulates	PubMed
interferon regulatory factor 3 isoform 1	IRF3	induces cleavage of	PubMed
	IRF3	degrades	PubMed
isthmin-1 precursor	ISM1	upregulates	PubMed
E3 ubiquitin-protein ligase Itchy homolog isoform 2	ITCH	binds	PubMed
integrin alpha-6 isoform b preproprotein	ITGA6	downregulates	PubMed
KH domain-containing, RNA-binding, signal transduction-associated protein 3	KHDRBS3	upregulates	PubMed
sickle tail protein homolog isoform 1	KIAA1217	interacts with	PubMed
	KIAA1217	upregulates	PubMed
kinesin-like protein KIF11	KIF11	interacts with	PubMed
kinesin-like protein KIF26B	KIF26B	interacts with	PubMed
Krueppel-like factor 2	KLF2	downregulates	PubMed
lysine-rich nucleolar protein 1 isoform b	KNOP1	downregulates	PubMed
low-density lipoprotein receptor isoform 1 precursor	LDLR	upregulates	PubMed
lipopolysaccharide-induced tumor necrosis factor-alpha factor isoform 1	LITAF	upregulates	PubMed
LON peptidase N-terminal domain and RING finger protein 2 isoform 1	LONRF2	downregulates	PubMed
lymphocyte antigen 96 isoform 1 precursor	LY96	upregulates	PubMed
mastermind-like protein 2	MAML2	downregulates	PubMed
mastermind-like domain-containing protein 1 isoform 2	MAMLD1	upregulates	PubMed
microtubule-associated protein 1B isoform 1	MAP1B	interacts with	PubMed
	MAP1B	downregulates	PubMed
microtubule-associated proteins 1A/1B light chain 3A isoform a	MAP1LC3A	binds	PubMed
	MAP1LC3A	binds	PubMed
	MAP1LC3A	interacts with	PubMed
microtubule-associated proteins 1A/1B light chain 3B	MAP1LC3B	binds	PubMed
	MAP1LC3B	binds	PubMed
	MAP1LC3B	interacts with	PubMed
microtubule-associated proteins 1A/1B light chain 3C	MAP1LC3C	binds	PubMed
	MAP1LC3C	binds	PubMed
	MAP1LC3C	interacts with	PubMed
mitogen-activated protein kinase kinase kinase 5	MAP3K5	inhibited by	PubMed
	MAP3K5	inhibited by	PubMed
	MAP3K5	inhibited by	PubMed
	MAP3K5	binds	PubMed
	MAP3K5	binds	PubMed
mitogen-activated protein kinase 1	MAPK1	phosphorylated by	PubMed
mitogen-activated protein kinase 3 isoform 1	MAPK3	phosphorylated by	PubMed
E3 ubiquitin-protein ligase Mdm2 isoform a	MDM2	binds	PubMed
	MDM2	interacts with	PubMed
	MDM2	degraded by	PubMed
	MDM2	binds	PubMed
	MDM2	inhibits	PubMed
neprilysin isoform a	MME	upregulates	PubMed
meiosis-specific nuclear structural protein 1	MNS1	downregulates	PubMed
mitochondrial peptide methionine sulfoxide reductase isoform a precursor	MSRA	downregulates	PubMed
monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform 1 precursor	MTHFD1L	interacts with	PubMed
methionine synthase isoform 1	MTR	interacts with	PubMed
mevalonate kinase isoform a	MVK	upregulates	PubMed
nascent polypeptide-associated complex subunit alpha isoform a	NACA	interacts with	PubMed
nuclear receptor corepressor 1 isoform 1	NCOR1	interacts with	PubMed
E3 ubiquitin-protein ligase NEDD4 isoform 1	NEDD4	binds	PubMed
NEDD8	NEDD8	complexes with	PubMed
	NEDD8	complexes with	PubMed
pro-FMRFamide-related neuropeptide FF isoform 1 preproprotein	NPFF	upregulates	PubMed
nuclear receptor subfamily 4 group A member 2 isoform a	NR4A2	upregulates	PubMed
nardilysin isoform a	NRDC	interacts with	PubMed
5'-nucleotidase isoform 1 preproprotein	NT5E	upregulates	PubMed
P2Y purinoceptor 14	P2RY14	downregulates	PubMed
partitioning defective 6 homolog gamma	PARD6G	modulates	PubMed
poly(rC)-binding protein 3 isoform 1	PCBP3	downregulates	PubMed
high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform a	PDE9A	downregulates	PubMed
p53 apoptosis effector related to PMP-22	PERP	upregulates	PubMed
phosphoribosylformylglycinamidine synthase	PFAS	interacts with	PubMed
phosphatase and actin regulator 2 isoform 3	PHACTR2	downregulates	PubMed
