Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

B-Cell Lymphoproliferative Disorder

MedGen UID:: 1791871
•Concept ID:: C5555430
•: Disease or Syndrome

Definition

A non-neoplastic or neoplastic proliferation of B-lymphocytes. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVB-Cell Lymphoproliferative Disorder

Pathological process
- Disease
  - Disorder by Site
    - Hematopoietic and Lymphoid System Disorder
      - Hematologic disorder
        Lymphoproliferative disorder
        B-Cell Lymphoproliferative Disorder
        B-cell lymphoma
        Advanced B-Cell Malignant Neoplasm
        Advanced Diffuse Large B-Cell Lymphoma
        Advanced Follicular Lymphoma
        Advanced Marginal Zone Lymphoma
        Aggressive B-cell non-Hodgkin lymphoma
        AIDS-Related Diffuse Large B-cell Lymphoma
        B Lymphoblastic Lymphoma
        B-cell prolymphocytic leukemia
        Burkitt lymphoma
        Diffuse large B-cell lymphoma activated B-cell type
        Diffuse Large B-Cell Lymphoma Post-Transplant Lymphoproliferative Disorder
        Diffuse Large B-Cell Lymphoma Unclassifiable
        Grade III lymphomatoid granulomatosis
        High grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement
        Large B-Cell Lymphoma with 11q Aberration
        Malignant lymphoma, centroblastic type, follicular
        Mantle cell lymphoma
        Plasmablastic lymphoma
        Primary cutaneous diffuse large B-cell lymphoma, Leg type
        Primary effusion lymphoma
        Recurrent Aggressive B-Cell Non-Hodgkin Lymphoma
        Refractory Aggressive B-Cell Non-Hodgkin Lymphoma
        AIDS-Related Lymphoma
        AIDS-Related Hodgkin Lymphoma
        AIDS-Related Non-Hodgkin Lymphoma
        AIDS-related primary central nervous system lymphoma
        Ann Arbor Stage I AIDS-Related Lymphoma
        Ann Arbor Stage II AIDS-Related Lymphoma
        Ann Arbor Stage III AIDS-Related Lymphoma
        Ann Arbor Stage IV AIDS-Related Lymphoma
        B Lymphoblastic Leukemia/Lymphoma
        B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified
        B-cell acute lymphoblastic leukemia
        B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality
        Cutaneous B Lymphoblastic Leukemia/Lymphoma
        B-Cell Non-Hodgkin Lymphoma by Ann Arbor Stage
        Ann Arbor Stage I B-Cell Non-Hodgkin Lymphoma
        Ann Arbor Stage II B-Cell Non-Hodgkin Lymphoma
        Ann Arbor Stage III B-Cell Non-Hodgkin Lymphoma
        Ann Arbor Stage IV B-Cell Non-Hodgkin Lymphoma
        B Lymphoblastic Lymphoma by Ann Arbor Stage
        Burkitt Lymphoma by Ann Arbor Stage
        Diffuse Large B-Cell Lymphoma by Ann Arbor Stage
        Follicular Lymphoma by Ann Arbor Stage
        Lymphoplasmacytic Lymphoma by Ann Arbor Stage
        Mantle Cell Lymphoma by Ann Arbor Stage
        Marginal Zone Lymphoma by Ann Arbor Stage
        Small Lymphocytic Lymphoma by Ann Arbor Stage
        Central Nervous System B-Cell Non-Hodgkin Lymphoma
        Diffuse large B-cell lymphoma of the central nervous system
        Dural Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
        Follicular lymphoma
        Breast Follicular Lymphoma
        Conjunctival Follicular Lymphoma
        Cutaneous Follicular Lymphoma
        Duodenal-Type Follicular Lymphoma
        Follicular Lymphoma with Predominantly Diffuse Growth Pattern
        Grade 1 Follicular Lymphoma
        Grade 2 Follicular Lymphoma
        High Grade B-Cell Lymphoma with Blastoid Morphologic Features
        Intestinal Follicular Lymphoma
        Lacrimal Gland Follicular Lymphoma
        Lung Follicular Lymphoma
        Methotrexate-Associated Follicular Lymphoma
        Pediatric-Type Follicular Lymphoma
        Predominantly Diffuse Follicular Lymphoma with 1p36 Deletion
        Prostate Follicular Lymphoma
        Recurrent Follicular Lymphoma
        Refractory Follicular Lymphoma
        Salivary Gland Follicular Lymphoma
        Splenic Follicular Lymphoma
        Testicular Follicular Lymphoma
        Thyroid Gland Follicular Lymphoma
        Lymphomatoid granulomatosis
        Childhood Lymphomatoid Granulomatosis
        Cutaneous Lymphomatoid Granulomatosis
        Grade I lymphomatoid granulomatosis
        Grade II lymphomatoid granulomatosis
        Recurrent Lymphomatoid Granulomatosis
        Malignant lymphoma, large B-cell, diffuse
        Adult Diffuse Large B-Cell Lymphoma
        ALK-positive large B-cell lymphoma
        Breast diffuse large B-cell lymphoma
        Childhood Diffuse Large B-Cell Lymphoma
        Conjunctival Diffuse Large B-Cell Lymphoma
        Diffuse Large B-Cell Lymphoma Arising in HHV8-Positive Multicentric Castleman Disease
        Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation
        Diffuse large B-cell lymphoma with chronic inflammation
        Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
        Digestive System Diffuse Large B-Cell Lymphoma
        Double-Expressor Lymphoma
        Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly
        HHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
        High grade B-cell lymphoma
        Intravascular large B-cell lymphoma
        Kidney Diffuse Large B-Cell Lymphoma
        Lacrimal System Diffuse Large B-Cell Lymphoma
        Methotrexate-Associated Diffuse Large B-Cell Lymphoma
        Paranasal Sinus Diffuse Large B-Cell Lymphoma
        Primary Bone Diffuse Large B-Cell Lymphoma
        Primary Cutaneous Diffuse Large B-Cell Lymphoma
        Primary Diffuse Large B-Cell Lymphoma of the Testis
        Primary mediastinal large B-cell lymphoma
        Primary pulmonary diffuse large B-cell lymphoma
        Prostate Diffuse Large B-Cell Lymphoma
        Recurrent Diffuse Large B-Cell Lymphoma
        Relapsed/refractory diffuse large B-cell lymphoma
        Salivary Gland Diffuse Large B-Cell Lymphoma
        Splenic diffuse large B-cell lymphoma
        T-cell/histiocyte rich large B cell lymphoma
        Thyroid gland diffuse large B-cell lymphoma
        Mature B-Cell Non-Hodgkin Lymphoma
        Heavy chain disease
        Indolent B-cell non-Hodgkin lymphoma
        Large B-Cell Lymphoma with IRF4 Rearrangement
        Primary Cutaneous B-Cell Non-Hodgkin Lymphoma
        Recurrent Mature B-Cell Non-Hodgkin Lymphoma
        Refractory Mature B-Cell Non-Hodgkin Lymphoma
        Small Lymphocytic Lymphoma
        Splenic diffuse red pulp small B-cell lymphoma
        Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma
        Mucosa-associated lymphoma
        Bladder Mucosa-Associated Lymphoid Tissue Lymphoma
        Breast mucosa-associated lymphoid tissue lymphoma
        Childhood Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
        Endometrial Mucosa-Associated Lymphoid Tissue Lymphoma
        Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue by Ann Arbor Stage
        Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue Involving the Digestive System
        Lung Mucosa-Associated Lymphoid Tissue Lymphoma
        Ocular Adnexal Mucosa-Associated Lymphoid Tissue Lymphoma
        Recurrent Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
        Refractory Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
        Salivary Gland Mucosa-Associated Lymphoid Tissue Lymphoma
        Thymic Mucosa-Associated Lymphoid Tissue Lymphoma
        Thyroid gland mucosa-associated lymphoid tissue lymphoma
        Neoplasm of mature B-cells
        B-Cell Proliferation of Uncertain Malignant Potential
        Burkitt Leukemia
        Chronic lymphocytic leukemia/small lymphocytic lymphoma
        Cutaneous Mature B-Cell Neoplasm
        Hairy cell leukemia
        Lung Mature B-Cell Neoplasm
        Monoclonal B-Cell Lymphocytosis
        Monomorphic B-Cell Post-Transplant Lymphoproliferative Disorder
        Plasma cell neoplasm
        Splenic B-Cell Lymphoma/Leukemia, Unclassifiable
        Recurrent B-Cell Non-Hodgkin Lymphoma
        Refractory B-Cell Non-Hodgkin Lymphoma
        Small Intestinal B-Cell Non-Hodgkin Lymphoma
        Alpha-heavy chain disease
        Small intestinal Burkitt lymphoma
        Small intestinal diffuse large B-cell lymphoma
        Small Intestinal Follicular Lymphoma
        Small Intestinal Mantle Cell Lymphoma
        Small intestinal mucosa-associated lymphoid tissue lymphoma
        EBV positive mucocutaneous ulcer
        Follicular Bronchitis/Bronchiolitis
        Nodular lymphocyte predominant Hodgkin lymphoma
        Adult nodular lymphocyte predominant Hodgkin lymphoma
        Childhood Nodular Lymphocyte Predominant B-Cell Lymphoma
        Nodular Lymphocyte Predominant B-Cell Lymphoma by Ann Arbor Stage
        Ann Arbor Stage I Nodular Lymphocyte Predominant B-Cell Lymphoma
        Ann Arbor Stage II Nodular Lymphocyte Predominant B-Cell Lymphoma
        Ann Arbor Stage III Nodular Lymphocyte Predominant B-Cell Lymphoma
        Ann Arbor Stage IV Nodular Lymphocyte Predominant B-Cell Lymphoma
        Recurrent Nodular Lymphocyte Predominant B-Cell Lymphoma
        Refractory Nodular Lymphocyte Predominant B-Cell Lymphoma
        Non-Destructive Post-Transplant Lymphoproliferative Disorder
        Florid Follicular Hyperplasia Post-Transplant Lymphoproliferative Disorder
        Infectious Mononucleosis Post-Transplant Lymphoproliferative Disorder
        Plasmacytic Hyperplasia Post-Transplant Lymphoproliferative Disorder

