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Childhood leukemia

MedGen UID:: 234132
•Concept ID:: C1332977
•: Neoplastic Process

Synonyms:	childhood leukaemia (disease); Childhood Leukemia; childhood leukemia; childhood leukemia (disease); leukaemia (disease) of childhood; leukemia (disease) of childhood; paediatric leukaemia (disease); pediatric leukemia (disease)

Monarch Initiative:	MONDO:0004355

Definition

An acute or chronic leukemia that occurs during childhood. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVChildhood leukemia

Pathological process
- Disease
  - Neoplasm
    - Neoplasm by Special Category
      - Childhood neoplasm
        Childhood malignant neoplasm
        Childhood leukemia
        Childhood acute lymphoblastic leukemia
        Adult L1 Acute Lymphoblastic Leukemia
        B-cell childhood acute lymphoblastic leukemia
        Childhood B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1
        Childhood L1 Acute Lymphoblastic Leukemia
        Infant Acute Lymphoblastic Leukemia
        Infant Acute Lymphoblastic Leukemia with KMT2A Rearrangement
        Infant Acute Lymphoblastic Leukemia without KMT2A Rearrangement
        Infant T Acute Lymphoblastic Leukemia
        Recurrent Childhood Acute Lymphoblastic Leukemia
        Recurrent Childhood T Acute Lymphoblastic Leukemia
        Refractory Childhood Acute Lymphoblastic Leukemia
        T-cell childhood acute lymphocytic leukemia
        Childhood acute myeloid leukemia
        Acute Megakaryoblastic Leukemia with CBFA2T3-GLIS2
        Acute Myeloid Leukemia with RAM Immunophenotype
        Acute Myeloid Leukemia with t(6;11)(q27;q23.3); MLLT4-KMT2A
        Acute Myeloid Leukemia with t(7;12)(q36;p13); HLXB9-ETV6
        Childhood Acute Myeloid Leukemia Not Otherwise Specified
        Childhood Acute Basophilic Leukemia
        Childhood Acute Erythroid Leukemia
        Childhood acute megakaryoblastic leukemia
        Childhood Acute Monoblastic and Monocytic Leukemia
        Childhood Acute Myeloid Leukemia with Maturation
        Childhood Acute Myeloid Leukemia with Minimal Differentiation
        Childhood Acute Myeloid Leukemia without Maturation
        Childhood Acute Myelomonocytic Leukemia
        Childhood Acute Myeloid Leukemia with Abnormalities of Chromosome 7
        Childhood Acute Myeloid Leukemia with Abnormalities of Chromosome 5q
        Childhood Acute Myeloid Leukemia with NUP98 Rearrangement
        Childhood Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARA
        Recurrent Childhood Acute Myeloid Leukemia
        Childhood Burkitt Leukemia
        Childhood Chronic Myeloid Leukemia, BCR-ABL1 Positive
        Infant Leukemia
        Infant Acute Biphenotypic Leukemia
        Infant Acute Undifferentiated Leukemia
        Neonatal leukemia

Professional guidelines

PubMed

Foreword: Childhood Leukemia and Primary Prevention.

Etzel RA
Curr Probl Pediatr Adolesc Health Care 2016 Oct;46(10):315-316. doi: 10.1016/j.cppeds.2016.08.003. PMID: 27968953

Bone morbidity in childhood leukemia: epidemiology, mechanisms, diagnosis, and treatment.

Mostoufi-Moab S, Halton J
Curr Osteoporos Rep 2014 Sep;12(3):300-12. doi: 10.1007/s11914-014-0222-3. PMID: 24986711 Free PMC Article

Treatment of childhood leukemia.

Silverman LB, Weinstein HJ
Curr Opin Oncol 1997 Jan;9(1):26-33. doi: 10.1097/00001622-199701000-00005. PMID: 9090491

See all (143)

Recent clinical studies

Etiology

Risk Factors for Childhood Leukemia: Radiation and Beyond.

Schmidt JA, Hornhardt S, Erdmann F, Sánchez-García I, Fischer U, Schüz J, Ziegelberger G
Front Public Health 2021;9:805757. Epub 2021 Dec 24 doi: 10.3389/fpubh.2021.805757. PMID: 35004601 Free PMC Article

Exposure to pesticides and childhood leukemia risk: A systematic review and meta-analysis.

Karalexi MA, Tagkas CF, Markozannes G, Tseretopoulou X, Hernández AF, Schüz J, Halldorsson TI, Psaltopoulou T, Petridou ET, Tzoulaki I, Ntzani EE
Environ Pollut 2021 Sep 15;285:117376. Epub 2021 May 18 doi: 10.1016/j.envpol.2021.117376. PMID: 34380208

Foreword: Childhood Leukemia and Primary Prevention.

Etzel RA
Curr Probl Pediatr Adolesc Health Care 2016 Oct;46(10):315-316. doi: 10.1016/j.cppeds.2016.08.003. PMID: 27968953

Infectious origins of childhood leukemia.

Swaminathan S, Müschen M
Oncotarget 2015 Jul 10;6(19):16798-9. doi: 10.18632/oncotarget.4630. PMID: 26196452 Free PMC Article

The childhood leukemias.

Colby-Graham MF, Chordas C
J Pediatr Nurs 2003 Apr;18(2):87-95. doi: 10.1053/jpdn.2003.9. PMID: 12720205

See all (1299)

Diagnosis

Genes and childhood leukemia.

Kęsy J, Januszkiewicz-Lewandowska D
Postepy Hig Med Dosw (Online) 2015 Mar 5;69:302-8. doi: 10.5604/17322693.1142719. PMID: 25748621

Leukemia and lymphoma.

Guillerman RP, Voss SD, Parker BR
Radiol Clin North Am 2011 Jul;49(4):767-97, vii. Epub 2011 Jun 25 doi: 10.1016/j.rcl.2011.05.004. PMID: 21807173

The childhood leukemias.

Colby-Graham MF, Chordas C
J Pediatr Nurs 2003 Apr;18(2):87-95. doi: 10.1053/jpdn.2003.9. PMID: 12720205

Leukemic arthritis.

Evans TI, Nercessian BM, Sanders KM
Semin Arthritis Rheum 1994 Aug;24(1):48-56. doi: 10.1016/0049-0172(94)90099-x. PMID: 7985037

Acute lymphoblastic leukemia.

Miller DR
Pediatr Clin North Am 1980 May;27(2):269-91. doi: 10.1016/s0031-3955(16)33851-2. PMID: 6992074

See all (839)

Therapy

Foreword: Childhood Leukemia and Primary Prevention.

Etzel RA
Curr Probl Pediatr Adolesc Health Care 2016 Oct;46(10):315-316. doi: 10.1016/j.cppeds.2016.08.003. PMID: 27968953

Late effects of childhood leukemia therapy.

Fulbright JM, Raman S, McClellan WS, August KJ
Curr Hematol Malig Rep 2011 Sep;6(3):195-205. doi: 10.1007/s11899-011-0094-x. PMID: 21695425

A history of cancer chemotherapy.

DeVita VT Jr, Chu E
Cancer Res 2008 Nov 1;68(21):8643-53. doi: 10.1158/0008-5472.CAN-07-6611. PMID: 18974103

The childhood leukemias.

Colby-Graham MF, Chordas C
J Pediatr Nurs 2003 Apr;18(2):87-95. doi: 10.1053/jpdn.2003.9. PMID: 12720205

Methotrexate and childhood leukemia.

Jonsson OG, Kamen BA
Cancer Invest 1991;9(1):53-60. doi: 10.3109/07357909109032800. PMID: 2012997

See all (955)

Prognosis

Genes and childhood leukemia.

Kęsy J, Januszkiewicz-Lewandowska D
Postepy Hig Med Dosw (Online) 2015 Mar 5;69:302-8. doi: 10.5604/17322693.1142719. PMID: 25748621

Childhood leukemia.

Hutter JJ
Pediatr Rev 2010 Jun;31(6):234-41. doi: 10.1542/pir.31-6-234. PMID: 20516235

Breastfeeding and maternal and infant health outcomes in developed countries.

Ip S, Chung M, Raman G, Chew P, Magula N, DeVine D, Trikalinos T, Lau J
Evid Rep Technol Assess (Full Rep) 2007 Apr;(153):1-186. PMID: 17764214 Free PMC Article

The childhood leukemias.

Colby-Graham MF, Chordas C
J Pediatr Nurs 2003 Apr;18(2):87-95. doi: 10.1053/jpdn.2003.9. PMID: 12720205

Leukemic arthritis.

Evans TI, Nercessian BM, Sanders KM
Semin Arthritis Rheum 1994 Aug;24(1):48-56. doi: 10.1016/0049-0172(94)90099-x. PMID: 7985037

See all (694)

Clinical prediction guides

Exposure to pesticides and childhood leukemia risk: A systematic review and meta-analysis.

Single-cell analysis of childhood leukemia reveals a link between developmental states and ribosomal protein expression as a source of intra-individual heterogeneity.

Caron M, St-Onge P, Sontag T, Wang YC, Richer C, Ragoussis I, Sinnett D, Bourque G
Sci Rep 2020 May 15;10(1):8079. doi: 10.1038/s41598-020-64929-x. PMID: 32415257 Free PMC Article

Residential mobility and childhood leukemia.

Amoon AT, Oksuzyan S, Crespi CM, Arah OA, Cockburn M, Vergara X, Kheifets L
Environ Res 2018 Jul;164:459-466. Epub 2018 Mar 23 doi: 10.1016/j.envres.2018.03.016. PMID: 29574256 Free PMC Article

Infectious Agents in Childhood Leukemia.

Arellano-Galindo J, Barrera AP, Jiménez-Hernández E, Zavala-Vega S, Campos-Valdéz G, Xicohtencatl-Cortes J, Ochoa SA, Cruz-Córdova A, Crisóstomo-Vázquez MDP, Fernández-Macías JC, Mejía-Aranguré JM
Arch Med Res 2017 May;48(4):305-313. doi: 10.1016/j.arcmed.2017.09.001. PMID: 29157671

Bone morbidity in childhood leukemia: epidemiology, mechanisms, diagnosis, and treatment.

Mostoufi-Moab S, Halton J
Curr Osteoporos Rep 2014 Sep;12(3):300-12. doi: 10.1007/s11914-014-0222-3. PMID: 24986711 Free PMC Article

See all (606)