phosphatidylinositol-glycan biosynthesis class F protein isoform 1	PIGF	downregulates	PubMed
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	PIN1	interacts with	PubMed
zinc finger protein PLAGL1 isoform 2	PLAGL1	downregulates	PubMed
urokinase-type plasminogen activator isoform 1 preproprotein	PLAU	upregulates	PubMed
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform a	PLCB1	downregulates	PubMed
PI-PLC X domain-containing protein 2 isoform b	PLCXD2	upregulates	PubMed
plectin isoform 1c	PLEC	relocalizes	PubMed
polyamine-modulated factor 1-binding protein 1 isoform a	PMFBP1	downregulates	PubMed
DNA-directed RNA polymerase II subunit RPB1	POLR2A	interacts with	PubMed
DNA-directed RNA polymerase II subunit RPB2 isoform 1	POLR2B	interacts with	PubMed
peroxisome proliferator-activated receptor gamma isoform 1	PPARG	downregulates	PubMed
peptidyl-prolyl cis-trans isomerase A isoform 1	PPIA	binds	PubMed
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform 1	PPP2R5A	degrades	PubMed
	PPP2R5A	binds	PubMed
	PPP2R5A	downregulates	PubMed
5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1	PRKAA1	inhibited by	PubMed
5'-AMP-activated protein kinase catalytic subunit alpha-2	PRKAA2	inhibited by	PubMed
5'-AMP-activated protein kinase subunit beta-1	PRKAB1	inhibited by	PubMed
5'-AMP-activated protein kinase subunit beta-2	PRKAB2	inhibited by	PubMed
cAMP-dependent protein kinase catalytic subunit alpha isoform Calpha1	PRKACA	inhibited by	PubMed
cAMP-dependent protein kinase catalytic subunit beta isoform 2	PRKACB	inhibited by	PubMed
cAMP-dependent protein kinase catalytic subunit gamma	PRKACG	inhibited by	PubMed
5'-AMP-activated protein kinase subunit gamma-1 isoform 1	PRKAG1	inhibited by	PubMed
cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a	PRKAR1A	inhibited by	PubMed
cAMP-dependent protein kinase type I-beta regulatory subunit	PRKAR1B	inhibited by	PubMed
cAMP-dependent protein kinase type II-alpha regulatory subunit isoform a	PRKAR2A	inhibited by	PubMed
cAMP-dependent protein kinase type II-beta regulatory subunit	PRKAR2B	inhibited by	PubMed
prolactin precursor	PRL	downregulates	PubMed
prokineticin-2 isoform b precursor	PROK2	upregulates	PubMed
proteasome subunit alpha type-2	PSMA2	interacts with	PubMed
proteasome subunit alpha type-3 isoform 1	PSMA3	interacts with	PubMed
proteasome subunit alpha type-5 isoform 1	PSMA5	interacts with	PubMed
proteasome subunit alpha type-6 isoform a	PSMA6	interacts with	PubMed
proteasome subunit alpha type-7	PSMA7	interacts with	PubMed
proteasome subunit beta type-10	PSMB10	interacts with	PubMed
proteasome subunit beta type-2 isoform 1	PSMB2	interacts with	PubMed
proteasome subunit beta type-3	PSMB3	interacts with	PubMed
proteasome subunit beta type-4	PSMB4	interacts with	PubMed
proteasome subunit beta type-5 isoform 1	PSMB5	interacts with	PubMed
proteasome subunit beta type-6 isoform 1	PSMB6	interacts with	PubMed
proteasome subunit beta type-7 precursor	PSMB7	interacts with	PubMed
26S proteasome regulatory subunit 4 isoform a	PSMC1	interacts with	PubMed
26S proteasome regulatory subunit 7 isoform 1	PSMC2	interacts with	PubMed
26S proteasome regulatory subunit 6A	PSMC3	interacts with	PubMed
26S proteasome regulatory subunit 6B isoform 1	PSMC4	interacts with	PubMed
26S proteasome regulatory subunit 8 isoform 1	PSMC5	interacts with	PubMed
26S proteasome regulatory subunit 10B	PSMC6	interacts with	PubMed
26S proteasome non-ATPase regulatory subunit 1 isoform 1	PSMD1	interacts with	PubMed
26S proteasome non-ATPase regulatory subunit 10 isoform 1	PSMD10	interacts with	PubMed