Professional guidelines

PubMed

Waldenström macroglobulinemia: a review of pathogenesis, current treatment, and future prospects.

Ghafoor B, Masthan SS, Hameed M, Akhtar HH, Khalid A, Ghafoor S, Allah HM, Arshad MM, Iqbal I, Iftikhar A, Husnain M, Anwer F
Ann Hematol 2024 Jun;103(6):1859-1876. Epub 2023 Jul 6 doi: 10.1007/s00277-023-05345-9. PMID: 37414960

Follicular lymphoma: 2023 update on diagnosis and management.

Jacobsen E
Am J Hematol 2022 Dec;97(12):1638-1651. Epub 2022 Oct 18 doi: 10.1002/ajh.26737. PMID: 36255040

Follicular lymphoma: 2020 update on diagnosis and management.

Freedman A, Jacobsen E
Am J Hematol 2020 Mar;95(3):316-327. Epub 2019 Dec 22 doi: 10.1002/ajh.25696. PMID: 31814159

See all (37)

Recent clinical studies

Etiology

Follicular lymphoma: 2023 update on diagnosis and management.

Jacobsen E
Am J Hematol 2022 Dec;97(12):1638-1651. Epub 2022 Oct 18 doi: 10.1002/ajh.26737. PMID: 36255040

Follicular lymphoma: 2020 update on diagnosis and management.

