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Series GSE147003 Query DataSets for GSE147003
Status Public on Jul 02, 2020
Title DNA methylation profiles from a transgenic sheep model of Huntington's disease
Platform organisms Homo sapiens; Mus musculus; Rattus norvegicus
Sample organism Ovis aries
Experiment type Methylation profiling by genome tiling array
Summary An Infinium microarray platform (HorvathMammalMethylChip40) was used to generate DNA methylation data from n=168 blood samples of a transgenic sheep model of Huntington's disease.
84 transgenic sheep and age matched control sheep.
 
Overall design Two genotypes (transgenic) and control. Roughly sex balanced (half females).
Each sample characteristics value represents:
characteristics: Basename = usual identifier of the methylation array comprised of the SENTRIX ID (i.e. chip identifier) and position (row and column).
characteristics: Age (Years) = Age at the time of blood draw in units of years.
characteristics: Sex = female denotes female sheep.
characteristics: Genotype = Transgenic denotes Huntington disease status,
This ovine transgenic Huntington's disease model is described in the PMID: 20154343 article:
 
Contributor(s) Horvath S, Snell RG
Citation(s) 32913184, 37563227, 38848365
Submission date Mar 15, 2020
Last update date Jun 26, 2024
Contact name Steve Horvath
E-mail(s) shorvath@altoslabs.com
Organization name University of California, Los Angeles
Department Human Genetics
Lab Horvath
Street address 695 Charles E. Young Drive South, Box 708822
City Los Angeles
State/province CA
ZIP/Postal code 90095-7088
Country USA
 
Platforms (1)
GPL28271 Illumina HorvathMammalianMethylChip40 BeadChip
Samples (168)
GSM4412025 genomic DNA methylation from sheepBloodHD801Control
GSM4412026 genomic DNA methylation from sheepBloodHD807Transgenic
GSM4412027 genomic DNA methylation from sheepBloodHD897Control
This SubSeries is part of SuperSeries:
GSE147004 DNA Methylation Study of Huntington's Disease and Motor Progression in Three Species
Relations
BioProject PRJNA612722

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE147003_RAW.tar 125.6 Mb (http)(custom) TAR (of IDAT)
Processed data included within Sample table
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