26S proteasome non-ATPase regulatory subunit 11	PSMD11	interacts with	PubMed
26S proteasome non-ATPase regulatory subunit 12 isoform 1	PSMD12	interacts with	PubMed
26S proteasome non-ATPase regulatory subunit 13 isoform 1	PSMD13	interacts with	PubMed
26S proteasome non-ATPase regulatory subunit 2 isoform 1	PSMD2	interacts with	PubMed
26S proteasome non-ATPase regulatory subunit 3	PSMD3	interacts with	PubMed
26S proteasome non-ATPase regulatory subunit 4 isoform 2	PSMD4	interacts with	PubMed
26S proteasome non-ATPase regulatory subunit 5 isoform 1	PSMD5	interacts with	PubMed
26S proteasome non-ATPase regulatory subunit 6 isoform 2	PSMD6	interacts with	PubMed
26S proteasome non-ATPase regulatory subunit 7	PSMD7	interacts with	PubMed
26S proteasome non-ATPase regulatory subunit 8	PSMD8	interacts with	PubMed
26S proteasome non-ATPase regulatory subunit 9 isoform 1	PSMD9	interacts with	PubMed
proteasome activator complex subunit 1 isoform 1	PSME1	interacts with	PubMed
proteasome activator complex subunit 2	PSME2	interacts with	PubMed
proteasome activator complex subunit 3 isoform 1	PSME3	interacts with	PubMed
	PSME3	interacts with	PubMed
proteasome activator complex subunit 4	PSME4	interacts with	PubMed
proteasome inhibitor PI31 subunit isoform 1	PSMF1	interacts with	PubMed
purine-rich element-binding protein gamma isoform A	PURG	modulates	PubMed
ras-related protein Rab-7a	RAB7A	regulated by	PubMed
V(D)J recombination-activating protein 2	RAG2	downregulates	PubMed
RNA-binding protein 34 isoform 1	RBM34	downregulates	PubMed
E3 ubiquitin-protein ligase RBX1	RBX1	complexes with	PubMed
	RBX1	interacts with	PubMed
	RBX1	interacts with	PubMed
	RBX1	complexes with	PubMed
rho-related GTP-binding protein RhoU	RHOU	downregulates	PubMed
rho-related GTP-binding protein RhoE precursor	RND3	modulates	PubMed
E3 ubiquitin-protein ligase RNF216 isoform a	RNF216	binds	PubMed
	RNF216	interacts with	PubMed
	RNF216	binds	PubMed
	RNF216	binds	PubMed
RING-box protein 2 isoform 1	RNF7	interacts with	PubMed
	RNF7	complexes with	PubMed
	RNF7	interacts with	PubMed
	RNF7	complexes with	PubMed
	RNF7	interacts with	PubMed
nuclear receptor ROR-beta isoform 1	RORB	upregulates	PubMed
replication protein A 32 kDa subunit isoform 1	RPA2	inhibited by	PubMed
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 isoform 1	RSAD2	downregulates	PubMed
runt-related transcription factor 1 isoform AML1c	RUNX1	inhibits	PubMed
	RUNX1	inhibits	PubMed
	RUNX1	regulates	PubMed
	RUNX1	interacts with	PubMed
	RUNX1	interacts with	PubMed
runt-related transcription factor 2 isoform b	RUNX2	inhibits	PubMed
runt-related transcription factor 3 isoform 2	RUNX3	inhibits	PubMed
sphingosine 1-phosphate receptor 1	S1PR1	downregulates	PubMed
diamine acetyltransferase 1	SAT1	modulates	PubMed
	SAT1	binds	PubMed
sodium channel protein type 3 subunit alpha isoform 1	SCN3A	downregulates	PubMed
monocarboxylate transporter 7	SLC16A6	downregulates	PubMed
solute carrier family 22 member 1 isoform a	SLC22A1	upregulates	PubMed
mitochondrial 2-oxodicarboxylate carrier isoform 1	SLC25A21	downregulates	PubMed
sodium- and chloride-dependent transporter XTRP3 isoform 1	SLC6A20	downregulates	PubMed
schlafen family member 5 isoform 1	SLFN5	interacts with	PubMed
slit homolog 2 protein isoform 1 precursor	SLIT2	upregulates	PubMed
mothers against decapentaplegic homolog 1	SMAD1	upregulates	PubMed
SPARC-related modular calcium-binding protein 1 isoform 2 precursor	SMOC1	upregulates	PubMed
superoxide dismutase	SOD2	upregulates	PubMed
nuclear body protein SP140 isoform 1	SP140	binds	PubMed
	SP140	interacts with	PubMed
	SP140	binds	PubMed
spondin-1 precursor	SPON1	downregulates	PubMed