Freedman A, Jacobsen E
Am J Hematol 2020 Mar;95(3):316-327. Epub 2019 Dec 22 doi: 10.1002/ajh.25696. PMID: 31814159

Follicular lymphoma: 2018 update on diagnosis and management.

Freedman A
Am J Hematol 2018 Feb;93(2):296-305. doi: 10.1002/ajh.24937. PMID: 29314206

Cryoglobulinemia Vasculitis.

Cacoub P, Comarmond C, Domont F, Savey L, Saadoun D
Am J Med 2015 Sep;128(9):950-5. Epub 2015 Mar 30 doi: 10.1016/j.amjmed.2015.02.017. PMID: 25837517

B cell lymphoproliferative disorders following hematopoietic stem cell transplantation: risk factors, treatment and outcome.

Gross TG, Steinbuch M, DeFor T, Shapiro RS, McGlave P, Ramsay NK, Wagner JE, Filipovich AH
Bone Marrow Transplant 1999 Feb;23(3):251-8. doi: 10.1038/sj.bmt.1701554. PMID: 10084256 Free PMC Article

See all (81)

Diagnosis

Follicular lymphoma: 2023 update on diagnosis and management.

Jacobsen E
Am J Hematol 2022 Dec;97(12):1638-1651. Epub 2022 Oct 18 doi: 10.1002/ajh.26737. PMID: 36255040

Follicular lymphoma: 2020 update on diagnosis and management.

Freedman A, Jacobsen E
Am J Hematol 2020 Mar;95(3):316-327. Epub 2019 Dec 22 doi: 10.1002/ajh.25696. PMID: 31814159

BRAF in the cross-hairs.

Geyer MB, Abdel-Wahab O, Tallman MS
Expert Rev Hematol 2019 Mar;12(3):183-193. Epub 2019 Feb 26 doi: 10.1080/17474086.2019.1583553. PMID: 30782032 Free PMC Article

Treatment recommendations from the Eighth International Workshop on Waldenström's Macroglobulinemia.

Leblond V, Kastritis E, Advani R, Ansell SM, Buske C, Castillo JJ, García-Sanz R, Gertz M, Kimby E, Kyriakou C, Merlini G, Minnema MC, Morel P, Morra E, Rummel M, Wechalekar A, Patterson CJ, Treon SP, Dimopoulos MA
Blood 2016 Sep 8;128(10):1321-8. Epub 2016 Jul 18 doi: 10.1182/blood-2016-04-711234. PMID: 27432877

Cryoglobulinemia Vasculitis.

Cacoub P, Comarmond C, Domont F, Savey L, Saadoun D
Am J Med 2015 Sep;128(9):950-5. Epub 2015 Mar 30 doi: 10.1016/j.amjmed.2015.02.017. PMID: 25837517

See all (167)

Therapy

Waldenström macroglobulinemia: a review of pathogenesis, current treatment, and future prospects.

Advances in Treatment of Waldenström Macroglobulinemia.

Durot E, Tomowiak C
Curr Oncol Rep 2023 Nov;25(11):1375-1386. Epub 2023 Oct 19 doi: 10.1007/s11912-023-01459-5. PMID: 37855849

Follicular lymphoma: 2023 update on diagnosis and management.

Jacobsen E
Am J Hematol 2022 Dec;97(12):1638-1651. Epub 2022 Oct 18 doi: 10.1002/ajh.26737. PMID: 36255040

Follicular lymphoma: 2020 update on diagnosis and management.

Freedman A, Jacobsen E
Am J Hematol 2020 Mar;95(3):316-327. Epub 2019 Dec 22 doi: 10.1002/ajh.25696. PMID: 31814159

BRAF in the cross-hairs.

Geyer MB, Abdel-Wahab O, Tallman MS
Expert Rev Hematol 2019 Mar;12(3):183-193. Epub 2019 Feb 26 doi: 10.1080/17474086.2019.1583553. PMID: 30782032 Free PMC Article

See all (121)

Prognosis

Follicular lymphoma: 2023 update on diagnosis and management.

