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Series GSE147002 Query DataSets for GSE147002
Status Public on Jul 02, 2020
Title DNA methylation profiles from a mouse model of Huntington's disease
Platform organisms Homo sapiens; Mus musculus; Rattus norvegicus
Sample organism Mus musculus
Experiment type Methylation profiling by genome tiling array
Summary An Infinium microarray platform (HorvathMammalMethylChip40) was used to generate DNA methylation data from mouse tissues of a heterozygous Huntingtin expansion knock-in (Q175) and wildtype (WT) controls.
Mouse tissues: blood, liver, brain cortex, brain cerebellum, and striatum.
 
Overall design Mouse strain: C57B/l6J. Two genotypes: Q175 (Htt knockin) and WT control. Mice were sacrificed at age 6 months. Roughly sex balanced (half females).
Each sample characteristics value represents:
characteristics: Basename = the usual identifier of the methylation array comprised of the SENTRIX ID (i.e. chip identifier) and position (row and column).
characteristics: Age = Age at the time of sacrifice. 6 months old mice.
characteristics: Sex = F for female mice and M for male mice.
characteristics: Genotype = Huntington disease status genotype status: Q175 is the heterozygous knock-in model of Huntington disease. WT denotes wild type controls.
 
Contributor(s) Horvath S, Yang XW
Citation(s) 32913184, 37563227, 38848365
Submission date Mar 15, 2020
Last update date Jun 26, 2024
Contact name Steve Horvath
E-mail(s) shorvath@altoslabs.com
Organization name University of California, Los Angeles
Department Human Genetics
Lab Horvath
Street address 695 Charles E. Young Drive South, Box 708822
City Los Angeles
State/province CA
ZIP/Postal code 90095-7088
Country USA
 
Platforms (1)
GPL28271 Illumina HorvathMammalianMethylChip40 BeadChip
Samples (72)
GSM4411953 genomic DNA methylation from mouse3510-bloodWT
GSM4411954 genomic DNA methylation from mouse3640-bloodQ175
GSM4411955 genomic DNA methylation from mouse3531-bloodQ175
This SubSeries is part of SuperSeries:
GSE147004 DNA Methylation Study of Huntington's Disease and Motor Progression in Three Species
Relations
BioProject PRJNA612723

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE147002_RAW.tar 54.1 Mb (http)(custom) TAR (of IDAT)
Processed data included within Sample table
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