protein sprouty homolog 1	SPRY1	upregulates	PubMed
SPRY domain-containing SOCS box protein 1	SPSB1	downregulates	PubMed
sequestosome-1 isoform 1	SQSTM1	interacts with	PubMed
serine/arginine-rich splicing factor 4	SRSF4	regulated by	PubMed
statherin isoform a precursor	STATH	upregulates	PubMed
E3 ubiquitin-protein ligase CHIP isoform a	STUB1	interacts with	PubMed
taste receptor type 2 member 40	TAS2R40	downregulates	PubMed
serine/threonine-protein kinase TBK1	TBK1	interacts with	PubMed
F-box-like/WD repeat-containing protein TBL1XR1 isoform 1	TBL1XR1	interacts with	PubMed
T-box transcription factor TBX21	TBX21	downregulates	PubMed
T-complex protein 1 subunit alpha isoform a	TCP1	interacts with	PubMed
transferrin receptor protein 1 isoform 1	TFRC	interacts with	PubMed
transducin-like enhancer protein 1 isoform 2	TLE1	upregulates	PubMed
toll-like receptor 5 precursor	TLR5	downregulates	PubMed
protein O-mannosyl-transferase TMTC2 isoform 1 precursor	TMTC2	upregulates	PubMed
tumor necrosis factor receptor superfamily member 10D precursor	TNFRSF10D	upregulates	PubMed
tumor necrosis factor receptor superfamily member 14 isoform 1 precursor	TNFRSF14	downregulates	PubMed
tumor necrosis factor receptor superfamily member 8 isoform 1 precursor	TNFRSF8	upregulates	PubMed
tumor necrosis factor ligand superfamily member 10 isoform 1	TNFSF10	downregulates	PubMed
tumor necrosis factor ligand superfamily member 15 isoform VEGI-251 precursor	TNFSF15	upregulates	PubMed
tumor necrosis factor ligand superfamily member 8 isoform 1	TNFSF8	upregulates	PubMed
cellular tumor antigen p53 isoform a	TP53	stabilizes	PubMed
	TP53	binds	PubMed
thiamine pyrophosphokinase 1 isoform a	TPK1	upregulates	PubMed
TNF receptor-associated factor 1 isoform a	TRAF1	upregulates	PubMed
TRAF3-interacting JNK-activating modulator isoform 1	TRAF3IP3	downregulates	PubMed
thyrotropin-releasing hormone receptor	TRHR	downregulates	PubMed
E3 ubiquitin-protein ligase TRIM36 isoform 1	TRIM36	downregulates	PubMed
tetratricopeptide repeat protein 28 isoform 1	TTC28	downregulates	PubMed
beta-taxilin	TXLNB	downregulates	PubMed
uveal autoantigen with coiled-coil domains and ankyrin repeats isoform 1	UACA	downregulates	PubMed
ubiquitin-like modifier-activating enzyme 1	UBA1	dependent on	PubMed
polyubiquitin-B precursor	UBB	inhibited by	PubMed
polyubiquitin-C	UBC	inhibited by	PubMed
ubiquitin-conjugating enzyme E2 D2 isoform 1	UBE2D2	cooperates with	PubMed
NEDD8-conjugating enzyme UBE2F isoform 1	UBE2F	interacts with	PubMed
	UBE2F	interacts with	PubMed
	UBE2F	interacts with	PubMed
ubiquitin-like protein 4A	UBL4A	interacts with	PubMed
E3 ubiquitin-protein ligase UBR2 isoform 1	UBR2	interacts with	PubMed
putative mitochondrial transporter UCP3 isoform UCP3L	UCP3	downregulates	PubMed
UL16-binding protein 1 isoform 1 precursor	ULBP1	downregulates	PubMed
	ULBP1	inhibits	PubMed
	ULBP1	inhibits	PubMed
UL16-binding protein 2 preproprotein	ULBP2	inhibits	PubMed
	ULBP2	downregulates	PubMed
	ULBP2	inhibits	PubMed
UL16-binding protein 3 precursor	ULBP3	downregulates	PubMed
	ULBP3	inhibits	PubMed
	ULBP3	inhibits	PubMed
vimentin	VIM	co-localizes with	PubMed
WD repeat-containing protein 6 isoform 1	WDR6	interacts with	PubMed
XIAP-associated factor 1 isoform 1	XAF1	downregulates	PubMed
xin actin-binding repeat-containing protein 1 isoform 1	XIRP1	upregulates	PubMed
X-ray repair cross-complementing protein 6 isoform 1	XRCC6	binds	PubMed
xylosyltransferase 1	XYLT1	modulates	PubMed
zinc finger and BTB domain-containing protein 16 isoform 1	ZBTB16	downregulates	PubMed
zinc finger protein 774	ZNF774	upregulates	PubMed