Jacobsen E
Am J Hematol 2022 Dec;97(12):1638-1651. Epub 2022 Oct 18 doi: 10.1002/ajh.26737. PMID: 36255040

Advances in the Treatment of Hairy Cell Leukemia Variant.

Tran J, Gaulin C, Tallman MS
Curr Treat Options Oncol 2022 Jan;23(1):99-116. Epub 2022 Feb 18 doi: 10.1007/s11864-021-00927-z. PMID: 35178674

Follicular lymphoma: 2020 update on diagnosis and management.

Freedman A, Jacobsen E
Am J Hematol 2020 Mar;95(3):316-327. Epub 2019 Dec 22 doi: 10.1002/ajh.25696. PMID: 31814159

BRAF in the cross-hairs.

Geyer MB, Abdel-Wahab O, Tallman MS
Expert Rev Hematol 2019 Mar;12(3):183-193. Epub 2019 Feb 26 doi: 10.1080/17474086.2019.1583553. PMID: 30782032 Free PMC Article

Cryoglobulinemia Vasculitis.

Cacoub P, Comarmond C, Domont F, Savey L, Saadoun D
Am J Med 2015 Sep;128(9):950-5. Epub 2015 Mar 30 doi: 10.1016/j.amjmed.2015.02.017. PMID: 25837517

See all (99)

Clinical prediction guides

Follicular lymphoma: 2023 update on diagnosis and management.

Jacobsen E
Am J Hematol 2022 Dec;97(12):1638-1651. Epub 2022 Oct 18 doi: 10.1002/ajh.26737. PMID: 36255040

Follicular lymphoma: 2020 update on diagnosis and management.

Freedman A, Jacobsen E
Am J Hematol 2020 Mar;95(3):316-327. Epub 2019 Dec 22 doi: 10.1002/ajh.25696. PMID: 31814159

Follicular lymphoma: 2018 update on diagnosis and management.

Freedman A
Am J Hematol 2018 Feb;93(2):296-305. doi: 10.1002/ajh.24937. PMID: 29314206

Follicular lymphoma: 2014 update on diagnosis and management.

Freedman A
Am J Hematol 2014 Apr;89(4):429-36. doi: 10.1002/ajh.23674. PMID: 24687887

B cell lymphoproliferative disorders following hematopoietic stem cell transplantation: risk factors, treatment and outcome.

Gross TG, Steinbuch M, DeFor T, Shapiro RS, McGlave P, Ramsay NK, Wagner JE, Filipovich AH
Bone Marrow Transplant 1999 Feb;23(3):251-8. doi: 10.1038/sj.bmt.1701554. PMID: 10084256 Free PMC Article

See all (71)

Recent systematic reviews

Impact of direct acting antivirals on hepatitis C virus-related cryoglobulinemic syndrome.

Zignego AL, Marri S, Gragnani L
Minerva Gastroenterol (Torino) 2021 Sep;67(3):218-226. Epub 2021 Apr 1 doi: 10.23736/S2724-5985.21.02848-8. PMID: 33793154

Response to the Therapy in Hairy Cell Leukemia: Systematic Review and Meta-Analysis.

Andrasiak I, Rybka J, Wrobel T
Clin Lymphoma Myeloma Leuk 2018 Jun;18(6):392-399.e3. Epub 2018 Mar 31 doi: 10.1016/j.clml.2018.03.011. PMID: 29685423

Alkylating agents for Waldenstrom's macroglobulinaemia.

Yang K, Tan J, Wu T
Cochrane Database Syst Rev 2009 Jan 21;(1):CD006719. doi: 10.1002/14651858.CD006719.pub3. PMID: 19160296

See all (3)

MedGen

National Center for Biotechnology Information

Send to:

B-Cell Lymphoproliferative Disorder

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity